{"id":67,"date":"2020-02-03T13:39:32","date_gmt":"2020-02-03T13:39:32","guid":{"rendered":"https:\/\/www.almacgroup.com\/analytical-solid-state\/?page_id=67"},"modified":"2025-02-14T11:18:08","modified_gmt":"2025-02-14T11:18:08","slug":"pre-clinical-package-small-molecules","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/analytical-solid-state\/pre-clinical-package-small-molecules\/","title":{"rendered":"Pre-Clinical Package for Small Molecules"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\">Identifying Candidates and Highlighting Potential Pitfalls<\/h4>\n\n\n\n<p>Our pre-clinical package for small molecules offers&nbsp; an intelligent, rapid, and economical approach for lead identification. Designed to identify candidates with drug product-like characteristics, it will also highlight the potential pitfalls associated with the molecules.<\/p>\n\n\n\n<p>Experimental efforts concentrate on establishing the physical \/ chemical, solubility, stability and polymorphic characteristics of each candidate. The information generated can then be used to make a rational decision for lead identification.<\/p>\n\n\n\n<div class=\"c-table__bg\"><table class=\"\"><thead><tr><td>Characterisation<\/td><td>Physical form<\/td><td>Formulation<\/td><td>Stability<\/td><\/tr><\/thead><tbody><tr><td>Crystallinity (XRPD, PLM)<br>\n Melting point (DSC)<br>\n Hygroscopicity (DVS)<br>\n Particle size and shape (microscopy)<br>\n Moisture\/Solvent content(TGA)<br>\n Log P, pKa and lipophilicity profile<br>\n Permeability (Caco-2)<\/td><td>A lean polymorph screen on each candidate to establish the polymorphic landscape and determine the tendency to form hydrates or solvates<\/td><td>Pharmaceutical solvents<br>\n Water<br>\n SGF<br>\n SIF<br>\n Saline<\/td><td>Development of stability indicating LC-MS methodSolid state stability<br>\n (heat, humidity, light)Solution stability<br>\n (pH, oxidation, heat, light)<\/td><\/tr><\/tbody><\/table><\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Timelines and Costs<\/h4>\n\n\n\n<p>It is anticipated that the pre-clinical&nbsp;package will be completed in 4 weeks. Typically, we customise studies to our clients&#8217; needs and budget.&nbsp; Quotations are available on request.<\/p>\n\n\n\n<p><a href=\"\/analytical-solid-state\/contact-us\/\" class=\"c-btn\">Contact Us<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Identifying Candidates and Highlighting Potential Pitfalls Our pre-clinical package for small molecules offers&nbsp; an intelligent, rapid, and economical approach for lead identification. Designed to identify candidates with drug product-like characteristics, it will also highlight the potential pitfalls associated with the molecules. Experimental efforts concentrate on establishing the physical \/ chemical, solubility, stability and polymorphic characteristics [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-67","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pre-Clinical Package for Small Molecules - Analytical &amp; Solid State Services<\/title>\n<meta name=\"description\" content=\"Our pre-clinical package for small molecules offers an intelligent, rapid, and economical approach for lead identification.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/analytical-solid-state\/pre-clinical-package-small-molecules\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pre-Clinical Package for Small Molecules\" \/>\n<meta property=\"og:description\" content=\"Our pre-clinical package for small molecules offers an intelligent, rapid, and economical approach for lead identification.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/analytical-solid-state\/pre-clinical-package-small-molecules\/\" \/>\n<meta property=\"og:site_name\" content=\"Analytical &amp; 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