Almac

Radio Isotopes

¹⁴C labelling is a highly flexible cost effective solution for radiolabelled products particularly for use in ADME studies. Additional benefits are that high specific activities can be achieved, with avoidance of the lability challenges encountered with ³H labelling. Relative safety is assured through low energy beta decay and the long halflife of ¹⁴C results in insignificant loss of label due to decay.

Stable Isotopes

²H, ¹³C, and ¹⁵N stable labels are available. We will assess potential lability, stability and metabolism issues and recommend the best isotope and label position.

There are no radiation safety issues and isotopic enrichments greater than 98% are typically available. High sensitivity of detection is assured through state-of-the-art mass spectrometry, while multiple labelling can deliver complete mass resolution from an unlabelled analogue.

And By The Way…

Our additional label capabilities include:

• Peptide-Dye Conjugates
• Alexafluor™
• BODIPY™