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Diazo Chemistry

Diazoketone chemistry, an area where Almac Sciences has exclusive expertise, is a powerful synthetic tool offering routes to novel building blocks, scaffolds, and screening compounds and a wide range of homochiral synthetic intermediates. Frequently diazo chemistry provides direct routes to structures otherwise inaccessible or requiring multistep alternatives.

We provide a service in synthesis design, route optimisation, process development and high-value, low volume custom synthesis utilising diazo intermediates.

Diazocarbonyls, especially diazoketones and diazoesters are versatile intermediates for a vast range of chemical transformations which are characterised by: high yields; mild reaction conditions; high chemoselectivity and regiospecificity.

Diazoketones provide easy access to key intermediates whatever the nature of R.

diazoketones derived from amino acids
β-aminoacid derivatives via Arndt-Eistert homologation
halohydrins and epoxides from α-halogenated ketones
α-N-protected aminoglyoxals via oxidation
cyclopropane-substituted amino acids via cyclopropanation with ethyl diazoactetate

Click here to see the numerous ways for α-functionalisation of a ketone via a single diazocarbonyl intermediate.