{"id":53354,"date":"2024-03-21T16:20:45","date_gmt":"2024-03-21T16:20:45","guid":{"rendered":"https:\/\/www.almacgroup.com\/api-chemical-development\/?page_id=53354"},"modified":"2025-02-21T14:41:43","modified_gmt":"2025-02-21T14:41:43","slug":"directed-evolution","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/api-chemical-development\/directed-evolution\/","title":{"rendered":"Directed Evolution"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\" id=\"h-3-mth-packages-multiple-rounds-of-directed-evolution\"><strong>3 mth packages > Multiple rounds of directed evolution<\/strong><\/h3>\n\n\n\n<p>Directed evolution by both site-specific and random mutagenesis. Use of robotics and high throughput screening methodologies to screen 10,000s of mutants for desired improvements. Rapid sequencing and In silico analysis of improved mutant positions to identify alternative superior amino acids at that position and the likelihood of successful additive combination with previously identified mutants.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"1744\" height=\"2268\" data-src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram.png\" alt=\"\" class=\"wp-image-53370 lazyload\" style=\"--smush-placeholder-width: 1744px; --smush-placeholder-aspect-ratio: 1744\/2268;width:840px;height:auto\" data-srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram.png 1744w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-231x300.png 231w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-787x1024.png 787w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-768x999.png 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-1181x1536.png 1181w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-1575x2048.png 1575w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-431x560.png 431w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-246x320.png 246w\" data-sizes=\"(max-width: 1744px) 100vw, 1744px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" \/><noscript><img decoding=\"async\" width=\"1744\" height=\"2268\" src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram.png\" alt=\"\" class=\"wp-image-53370\" style=\"width:840px;height:auto\" srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram.png 1744w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-231x300.png 231w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-787x1024.png 787w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-768x999.png 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-1181x1536.png 1181w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-1575x2048.png 1575w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-431x560.png 431w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/directed_evolution-diagram-246x320.png 246w\" sizes=\"(max-width: 1744px) 100vw, 1744px\" \/><\/noscript><\/figure>\n\n\n\n<style>#j-content > .o-grid {\n    display: flex;\n    flex-direction: row-reverse;\n}<\/style>\n","protected":false},"excerpt":{"rendered":"<p>3 mth packages > Multiple rounds of directed evolution Directed evolution by both site-specific and random mutagenesis. Use of robotics and high throughput screening methodologies to screen 10,000s of mutants for desired improvements. Rapid sequencing and In silico analysis of improved mutant positions to identify alternative superior amino acids at that position and the likelihood [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-53354","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Directed Evolution - API Services &amp; Chemical Development<\/title>\n<meta name=\"description\" content=\"Directed evolution by both site-specific and random mutagenesis. 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