Almac

Diazoketone chemistry, an area where Almac has exclusive expertise, is a powerful synthetic tool offering routes to novel building blocks, scaffolds, and screening compounds and a wide range of homochiral synthetic intermediates. Frequently diazo chemistry provides direct routes to structures otherwise inaccessible or requiring multistep alternatives.

We provide a service in synthesis design, route optimisation, process development and high-value, low volume custom synthesis utilising diazo intermediates.

Diazocarbonyls, especially diazoketones and diazoesters are versatile intermediates for a vast range of chemical transformations which are characterised by: high yields; mild reaction conditions; high chemoselectivity and regiospecificity.

Diazoketones provide easy access to key intermediates whatever the nature of R.

• Diazoketones Derived from Amino Acids
• β-aminoacid Derivatives via Arndt-Eistert Homologation
• Halohydrins and Epoxides from α-halogenated Ketones
• α-N-protected Aminoglyoxals via Oxidation
• Cyclopropane-Substituted Amino Acids via Cyclopropanation with Ethyl Diazoactetate

• Downloads

• The numerous ways for α-functionalisation of a ketone via a single diazocarbonyl intermediate.