Dosage Forms & Scale of Manufacture, Modified release, controlled release, sustained release, extended release, bilayer tablets, tab-in-tab tablets, MR tablets

Dosage Forms & Scale of Manufacture

Our formulation team has wide and varied experience in developing both immediate and modified release dosage forms for proof-of-concept studies through to late stage clinical trials and commercialisation.

We can offer expertise in the development of the following dosage forms:

  • Immediate and Modified Release Capsules
  • Immediate and Modified Release Tablets
  • Fixed Dose Combinations
  • Powder / Granule Filled Bottles and Sachets

Modified Release

When developing modified release dosage forms we typically use one of the following approaches to achieve the desired release profile:

  • Matrix Systems:
    • Insoluble / Swellable
    • Eroding Matrix
    • Hydrogels
    • Polymeric Matrix
    • Wax Matrix
  • Coating Systems:
    • Coated Pellets
    • Coated Tablets
    • pH Sensitive Coatings
    • Film Coating
    • Wurster Coating

Manufacturing Technologies & Scale

For the different stages of manufacture we can offer the following technologies at scales ranging from hundreds of grams for initial formulation development work to hundreds of kilograms in some cases for phase III/IV and registration batch requirements:

  • Dry Powder Blending
  • Roller Compaction
  • High Shear Granulation (Aqueous and Solvent capabilities)
  • Fluid Bed Granulation (Aqueous and Solvent capabilities)
  • Spray Drying
  • Encapsulation – Single and Combination Doses of Powders, Pellets & Tablets
  • Tabletting – Single Layer, Bi-Layer and Compression Coating / Tab-in-Tab Formats
  • Pan Coating (Aqueous and Solvent capabilities)
  • Fluid Bed Coating / Wurster coating (Aqueous and Solvent capabilities)
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