• Introduction
  • Why Almac?
  • People
  • Facilities
• Biomarker Discovery and Validation
  • Companion Diagnostics
  • Pharmacodynamic Biomarkers
  • Prognostic tests
  • Drug Repositioning
  • Consultancy
• Bioinformatics Solutions
  • Gene Selection
  • Signature generation
  • Functional analysis
• Genomic services
  • Gene Expression and SNP analysis
  • qPCR and cell line modelling
  • Bioinformatics
• Proprietary Discovery Arrays
  • Unique Content
  • Work with FFPE and fresh frozen tissue
  • Discover Targets, signatures and answers
• Resources
  • Technical Documentation
  • Posters and presentations
  • Publications

Publications

• Developing mRNA-based biomarkers from formalin-fixed paraffin-embedded tissue. Austin Tanney, Richard D Kennedy
  Personalized Medicine, Mar 2010, Vol. 7, No. 2, Pages 205-211
  
  
• Genomic markers for decision making: what is preventing us from using markers? Coyle VM, Johnston PG. Nat Rev Clin Oncol. 2010 Feb;7(2):90-7. Epub 2009 Dec 15
  
  
• Identification of differentially expressed sense and antisense transcript pairs in breast epithelial tissues. Grigoriadis A, Oliver GR, Tanney A, Kendrick H, Smalley MJ, Jat P, Neville AM. BMC Genomics. 2009 Jul 17;10:324.
  

• Tissue Biomarker Development in a Multicentre Trial Context: a Feasibility Study on the PETACC3 Stage II and III Colon Cancer Adjuvant Treatment Trial. Bosman FT, Yan P, Tejpar S, Fiocca R, Van Cutsem E, Kennedy RD, Dietrich D, Roth A. Clin Cancer Res. 2009 Sep 1;15(17):5528-33

  
  
• RNA expression analysis from formalin fixed paraffin embedded tissues. Farragher SM, Tanney A, Kennedy RD, Paul Harkin D. Histochem Cell Biol. 2008  vol. 130, issue 3, pp 435-445
  
  The original publication is available at springerlink.com
• Molecular basis for estrogen receptor alpha deficiency in BRCA1-linked breast cancer. Hosey AM, Gorski JJ, Murray MM, Quinn JE, Chung WY, Stewart GE, James CR, Farragher SM, Mulligan JM, Scott AN, Dervan PA, Johnston PG, Couch FJ, Daly PA, Kay E, McCann A, Mullan PB, Harkin DP.  J Natl Cancer Inst. 2007 Nov 21;99(22):1683-94
  
  The original publication is available at oxforjournals.org
• Affymetrix Microarray Bulletin: Interview with Dr. Lisa Baumbach on her research incorporating the use of the Breast cancer DSA^®  research tool.
  
  
• Generation of a non-small cell lung cancer transcriptome microarray. Tanney A, Oliver GR, Farztdinov V, Kennedy RD, Mulligan JM, Fulton CE, Farragher SM, Field JK, Johnston PG, Harkin DP, Proutski V, Mulligan KA. BMC Med Genomics. 2008 1:20.