{"id":53342,"date":"2024-03-21T16:20:17","date_gmt":"2024-03-21T16:20:17","guid":{"rendered":"https:\/\/www.almacgroup.com\/api-chemical-development\/?page_id=53342"},"modified":"2025-03-11T15:25:00","modified_gmt":"2025-03-11T15:25:00","slug":"rational-enzyme-design","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/api-chemical-development\/rational-enzyme-design\/","title":{"rendered":"Rational Enzyme Design"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\" id=\"h-8-12-weeks-100-200-mutants\"><strong>(8 \u2013 12 weeks 100 \u2013 200 mutants)<\/strong><\/h3>\n\n\n\n<p>Molecular modelling, molecular docking, molecular dynamics, quantum mechanics and bioinformatic tools are used to sample the sequence space of the enzyme with the goal of rationally designing mutants with improved activity, selectivity, specificity and stability. All mutants are cloned, expressed and screened individually for improvements for the reaction of interest.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"1702\" height=\"3242\" data-src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL.png\" alt=\"\" class=\"wp-image-53374 lazyload\" data-srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL.png 1702w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-157x300.png 157w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-538x1024.png 538w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-768x1463.png 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-806x1536.png 806w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-1075x2048.png 1075w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-294x560.png 294w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-168x320.png 168w\" data-sizes=\"(max-width: 1702px) 100vw, 1702px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1702px; --smush-placeholder-aspect-ratio: 1702\/3242;\" \/><noscript><img decoding=\"async\" width=\"1702\" height=\"3242\" src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL.png\" alt=\"\" class=\"wp-image-53374\" srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL.png 1702w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-157x300.png 157w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-538x1024.png 538w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-768x1463.png 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-806x1536.png 806w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-1075x2048.png 1075w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-294x560.png 294w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/rational_design_enzyme_engineering_page_figure_FINAL-168x320.png 168w\" sizes=\"(max-width: 1702px) 100vw, 1702px\" \/><\/noscript><\/figure>\n\n\n\n<style>#j-content > .o-grid {\n    display: flex;\n    flex-direction: row-reverse;\n}<\/style>\n","protected":false},"excerpt":{"rendered":"<p>(8 \u2013 12 weeks 100 \u2013 200 mutants) Molecular modelling, molecular docking, molecular dynamics, quantum mechanics and bioinformatic tools are used to sample the sequence space of the enzyme with the goal of rationally designing mutants with improved activity, selectivity, specificity and stability. All mutants are cloned, expressed and screened individually for improvements for the [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-53342","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Rational Enzyme Design - API Services &amp; Chemical Development<\/title>\n<meta name=\"description\" content=\"All mutants are cloned, expressed and screened individually for improvements for the reaction of interest. 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