{"id":50887,"date":"2020-02-03T15:32:25","date_gmt":"2020-02-03T15:32:25","guid":{"rendered":"https:\/\/www.almacgroup.com\/api-chemical-development\/?page_id=50887"},"modified":"2025-05-09T15:32:42","modified_gmt":"2025-05-09T14:32:42","slug":"site-specific-af647-labelled-chemokines","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/api-chemical-development\/site-specific-af647-labelled-chemokines\/","title":{"rendered":"Site-specific AF647\u00ae Labelled Chemokines"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\" id=\"h-site-specific-af647-labelled-chemokines\">Site-specific AF647\u00ae Labelled Chemokines<\/h2>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-our-premium-products-are-the-af647-1-labelled-chemokines-which-are-unique-to-almac\">Our premium products are the AF647\u00ae<sup>[1]<\/sup>&nbsp;labelled chemokines, which are unique to Almac. <\/h4>\n\n\n\n<p>The chemokines are labelled selectively at or near the\u00a0<em>C<\/em>-terminus of the protein in a selective manner which ensures that only a single dye molecule is incorporated. The bright AF647\u00ae dye enables straightforward use in applications such as flow cytometry<sup>[2]<\/sup>, and receptor recognition<sup>[3]<\/sup>\u00a0studies.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"cms-table__border--black u-c-black u-bg-table--white\"><thead><tr class=\"u-bg-table--black\"><td class=\"u-p-y2 has-text-align-center\" data-align=\"center\">&nbsp;<strong>Chemokine Ligand<\/strong><\/td><td class=\"u-p-y2 has-text-align-center\" data-align=\"center\"><strong>Chemokine Name<\/strong><\/td><td class=\"has-text-align-center u-p-y2\" data-align=\"center\"><strong>Receptors<\/strong><\/td><td class=\"has-text-align-center u-p-y2\" data-align=\"center\"><strong>Catalogue code<\/strong><br>(Click to visit shop)<\/td><\/tr><\/thead><tbody><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL1<\/td><td class=\"has-text-align-center\" data-align=\"center\">I-309<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR8<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-i-309-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-7<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL2<\/td><td class=\"has-text-align-center\" data-align=\"center\">MCP-1<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR2<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mcp-1-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-2<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL3<\/td><td class=\"has-text-align-center\" data-align=\"center\">MIP-1\u03b1<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR1\/CCR5<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mip-1a-af647r-ccl3-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-1<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL4<\/td><td class=\"has-text-align-center\" data-align=\"center\">h-MIP-1-beta<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR5<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mip-1b-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-23<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL5<\/td><td class=\"has-text-align-center\" data-align=\"center\">RANTES<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR1\/CCR3\/CCR4\/CCR5<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-rantes-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-8<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL8<\/td><td class=\"has-text-align-center\" data-align=\"center\">h-MCP-2<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR1\/CCR2\/CCR3\/CCR5<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mcp-2-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-18<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL11<\/td><td class=\"has-text-align-center\" data-align=\"center\">Eotaxin<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR3<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-eotaxin-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-3<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL15<\/td><td class=\"has-text-align-center\" data-align=\"center\">MIP-5<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR1\/CCR3<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mip-5-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-19<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL17<\/td><td class=\"has-text-align-center\" data-align=\"center\">h-TARC<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR4<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-tarc-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-16<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL18<\/td><td class=\"has-text-align-center\" data-align=\"center\">PARC<\/td><td class=\"has-text-align-center\" data-align=\"center\">Unknown<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-parc-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-21<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL19<\/td><td class=\"has-text-align-center\" data-align=\"center\">MIP-3\u03b2<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR7<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mip-3b-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-6<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL20<\/td><td class=\"has-text-align-center\" data-align=\"center\">MIP-3\u03b1<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR6<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mip-3a-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-5<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL22<\/td><td class=\"has-text-align-center\" data-align=\"center\">MDC<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR4<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mdc-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-4<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL25<\/td><td class=\"has-text-align-center\" data-align=\"center\">TECK<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR9<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-teck-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-15<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CCL28<\/td><td class=\"has-text-align-center\" data-align=\"center\">h-MEC<\/td><td class=\"has-text-align-center\" data-align=\"center\">CCR10<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-mec-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-20<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CXCL8<\/td><td class=\"has-text-align-center\" data-align=\"center\">IL-8<\/td><td class=\"has-text-align-center\" data-align=\"center\">CXCR1\/CXCR2<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-il-8-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-9<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CXCL10<\/td><td class=\"has-text-align-center\" data-align=\"center\">IP-10<\/td><td class=\"has-text-align-center\" data-align=\"center\">CXCR3<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-ip-10-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-10<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CXCL11<\/td><td class=\"has-text-align-center\" data-align=\"center\">ITAC<\/td><td class=\"has-text-align-center\" data-align=\"center\">CXCR3<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-itac-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-13<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CXCL12<\/td><td class=\"has-text-align-center\" data-align=\"center\">SDF-1\u03b1<\/td><td class=\"has-text-align-center\" data-align=\"center\">CXCR4<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-sdf-1a-af647r-synthetic-100ug\">CAF-11<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CXCL12<\/td><td class=\"has-text-align-center\" data-align=\"center\">SDF-1\u03b2<\/td><td class=\"has-text-align-center\" data-align=\"center\">CXCR4<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-sdf-1b-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-22<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CXCL13<\/td><td class=\"has-text-align-center\" data-align=\"center\">MLC<\/td><td class=\"has-text-align-center\" data-align=\"center\">CXCR5<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-blc-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-12<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CXCL14<\/td><td class=\"has-text-align-center\" data-align=\"center\">BRAK<\/td><td class=\"has-text-align-center\" data-align=\"center\">Unknown<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-brak-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-17<\/a><\/td><\/tr><tr><td class=\"has-text-align-center\" data-align=\"center\">CX3CL1<\/td><td class=\"has-text-align-center\" data-align=\"center\">Fractalktine<\/td><td class=\"has-text-align-center\" data-align=\"center\">CX3CR1<\/td><td class=\"has-text-align-center\" data-align=\"center\"><a href=\"https:\/\/shop.almacgroup.com\/h-fractalkine-af647r-synthetic-100ug\" target=\"_blank\" rel=\"noreferrer noopener\">CAF-14<\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n<style>\n.wp-block-table {\n      overflow-x: visible;\n  }\n.wp-block-table table td a {\n    color: #e63329;\n    text-decoration: underline;\n}\n@media only screen and (max-width: 768px) {\n  .wp-block-table {\n      overflow-x: auto;\n  }\n}\n<\/style>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h-complete-the-form-below-to-make-an-enquiry\">Complete the form below to make an enquiry<\/h3>\n\n\n\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p style=\"font-size:12px\">[1] AF647\u00ae-labelled chemokines are licensed for research use under patents or patent applications owned by Molecular Probes. [2] Hatse et al (2006). \u201cStromal cell-derived factor 1 (CXCL12) binds to endothelial cells and signals through a receptor different from CXCR\u201d. Biochemical and Biophysical Research Communications 348, 192-199. [3] Strong et al (2006). \u201cSynthetic chemokines directly labeled with a fluorescent dye as tools for studying chemokine and chemokine receptor interactions\u201d. Eur.Cytokine Netw., 17 (1), 49-59.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Site-specific AF647\u00ae Labelled Chemokines Our premium products are the AF647\u00ae[1]&nbsp;labelled chemokines, which are unique to Almac. The chemokines are labelled selectively at or near the\u00a0C-terminus of the protein in a selective manner which ensures that only a single dye molecule is incorporated. The bright AF647\u00ae dye enables straightforward use in applications such as flow cytometry[2], [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-50887","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Site-specific AF647\u00ae Labelled Chemokines - API Services &amp; Chemical Development<\/title>\n<meta name=\"description\" content=\"Our premium site-specific AF647\u00ae labelled chemokines offers straightforward use in flow cytometry and receptor recognition studies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/api-chemical-development\/site-specific-af647-labelled-chemokines\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Site-specific AF647\u00ae Labelled Chemokines\" \/>\n<meta property=\"og:description\" content=\"Our premium site-specific AF647\u00ae labelled chemokines offers straightforward use in flow cytometry and receptor recognition studies.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/api-chemical-development\/site-specific-af647-labelled-chemokines\/\" \/>\n<meta property=\"og:site_name\" content=\"API Services &amp; 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