{"id":1163,"date":"2020-03-17T14:14:04","date_gmt":"2020-03-17T14:14:04","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?post_type=diagnostic_resource&#038;p=1163"},"modified":"2020-03-17T14:14:05","modified_gmt":"2020-03-17T14:14:05","slug":"platinum-based-therapy-selects-for-an-angiogenic-enriched-tumour-micro-environment-in-high-grade-serous-ovarian-cancer-2","status":"publish","type":"diagnostic_resource","link":"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/platinum-based-therapy-selects-for-an-angiogenic-enriched-tumour-micro-environment-in-high-grade-serous-ovarian-cancer-2\/","title":{"rendered":"Platinum-based therapy selects for an angiogenic enriched tumour micro-environment in High Grade Serous Ovarian Cancer"},"content":{"rendered":"\n<p><strong>Background:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li>Angiogenesis is a key pathological feature of epithelial ovarian cancer (EOC) and anti-angiogenics have dominated the field of drug development in EOC<\/li><li>There are no clinically approved predictive biomarker to preselect the subgroup of high grade serous ovarian cancer (HGSOC) that will derive benefit from anti-angiogenic therapy<\/li><li>Relapse post platinum-based therapy is associated with a beneficial response to anti-angiogenics<\/li><li>Innate and acquired platinum resistance is characterised by upregulation of VEGFa and receptor tyrosine kinase expression that trigger an enriched angiogenic tumour micro-environment<\/li><li>In-vitro and in-vivo angiogenesis assays demonstrate that platinum resistant cell lines are sensitive to Cediranib and Nintedanib<\/li><\/ol>\n\n\n\n<p><a href=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2019\/02\/Platinum-based-therapy-selects-for-an-angiogenic-enriched-tumour-micro-environment-in-High-Grade-Serous-Ovarian-Cancer.pdf\">Click here to read more<\/a><\/p>\n","protected":false},"featured_media":0,"template":"","diagnostics_type":[476],"class_list":["post-1163","diagnostic_resource","type-diagnostic_resource","status-publish","hentry","diagnostics_type-diagnostics-posters"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - 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