{"id":53,"date":"2020-02-03T13:38:18","date_gmt":"2020-02-03T13:38:18","guid":{"rendered":"https:\/\/www.almacgroup.com\/analytical-solid-state\/?page_id=53"},"modified":"2025-06-12T10:33:15","modified_gmt":"2025-06-12T09:33:15","slug":"solid-state-services","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/analytical-solid-state\/solid-state-services\/","title":{"rendered":"Solid State Services"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\" id=\"h-through-the-creation-of-synergy-between-solid-state-chemistry-and-formulation-development-our-experienced-scientists-have-the-ability-to-add-great-value-to-your-pre-clinical-project-while-decreasing-timelines\">Through the creation of synergy between solid state chemistry and formulation development, our experienced scientists have the ability to add great value to your pre-clinical project, while decreasing timelines.<\/h3>\n\n\n\n<div class=\"c-table__bg lazyload\" style=\"background-image:inherit\" data-bg-image=\"url(..\/wp-content\/uploads\/sites\/6\/2020\/03\/banner-api-chemical-1.jpg;)\"><table class=\"\"><thead><tr><td>&nbsp;<\/td><td>Characterisation<\/td><td>Physical form<\/td><td>Formulation<\/td><td>Stability<\/td><\/tr><\/thead><tbody><tr><td>Small molecules<\/td><td>Crystallinity<br>\nHygroscopicity<br>\nParticle size, shape surface area<br>\nMoisture \/ solvent content<\/td><td>Polymorph screening<br>\nSalt \/ cocrystal screening<br>\nAmorphous dispersion screening<br>\nStable form determination<\/td><td>pH-solubility profile, pKa and logP<br>\nPermeability (Caco-2)<br>\nBCS classification<br>\nSolubility in pharmaceutical solvents &amp; bio-relevant buffers<br>\nformufast\u2122 screening<\/td><td rowspan=\"2\">Solid state stability<br>\n(heat, humidity, light); Solution stability<br>\n(pH, oxidation, heat, light)<\/td><\/tr><tr><td>Peptides<\/td><td>LC-MS<br>\nAbsorption and fluorescence spectroscopy<br>\nCircular dichroism<br>\nNMR<\/td><td>Enabling salt screen<\/td><td>Solubility in pharmaceutical solvents &amp; bio-relevant buffers<br>\nPrecipitation assessment<\/td><\/tr><\/tbody><\/table><\/div>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-service-overview\">Service Overview<\/h3>\n\n\n\n<p>Our Physical Sciences group has a considerable breadth of expertise in form screening and selection, so they can skilfully guide you to make the right decisions at the right time. Read more on our form screening and selection services:<\/p>\n\n\n\n<p><strong>Enabling Salt Screen<\/strong><\/p>\n\n\n\n<p>If your drug candidate is at risk of failure due to poor oral bioavailability, handling issues or instability, or simply you want to develop a new dosage form, a salt (or cocrystal) form has the potential to dramatically improve the drug properties. An enabling salt screen has a quick turnaround and can be performed on less than 100mg. Almac has a proven track record in getting troublesome discovery candidates into the clinical phase using this method.<\/p>\n\n\n\n<p><strong>Polymorph Screening<\/strong><\/p>\n\n\n\n<p>Polymorph screening is designed to reduce the risks of drug development by finding the most stable form of the API and to define the form for clinical development and GMP manufacture. Our screening services are directed by highly trained chemists and analysts performing a scientific investigation tailored to your API properties, development phase and budget, rather than generic protocols using robotics.<\/p>\n\n\n\n<p><strong>Salt and Cocrystal Screening<\/strong><\/p>\n\n\n\n<p>The selection of an appropriate salt provides an opportunity to modify the API\u2019s physicochemical properties and resultant biological characteristics. However, the salt form selected will influence a range of other properties. It should also be noted that screening for developable salt forms could strengthen the intellectual property of the API. A salt or cocrystal can also enable you to go over the next hurdle in the pharmaceutical drug development process, whether this is to move onto the initial toxicity studies or to go into clinical drug development.<\/p>\n\n\n\n<p><strong>Amorphous Solids<\/strong><\/p>\n\n\n\n<p>Amorphous drug substances can exhibit enhanced solubility over a crystalline form. However, the amorphous solid may be unstable to recrystallisation during the shelf life of a product unless it is stabilised as an amorphous solid dispersion. We can rapidly identify the most suitable polymers at the correct concentration for early drug formulation development. Prototypes are generated by solvent casting, co-melting, freeze drying or spray drying, fully characterised and their stability assessed. The scope will be tailored to your needs, development phase and budget.<\/p>\n\n\n\n<p><a class=\"c-btn\" href=\"\/analytical-solid-state\/contact-us\/\">Contact Us<\/a><\/p>\n\n\n\t<article class=\"o-grid o-grid--full\">\n\n\t\t<div class=\"o-grid__item u-width-full u-m-t6 u-m-t4@m u-m-b4\">\n\t\t\t<h2 class=\"u-normal u-a-center\">Related Resources<\/h2>\n\t\t<\/div>\n\n\t\t<div class=\"u-flex u-flex-justify-center u-flex-wrap u-width-full c-news-panels__slider js-news-panels\">\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/leaders-in-pharma-podcast-featuring-jonathan-loughrey-and-terry-ernest\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2025\/06\/almac-physical-sciences-030-scaled.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Podcast<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Leaders in Pharma Podcast Featuring Jonathan Loughrey and Terry Ernest<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/api-chemical-development\/ensuring-consistency-in-polymorphic-drug-substances-and-products\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2020\/04\/Ensuring-Consistency-in-Polymorphic-Drug-Substances-and-Products-300x250-1.png&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">White paper<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Ensuring Consistency in Polymorphic Drug Substances and Products<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/solid-state-services-brochure\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2020\/04\/Solid-State-Services-Brochure-300x171-1.png&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Solid State Services<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/have-you-got-the-physical-form-of-your-api-under-control\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2021\/10\/API-Dev.png&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Whitepaper<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Have you got the physical form of your API under control?<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/preformulation-development\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2022\/10\/SI_Preformulation_KC_Tile.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Preformulation Development<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/crystallisation-process-development\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2022\/10\/SI_Crystallisation_KC_Tile.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Crystallisation Process Development<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\n\n<!-- <article id=\"related\">\n\t<div class=\"o-grid\">\n\t\t\t\t<div class=\"o-grid__item u-width-full u-a-center\">\n\t\t\t\t\t\t\t<h3 class=\"u-normal u-m-b4\">Related Resources<\/h3>\n\t\t\t\t\t<\/div>\n\t\n\t\t<div class=\"u-flex u-flex-justify-center u-flex-wrap u-width-full c-resources__slider js-resources-panels\">\n\t\t\t\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/leaders-in-pharma-podcast-featuring-jonathan-loughrey-and-terry-ernest\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2025\/06\/almac-physical-sciences-030-scaled.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Podcast<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Leaders in Pharma Podcast Featuring Jonathan Loughrey and Terry Ernest<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/api-chemical-development\/ensuring-consistency-in-polymorphic-drug-substances-and-products\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2020\/04\/Ensuring-Consistency-in-Polymorphic-Drug-Substances-and-Products-300x250-1.png&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">White paper<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Ensuring Consistency in Polymorphic Drug Substances and Products<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/solid-state-services-brochure\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2020\/04\/Solid-State-Services-Brochure-300x171-1.png&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Solid State Services<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/have-you-got-the-physical-form-of-your-api-under-control\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2021\/10\/API-Dev.png&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Whitepaper<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Have you got the physical form of your API under control?<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/preformulation-development\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2022\/10\/SI_Preformulation_KC_Tile.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Preformulation Development<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/crystallisation-process-development\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/analytical-solid-state\/wp-content\/uploads\/sites\/6\/2022\/10\/SI_Crystallisation_KC_Tile.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Crystallisation Process Development<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/article> -->\n","protected":false},"excerpt":{"rendered":"<p>Through the creation of synergy between solid state chemistry and formulation development, our experienced scientists have the ability to add great value to your pre-clinical project, while decreasing timelines. &nbsp; Characterisation Physical form Formulation Stability Small molecules Crystallinity Hygroscopicity Particle size, shape surface area Moisture \/ solvent content Polymorph screening Salt \/ cocrystal screening Amorphous [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-53","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Solid State Services - Analytical &amp; Solid State Services<\/title>\n<meta name=\"description\" content=\"Through Solid State Services, our experienced scientists add great value to your pre-clinical project, while decreasing timelines.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/analytical-solid-state\/solid-state-services\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" 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