{"id":1128,"date":"2020-03-17T13:44:49","date_gmt":"2020-03-17T13:44:49","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?post_type=diagnostic_resource&#038;p=1128"},"modified":"2020-03-17T13:44:50","modified_gmt":"2020-03-17T13:44:50","slug":"dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response","status":"publish","type":"diagnostic_resource","link":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/","title":{"rendered":"DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response"},"content":{"rendered":"\n<p><strong>Key Findings:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>DNA damage response deficient human breast cancers are associated with CD8+ and CD4+ lymphocytic infiltration.<\/li><li>The epithelial component of DDRD tumors releases chemokines that can account for lymphocytic infiltration.<\/li><li>Chemokine release is dependent on activation of the cGAS-STING-IRF3 pathway which is constitutively activated in DNA repair deficient cells, or by exogenous DNA damaging agents.<\/li><li>Activation of the cGAS-STING-IRF3 pathway is cell cycle specific and is associated with an accumulation of cytosolic DNA in the S-phase of the cell cycle.<\/li><li>Activation of the cGAS-STING-IRF3 pathway is associated with expression of the immune-checkpointinggene PD-L1 which may prevent immune-mediated tumorcell death.<\/li><li>This may provide a therapeutic rationale for immune-checkpoint targeted therapies in the context of DNA damage response deficiency in cancer.<\/li><\/ul>\n\n\n\n<p><a href=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2016\/02\/DNA-Damage-Response-Deficiency-DDRD-in-Breast-Cancer-is-associated-with-a-STING-dependent-Innate-Immune-Response_AACR-NCI-EORTC_Nov2016-2.pdf\">Click here to read more<\/a><\/p>\n","protected":false},"featured_media":0,"template":"","diagnostics_type":[476],"class_list":["post-1128","diagnostic_resource","type-diagnostic_resource","status-publish","hentry","diagnostics_type-diagnostics-posters"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response - Diagnostic Services<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response\" \/>\n<meta property=\"og:description\" content=\"Key Findings: DNA damage response deficient human breast cancers are associated with CD8+ and CD4+ lymphocytic infiltration. The epithelial component of DDRD tumors releases chemokines that can account for lymphocytic infiltration. Chemokine release is dependent on activation of the cGAS-STING-IRF3 pathway which is constitutively activated in DNA repair deficient cells, or by exogenous DNA damaging [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/\" \/>\n<meta property=\"og:site_name\" content=\"Diagnostic Services\" \/>\n<meta property=\"article:modified_time\" content=\"2020-03-17T13:44:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/11\/Almac_Logo-e1698941154737.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"100\" \/>\n\t<meta property=\"og:image:height\" content=\"52\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/\",\"name\":\"DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response - Diagnostic Services\",\"isPartOf\":{\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/#website\"},\"datePublished\":\"2020-03-17T13:44:49+00:00\",\"dateModified\":\"2020-03-17T13:44:50+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.almacgroup.com\/diagnostics\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/#website\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/\",\"name\":\"Diagnostic Services\",\"description\":\"Just another Almac Core Sites site\",\"publisher\":{\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.almacgroup.com\/diagnostics\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/#organization\",\"name\":\"Almac Group Ltd\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/04\/almac-logo-with-strapline.jpg\",\"contentUrl\":\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/04\/almac-logo-with-strapline.jpg\",\"width\":643,\"height\":296,\"caption\":\"Almac Group Ltd\"},\"image\":{\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response - Diagnostic Services","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/","og_locale":"en_GB","og_type":"article","og_title":"DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response","og_description":"Key Findings: DNA damage response deficient human breast cancers are associated with CD8+ and CD4+ lymphocytic infiltration. The epithelial component of DDRD tumors releases chemokines that can account for lymphocytic infiltration. Chemokine release is dependent on activation of the cGAS-STING-IRF3 pathway which is constitutively activated in DNA repair deficient cells, or by exogenous DNA damaging [&hellip;]","og_url":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/","og_site_name":"Diagnostic Services","article_modified_time":"2020-03-17T13:44:50+00:00","og_image":[{"width":100,"height":52,"url":"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/11\/Almac_Logo-e1698941154737.jpeg","type":"image\/jpeg"}],"twitter_card":"summary_large_image","twitter_misc":{"Estimated reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/","url":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/","name":"DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response - Diagnostic Services","isPartOf":{"@id":"https:\/\/www.almacgroup.com\/diagnostics\/#website"},"datePublished":"2020-03-17T13:44:49+00:00","dateModified":"2020-03-17T13:44:50+00:00","breadcrumb":{"@id":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/dna-damage-response-deficiency-ddrd-in-breast-cancer-is-associated-with-a-sting-dependent-innate-immune-response\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.almacgroup.com\/diagnostics\/"},{"@type":"ListItem","position":2,"name":"DNA Damage Response Deficiency (DDRD) in Breast Cancer is associated with a STING-dependent Innate Immune Response"}]},{"@type":"WebSite","@id":"https:\/\/www.almacgroup.com\/diagnostics\/#website","url":"https:\/\/www.almacgroup.com\/diagnostics\/","name":"Diagnostic Services","description":"Just another Almac Core Sites site","publisher":{"@id":"https:\/\/www.almacgroup.com\/diagnostics\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.almacgroup.com\/diagnostics\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/www.almacgroup.com\/diagnostics\/#organization","name":"Almac Group Ltd","url":"https:\/\/www.almacgroup.com\/diagnostics\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/www.almacgroup.com\/diagnostics\/#\/schema\/logo\/image\/","url":"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/04\/almac-logo-with-strapline.jpg","contentUrl":"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/04\/almac-logo-with-strapline.jpg","width":643,"height":296,"caption":"Almac Group Ltd"},"image":{"@id":"https:\/\/www.almacgroup.com\/diagnostics\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.almacgroup.com\/diagnostics\/wp-json\/wp\/v2\/diagnostic_resource\/1128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.almacgroup.com\/diagnostics\/wp-json\/wp\/v2\/diagnostic_resource"}],"about":[{"href":"https:\/\/www.almacgroup.com\/diagnostics\/wp-json\/wp\/v2\/types\/diagnostic_resource"}],"wp:attachment":[{"href":"https:\/\/www.almacgroup.com\/diagnostics\/wp-json\/wp\/v2\/media?parent=1128"}],"wp:term":[{"taxonomy":"diagnostics_type","embeddable":true,"href":"https:\/\/www.almacgroup.com\/diagnostics\/wp-json\/wp\/v2\/diagnostics_type?post=1128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}