{"id":1155,"date":"2020-03-17T14:06:09","date_gmt":"2020-03-17T14:06:09","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?post_type=diagnostic_resource&#038;p=1155"},"modified":"2020-03-17T14:06:11","modified_gmt":"2020-03-17T14:06:11","slug":"platinum-therapy-resistance-is-associated-with-an-enrichment-of-tumour-angiogenesis-in-epithelial-ovarian-cancer","status":"publish","type":"diagnostic_resource","link":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/platinum-therapy-resistance-is-associated-with-an-enrichment-of-tumour-angiogenesis-in-epithelial-ovarian-cancer\/","title":{"rendered":"Platinum therapy resistance is associated with an enrichment of tumour angiogenesis in epithelial ovarian cancer"},"content":{"rendered":"\n<ul class=\"wp-block-list\"><li>The clinical and pre-clinical data discussed has potentially significant clinical implications in the management of treatment-relapsed HGSOC.<\/li><li>Platinum-resistance in relapsed HGSOC is an indicator for response to antiangiogenic agents.<\/li><li>The novel identification of chemotherapy-mediated selection for an angiogenic phenotype in EOC, through upregulation of the PDGFR\uf061-VEGF-A signalling pathway.<\/li><li>Targeted inhibition of PDGFR\uf061 (using TKI or siRNA knockdown) reverses platinum therapy resistance in EOC.<\/li><li>This clinical and pre-clinical data supports the use of anti-angiogenic agents in the first and second line setting in patients with innate and acquired resistance to platinum therapy, respectively.<\/li><\/ul>\n","protected":false},"featured_media":0,"template":"","diagnostics_type":[476],"class_list":["post-1155","diagnostic_resource","type-diagnostic_resource","status-publish","hentry","diagnostics_type-diagnostics-posters"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Platinum therapy resistance is associated with an enrichment of tumour angiogenesis in epithelial ovarian cancer - Diagnostic Services<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/platinum-therapy-resistance-is-associated-with-an-enrichment-of-tumour-angiogenesis-in-epithelial-ovarian-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Platinum therapy resistance is associated with an enrichment of tumour angiogenesis in epithelial ovarian cancer\" \/>\n<meta property=\"og:description\" content=\"The clinical and pre-clinical data discussed has potentially significant clinical implications in the management of treatment-relapsed HGSOC. Platinum-resistance in relapsed HGSOC is an indicator for response to antiangiogenic agents. The novel identification of chemotherapy-mediated selection for an angiogenic phenotype in EOC, through upregulation of the PDGFR\uf061-VEGF-A signalling pathway. 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