- API Development & Manufacture
- API Toxicology & GMP Supply
- Peptide & Protein Technology
- Custom Peptides
- GMP Peptide API
- Immunograde Peptides
- Modified Histones
- Protein Conjugation Technology
- Facilities and Equipment
- Contact Us – Peptide Quote
- API Radiolabelling
- Solid State Characterisation
- Solid State Services
- Drug Product
- Isotope Chemistry
- Pre-Clinical Safety Assessment
- Biocatalysis / selectAZyme™
- FLEXYTE™ Fluorescence Lifetime Assays
- Animal Free Chemokines
Often, preclinical formulations improve the in vitro solubility of poorly soluble APIs, but do little to improve their bioavailability. Almac has developed and implemented formufastTM screens, a smart and fast approach of developing rational formulations with improved solubility and bioavailability characteristics. This service perfectly fits the needs of drug discovery and preformulation groups where the availability of material is limited.
formufastTM allows rapid screening of small quantities of API against a range of formulation vehicles. The solubility of the molecule is screened in a tailored matrix of commonly used GRAS excipients and physiologically relevant buffers and mixtures. The API solubilising capacity for each of the excipients in the intended drug delivery environment is quantified and suitable formulations developed. Using formufastTM screens, suitable solubility enhancing excipients can be identified within 72 hours using as little as 25mg of API.
Advantages of formufastTM screening:
- Saves material and time
- Rank ordering of excipients based on solubilising capacity in the relevant media
- Reduces the need for repetition of costly PK and Tox studies due to formulation failures.
formufastTM can be used to design and prepare oral, parenteral and solid dispersion formulations.
For more information on the specific services offered, please contact us.