• Introduction
• API Development and Manufacture
  • Medicinal Chemistry Support
  • First in Man (Rapidd™)
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• Solid State Services
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• Analytical
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  • Facilities and Instrumentation
• Peptides and Proteins
  • GMP Peptide API
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  • Site Specific PEGylation
    • Ligation Technology
    • Application to PEGylation
  • Facilities and Equipment
  • Quote
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• Biocatalysis
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  • Enzyme Kit Quotation Request

Application to PEGylation

The protein of interest (POI) is expressed as an intein fusion, treated with hydrazine to form a hydrazide and reacted with pyruvol PEG to form a C-termainl PEGylated protein.

• Example 1: Interferon alpha 2 b
• Example 2: Interferon beta 1 b