Molecular Subgroup of Primary Prostate Cancer Presenting with Metastatic Biology – European Journal of Urology
Approximately 4–25% of patients with early prostate cancer develop disease recurrence following radical prostatectomy.
To identify a molecular subgroup of prostate cancers with metastatic potential at presentation resulting in a high risk of recurrence following radical prostatectomy
A molecular subgroup of primary prostate cancer with biology similar to metastatic disease was identified. A 70-transcript signature (metastatic assay) was developed and independently validated in the radical prostatectomy samples.
The metastatic assay may identify a molecular subgroup of primary prostate cancers with metastatic potential.Download file