Almac

Biocatalysts are essential tools in chemical synthesis, particularly in the syntheses of pharmaceutical targets. As highly selective catalysts, they offer a direct and simple way to synthesise complex chiral compounds.

Almac’s selectAZyme^TM platform offers a range of enzymes for carrying out a wide variety of chemical reactions. In addition, we provide the expertise to guide your synthesis from conception to scale-up. We also supply a variety of unique chiral building blocks and scaffolds to our customers.

We Offer:

• FTE or FFS contracts.
• Screening of our biocatalyst toolbox with customer substrates comprising biocatalyst selection and route demonstration.
• Biocatalytic route invention and process development.
• Enzyme supply on a £/Kg basis.
• Enzyme evolution
• Tech transfer and ongoing support through all the manufacturing steps including the training of personnel if required.
• Supply of chiral intermediates.
• Microbial screening and molecular biology for the development of novel biocatalysts.
• Fermentation development and scale-up.
• Metabolite synthesis

Almac Will Support You With:

• Searching for new enzyme activities (specialist cultivation and screening of wild type organisms).
• Isolation, purification and characterisation of enzymes from diverse genera.
• Cloning, recombinant overexpression and fermentation using our in-house expression systems.