Physical Chemistry Studies in Support of Preformulation Development

We offer the following studies to determine peptide physicochemical properties:

  • Forced degradation studies
    - Solution state stability
    - Solid state stability
  • Peptide solubility
    - pH buffers (3 to 10) suitable for use in IV formulation
    - Surface active agents (of various concentrations) suitable for use in IV formulation
    - Pharmaceutically acceptable solvents suitable for use in IV formulation
  • Provision of data to support formulation development
  • In-use stability study on preferred formulation
    - Short term chemical stability (degradation assessment)
    - Short term physical stability (solubility/precipitation assessment)
    - Assessment of impact of repeat freeze thaw cycles

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