Like many other companies and institutions around the world, we are experiencing interference with some of our systems within the TNT network.
We are implementing remediation steps as quickly as possible. We have implemented operational contingencies to continue to complete collections from customers with scheduled stops. For customers who do not have a regular stop, collection should be arranged via our customer service centers.
Customers may experience delays in the transit of shipments, particularly inter-continental or non-EU European delivery, as we work to remediate our systems. Additionally, if customers do not have the facility for self-labeling, they may also experience delays.
We are not able to collect shipments of dangerous goods at this time.
We regret any inconvenience to our customers.
Finding the most stable form of the API
Polymorph screening is designed to find the most stable form of the API and to define the form for clinical development and GMP manufacture. During the screening, the tendency to form polymorphs, solvates, and hydrates in typical processing solvents and under typical process conditions (e.g., drying, milling and compaction) is thoroughly investigated.
Our screening services are directed by highly trained chemists and analysts performing a scientific investigation tailored to your API properties, development phase and budget, rather than generic protocols using robotics. A tailored, manual/semi- automated investigation conducted by experienced specialists is widely regarded as the preferred approach and has been found to perform as well as, or better, than high throughput screening, while using fewer experiments1.
1 A.J.Alvarez, A.Singh, A.S.Myerson, “Polymorph Screening: Comparing a Semi-Automated Approach with a High Throughput Method”, Crystal Growth and Design, 2009, 9, 4181-4188