{"id":53359,"date":"2024-03-21T16:20:57","date_gmt":"2024-03-21T16:20:57","guid":{"rendered":"https:\/\/www.almacgroup.com\/api-chemical-development\/?page_id=53359"},"modified":"2025-02-14T11:46:42","modified_gmt":"2025-02-14T11:46:42","slug":"ai-assisted-enzyme-design","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/api-chemical-development\/ai-assisted-enzyme-design\/","title":{"rendered":"AI-assisted Enzyme Design"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\" id=\"h-ai-assisted-enzyme-design\"><strong><strong>AI-assisted Enzyme Design<\/strong><\/strong><\/h3>\n\n\n\n<p>At Almac we are employing AI methods to better explore the enzyme&#8217;s fitness landscapes for reactions of interest. Structural determination and physics-based methods are used in conjunction with AI methods. Properties that are improved include activity, selectivity, thermostability, pH and solvent tolerance. Structure-based deep learning methods are also being applied to identify substrate-enzyme interactions.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-image size-full\"><img decoding=\"async\" width=\"1744\" height=\"2286\" data-src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram.png\" alt=\"\" class=\"wp-image-53372 lazyload\" data-srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram.png 1744w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-229x300.png 229w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-781x1024.png 781w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-768x1007.png 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-1172x1536.png 1172w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-1562x2048.png 1562w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-427x560.png 427w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-244x320.png 244w\" data-sizes=\"(max-width: 1744px) 100vw, 1744px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1744px; --smush-placeholder-aspect-ratio: 1744\/2286;\" \/><noscript><img decoding=\"async\" width=\"1744\" height=\"2286\" src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram.png\" alt=\"\" class=\"wp-image-53372\" srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram.png 1744w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-229x300.png 229w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-781x1024.png 781w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-768x1007.png 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-1172x1536.png 1172w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-1562x2048.png 1562w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-427x560.png 427w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/03\/AI_assisted_enzyme-diagram-244x320.png 244w\" sizes=\"(max-width: 1744px) 100vw, 1744px\" \/><\/noscript><\/figure>\n\n\n\n<style>#j-content > .o-grid {\n    display: flex;\n    flex-direction: row-reverse;\n}<\/style>\n","protected":false},"excerpt":{"rendered":"<p>AI-assisted Enzyme Design At Almac we are employing AI methods to better explore the enzyme&#8217;s fitness landscapes for reactions of interest. Structural determination and physics-based methods are used in conjunction with AI methods. Properties that are improved include activity, selectivity, thermostability, pH and solvent tolerance. Structure-based deep learning methods are also being applied to identify [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-53359","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AI-assisted Enzyme Design - API Services &amp; Chemical Development<\/title>\n<meta name=\"description\" content=\"At Almac we are employing AI methods to better explore the enzyme\u2019s fitness landscapes for reactions of interest.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/api-chemical-development\/ai-assisted-enzyme-design\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AI-assisted Enzyme Design\" \/>\n<meta property=\"og:description\" content=\"At Almac we are employing AI methods to better explore the enzyme\u2019s fitness landscapes for reactions of interest.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/api-chemical-development\/ai-assisted-enzyme-design\/\" \/>\n<meta property=\"og:site_name\" content=\"API Services &amp; 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