{"id":21,"date":"2020-01-30T09:14:05","date_gmt":"2020-01-30T09:14:05","guid":{"rendered":"https:\/\/www.almacgroup.com\/api-chemical-development\/?page_id=21"},"modified":"2025-11-19T09:11:02","modified_gmt":"2025-11-19T09:11:02","slug":"linkers-for-drug-conjugates","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/api-chemical-development\/late-phase-api-development-and-manufacture\/linkers-for-drug-conjugates\/","title":{"rendered":"Linkers for Drug Conjugates"},"content":{"rendered":"\n<p>Almac has a wealth of experience in the development and manufacture of linker technologies used in the manufacture of antibody (or protein) drug conjugates (ADC) from early phase to late phase \/ commercial supply.&nbsp; Almac\u2019s expertise in the process and analytical development of both small and large molecules means we are uniquely positioned to deliver the best solutions for our clients.&nbsp; These molecules require excellence in organic \/ peptide chemistry, purification technology expertise, and superior analytical tools to ensure regulatory submissions proceed smoothly.&nbsp; We have independently developed expertise in these areas and can efficiently develop and validate required methods in-house.<\/p>\n\n\n\n<p>Having developed and manufactured commercial products in this space further demonstrates our proven capability to support clients through to successful market launch.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-conjugation-expertise\">Conjugation expertise<\/h4>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"248\" data-src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-1024x248.png\" alt=\"\" class=\"wp-image-53825 lazyload\" data-srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-1024x248.png 1024w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-300x73.png 300w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-768x186.png 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-1536x372.png 1536w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-1440x349.png 1440w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-480x116.png 480w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4.png 1548w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/248;\" \/><noscript><img decoding=\"async\" width=\"1024\" height=\"248\" src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-1024x248.png\" alt=\"\" class=\"wp-image-53825\" srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-1024x248.png 1024w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-300x73.png 300w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-768x186.png 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-1536x372.png 1536w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-1440x349.png 1440w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4-480x116.png 480w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2025\/07\/Linkers-for-Drug_4.png 1548w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><\/figure>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Conjugation can be achieved using a wide variety of linkages in the target molecule exploiting cysteine or lysine residues. We have proven expertise in the conjugation of peptides to a wide variety substrates and payloads. Besides the classical maleimide, disulfide, hydrazine and amide chemistries, Almac has built a strong foundation in versatile conjugation approaches such as azide-alkyne click cycloadditions, metathesis, and native chemical ligation, to name but a few.<\/p>\n\n\n\n<p>Our GMP team has successfully produced linkers, heterodipeptide conjugates (e.g. peptide1-PEG-peptide2), or peptide-chelator constructs for radiopharmaceuticals. The Almac R&amp;D group routinely showcase their excellence in the synthesis of peptides connected to proteins (BSA, Ubiquitin, KLH,\u2026), fluorescent probes, or chelators; and synthetic chemokines and histones conjugated to various dyes.<\/p>\n\n\n\n<p>This expertise comes with the right equipment and technologies to support manufacture: SPPS and bulk reactors, flow chemistry and enzymatic techniques to support conjugation; UF\/DF for purification; complete in-house large molecule analysis capabilities.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t<div class=\"\">\n\t\t<div class=\"o-wrapper\">\n\t\t\t<div class=\"o-grid\">\n\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t\t<div class=\"s-cms\">\n\t\t\t\t\t\t<h3>Make an enquiry<\/h3>\n\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\n","protected":false},"excerpt":{"rendered":"<p>Almac has a wealth of experience in the development and manufacture of linker technologies used in the manufacture of antibody (or protein) drug conjugates (ADC) from early phase to late phase \/ commercial supply.&nbsp; Almac\u2019s expertise in the process and analytical development of both small and large molecules means we are uniquely positioned to deliver [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":17,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-21","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Linkers for Drug Conjugates - API Services &amp; Chemical Development<\/title>\n<meta name=\"description\" content=\"Our expert team, from small and large molecule groups, have implemented an ADC project that ensures all challenges are anticipated and met.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/api-chemical-development\/late-phase-api-development-and-manufacture\/linkers-for-drug-conjugates\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Linkers for Drug Conjugates\" \/>\n<meta property=\"og:description\" content=\"Our expert team, from small and large molecule groups, have implemented an ADC project that ensures all challenges are anticipated and met.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/api-chemical-development\/late-phase-api-development-and-manufacture\/linkers-for-drug-conjugates\/\" \/>\n<meta property=\"og:site_name\" content=\"API Services &amp; 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