Characterisation
Methods and capabilities to characterise drug substance & product:
- X-ray Powder Diffraction (XRPD): determination of crystal form
- Variable-Temperature XRPD: used to investigate solid state transformations, dehydration/desolvation and recrystallisations.
- Thermal Analysis:
- DSC: Detects thermal transitions
- Hyper DSC: applied to study of metastable polymorphs.
- TGA/DTA: to provide information on volatile content - a secondary technique (TG-IR) identifies volatiles
- Hot Stage Microscopy with DSC: for the observation and identification of phase changes such as melt, recrystallisation, desolvation or dehydration.
- FTIR: physical characterisation of pharmaceutical solids
- Microscopy / Malvern Particle Sizer: determination of particle size
- NMR: chemical identification and structure elucidation
- Solubility and Crystallisation Station: determination of solubility and metastable zone width of compounds
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