I-O

Almac’s Predictive Assay for Immuno-Oncology

This gene expression based assay identifies a molecular subgroup of cancers that exhibit activation of immune checkpoint proteins such as PD-L1 and ID01, which results in immune system evasion and cancer cell survival.

Almac is developing this assay as a means of prospectively identifying patients likely to respond to PD-L1 targeted therapies.

 

This assay has the potential to be used as a companion diagnostic for immune checkpoint inhibitor based therapy across a range of disease areas.

Validation of the underlying biology which connects immune checkpoint activation to DNA damage has been published in the Journal of the National Cancer Institute.

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Assessment of the Almac I-O Assay can be made through use of Almac Diagnostics Services unique gene expression report, claraT.This provides visualisation of the I-O Assay scores as an easy-to-interpret graduated bar.

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