{"id":53475,"date":"2024-09-27T14:58:53","date_gmt":"2024-09-27T13:58:53","guid":{"rendered":"https:\/\/www.almacgroup.com\/api-chemical-development\/?page_id=53475"},"modified":"2025-03-05T17:02:38","modified_gmt":"2025-03-05T17:02:38","slug":"ai-assisted-enzyme-discovery-2","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/api-chemical-development\/insight-enzyme-databases\/ai-assisted-enzyme-discovery-2\/","title":{"rendered":"AI-assisted enzyme discovery"},"content":{"rendered":"\n<p>We employ AI methods to explore enzyme fitness landscapes for reactions of interest. Structural determination and physics-based methods are used in conjunction with AI methods. Properties which can be improved include activity, selectivity, thermostability, pH tolerance and solvent tolerance.<\/p>\n\n\n\n<p>Structure-based deep learning methods are also being developed to identify substrate-enzyme interactions.<\/p>\n\n\n\t<div class=\"\">\n\t\t<div class=\"o-wrapper\">\n\t\t\t<div class=\"o-grid\">\n\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t\t<div class=\"s-cms\">\n\t\t\t\t\t\t<div class=\"u-hidden@m u-m-b3\"><img decoding=\"async\" width=\"1024\" height=\"717\" data-src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1.jpg\" alt=\"\" class=\"alignnone size-medium wp-image-53478 lazyload\" data-srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1.jpg 1024w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1-300x210.jpg 300w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1-768x538.jpg 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1-800x560.jpg 800w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1-457x320.jpg 457w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/717;\" \/><noscript><img decoding=\"async\" width=\"1024\" height=\"717\" src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1.jpg\" alt=\"\" class=\"alignnone size-medium wp-image-53478\" srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1.jpg 1024w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1-300x210.jpg 300w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1-768x538.jpg 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1-800x560.jpg 800w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_3000dpi-1024x717-1-457x320.jpg 457w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><\/div>\n<div class=\"u-hidden u-block@m u-m-b3@m\">\n<figure id=\"attachment_53520\" aria-describedby=\"caption-attachment-53520\" style=\"width: 300px\" class=\"wp-caption alignnone\"><img decoding=\"async\" width=\"1168\" height=\"1118\" data-src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1.jpeg\" alt=\"\"  class=\"size-medium wp-image-53520 lazyload\" data-srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1.jpeg 1168w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-300x287.jpeg 300w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-1024x980.jpeg 1024w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-768x735.jpeg 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-585x560.jpeg 585w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-334x320.jpeg 334w\" data-sizes=\"(max-width: 1168px) 100vw, 1168px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1168px; --smush-placeholder-aspect-ratio: 1168\/1118;\" \/><noscript><img decoding=\"async\" width=\"1168\" height=\"1118\" src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1.jpeg\" alt=\"\"  class=\"size-medium wp-image-53520\" srcset=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1.jpeg 1168w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-300x287.jpeg 300w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-1024x980.jpeg 1024w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-768x735.jpeg 768w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-585x560.jpeg 585w, https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/machine_learning_figure_portrait_3000dpi-3-1-334x320.jpeg 334w\" sizes=\"(max-width: 1168px) 100vw, 1168px\" \/><\/noscript><figcaption id=\"caption-attachment-53520\" class=\"wp-caption-text\">Created with GIMP<\/figcaption><\/figure>\n<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\n\n\n\n<style>\n#j-content > .o-grid {\n      display: flex;\n      flex-direction: row-reverse;\n    }\n@media only screen and (max-width: 768px) {\n    #j-content > .o-grid {      \n      flex-direction: column-reverse;\n    }\n}\n<\/style>\n\n\n            <div class=\"o-wrapper\">\n            <div class=\"o-grid\">\n                <div class=\"o-grid__item u-width-full\">\n                    <article class=\"c-enquiry\">\n                                                    <aside>\n                                <img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/enzyme-engineering_image-2.png\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" style=\"--smush-placeholder-width: 406px; --smush-placeholder-aspect-ratio: 406\/230;\"><noscript><img decoding=\"async\" src=\"https:\/\/www.almacgroup.com\/api-chemical-development\/wp-content\/uploads\/sites\/4\/2024\/09\/enzyme-engineering_image-2.png\" alt=\"\"><\/noscript>\n                            <\/aside>\n                                                <section>\n                            <h3>Publications<\/h3>\n                            <div class=\"c-enquiry__text\"><p>Examples of where Almac enzyme engineering technology has been used to improve an enzyme<\/p>\n<\/div>\n\n                            \n\n    <div class=\"  u-m-t-auto \">\n                            <a class=\"c-btn c-btn-primary c-btn--red\" href=\"\/api-chemical-development\/enzyme-engineering\/publications\/\">Find out more<\/a>\n                    <\/div>\n\n                        <\/section>\n                    <\/article>\n                <\/div>\n            <\/div>\n        <\/div>\n    ","protected":false},"excerpt":{"rendered":"<p>We employ AI methods to explore enzyme fitness landscapes for reactions of interest. Structural determination and physics-based methods are used in conjunction with AI methods. Properties which can be improved include activity, selectivity, thermostability, pH tolerance and solvent tolerance. Structure-based deep learning methods are also being developed to identify substrate-enzyme interactions.<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":52993,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-53475","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>AI-assisted enzyme discovery - API Services &amp; Chemical Development<\/title>\n<meta name=\"description\" content=\"Structural determination and physics-based methods are used with AI methods to explore enzyme fitness landscapes for reactions of interest.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/api-chemical-development\/insight-enzyme-databases\/ai-assisted-enzyme-discovery-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"AI-assisted enzyme discovery\" \/>\n<meta property=\"og:description\" content=\"Structural determination and physics-based methods are used with AI methods to explore enzyme fitness landscapes for reactions of interest.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/api-chemical-development\/insight-enzyme-databases\/ai-assisted-enzyme-discovery-2\/\" \/>\n<meta property=\"og:site_name\" content=\"API Services &amp; 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