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- Contact Us – Peptide Quote
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- Isotope Chemistry
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Diazoketone chemistry, an area where Almac has exclusive expertise, is a powerful synthetic tool offering routes to novel building blocks, scaffolds, and screening compounds and a wide range of homochiral synthetic intermediates. Frequently diazo chemistry provides direct routes to structures otherwise inaccessible or requiring multistep alternatives.
We provide a service in synthesis design, route optimisation, process development and high-value, low volume custom synthesis utilising diazo intermediates.
Diazocarbonyls, especially diazoketones and diazoesters are versatile intermediates for a vast range of chemical transformations which are characterised by: high yields; mild reaction conditions; high chemoselectivity and regiospecificity.
Diazoketones provide easy access to key intermediates whatever the nature of R.
- Diazoketones Derived from Amino Acids
- β-aminoacid Derivatives via Arndt-Eistert Homologation
- Halohydrins and Epoxides from α-halogenated Ketones
- α-N-protected Aminoglyoxals via Oxidation
- Cyclopropane-Substituted Amino Acids via Cyclopropanation with Ethyl Diazoactetate