Site-specific AF647® Labelled Chemokines

Our premium products are the AF647®^[1] labelled chemokines, which are unique to Almac.

The chemokines are labelled selectively at or near the C-terminus of the protein in a selective manner which ensures that only a single dye molecule is incorporated. The bright AF647® dye enables straightforward use in applications such as flow cytometry^[2], and receptor recognition^[3] studies.

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[1] AF647®-labelled chemokines are licensed for research use under patents or patent applications owned by Molecular Probes. [2] Hatse et al (2006). “Stromal cell-derived factor 1 (CXCL12) binds to endothelial cells and signals through a receptor different from CXCR”. Biochemical and Biophysical Research Communications 348, 192-199. [3] Strong et al (2006). “Synthetic chemokines directly labeled with a fluorescent dye as tools for studying chemokine and chemokine receptor interactions”. Eur.Cytokine Netw., 17 (1), 49-59.