{"id":10,"date":"2020-01-22T09:49:07","date_gmt":"2020-01-22T09:49:07","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?page_id=10"},"modified":"2023-05-18T11:57:21","modified_gmt":"2023-05-18T10:57:21","slug":"biomarker-discovery","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/diagnostics\/clinical-trial-solutions\/biomarker-discovery\/","title":{"rendered":"Biomarker Discovery"},"content":{"rendered":"\n<p>Almac Diagnostic Services can also help Biopharma clients validate reliable&nbsp;<a href=\"\/diagnostics\/clinical-trial-solutions\/pharmacodynamic-biomarker-testing\/\">Pharmacodynamic (PD) Biomarker assays<\/a>&nbsp;that can help provide invaluable guidance within their drug development programmes.<br> <br>Almac also has extensive experience in the discovery of clinically applicable biomarkers, through our own range of Almac proprietary assays (<strong>DDIR, Prostate Dx, ColDx, Angio,&nbsp;<\/strong>and<strong>&nbsp;EMT<\/strong>) and through developing biomarkers for our partners.<\/p>\n\n\n\n<p>As part of our commercial&nbsp;<a href=\"https:\/\/www.almacgroup.com\/diagnostics\/clinical-trial-solutions\/cdx-development\/\">CDx<\/a>&nbsp;partnerships, we have discovered novel molecular pathways that have been brought forward and developed into Research Assays, Clinical Trial Assays, and full Companion Diagnostics.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-our-subtyping-approach-to-biomarker-discovery\"><strong>Our Subtyping Approach to Biomarker Discovery<\/strong><\/h4>\n\n\n\n<p>Our subtyping approach involves expertise in working with FFPE tissue, profiling large retrospective FFPE tumor datasets to identify the underlying molecular structure that allows us to subtype a range of specific disease indications. This same approach can be used for the discovery of biomarkers. Using this approach, the biology discovered represents a class effect that can often be seen across multiple disease areas and have application for multiple drugs in a particular drug class.<\/p>\n\n\n\n<p>We have used this approach for a number of our clients using cohorts that they already have available to them or by additionally supporting them in securing access to required datasets by means of our retrospective sample collection services.<\/p>\n\n\n\n<p>We have extensive experience carrying out biomarker discovery in a pre-clinical setting using various model systems. Signatures discovered in this setting have also been brought to the clinic, for trial enrichment purposes, in early phase trials.<\/p>\n\n\n\n<p>The benefits of the Almac Diagnostic Services approach to Biomarker Discovery are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Provides a fundamental biology which can link to novel therapeutic targets<\/li>\n\n\n\n<li>Can function across multiple disease areas and clinical decision points<\/li>\n\n\n\n<li>Delivers a robust assay which is easily transferable across multiple platforms<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-state-of-the-art-laboratory-technologies-and-experienced-scientists\"><strong>State-of-the-Art Laboratory Technologies and Experienced Scientists<\/strong><\/h4>\n\n\n\n<p>Our biomarker discovery services are supported by our<a href=\"\/diagnostics\/supporting-services\/platforms-technologies\/\"> state-of-the-art laboratory technologies<\/a> which are ideally suited to biomarker discovery, development and delivery in a clinical setting. We also have a team of highly qualified and experienced scientists, <a href=\"\/diagnostics\/supporting-services\/bioinformatics-biostatistics-software-development\/\">bioinformaticians, and biostatisticians<\/a> with substantial knowledge and experience in high tech molecular and cell biology technologies including NGS and multiplex qPCR, drug discovery and development and diagnostic product development.<\/p>\n\n\n\n<p>We recognise that each study is unique and has its own challenges. Our team will work with collaborators and clients throughout the project to provide a comprehensive tailored service \u2013 from initial study design and planning, all the way through to the interpretation of results, and will integrate seamlessly as part of your extended team.<\/p>\n\n\n\n<p>We offer complete transparency throughout every study, with all methodology, programs and analytical methods clearly explained and available for review. We pride ourselves on quality and we work under strict standard operating procedures. All analytical methods we use are extensively tested and verified and all results are reviewed and provided with complete information to enable independent confirmation.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-retrospective-sample-collection\"><strong>Retrospective Sample Collection<\/strong><\/h4>\n\n\n\n<p>With personalised medicine now being adopted as best practice, the majority of drugs in development have a biomarker strategy. In situations where a drug has not performed as well as hoped, a biomarker or companion diagnostic strategy could potentially rescue the drug or increase market uptake.<\/p>\n\n\n\n<p>Given the market demand, we have also developed our biomarker discovery capabilities as a service to enable biomarker discovery to be carried out retrospectively in trials originally run without a biomarker strategy and where samples were not collected in the clinical trial.<\/p>\n\n\n\n<p>Over many years\u2019, our established team of experts have honed skills in retrospective sample collection on behalf of clients. We specialise in the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sample Sourcing<\/li>\n\n\n\n<li>Obtaining ethical approval and corresponding consent<\/li>\n\n\n\n<li>Full logistical &amp; regulatory oversight of sample preparation, shipping, receipt and biobanking<\/li>\n\n\n\n<li>Identification of clinical information for patients in partnership with investigators<\/li>\n\n\n\n<li>Contractual arrangements<\/li>\n<\/ul>\n\n\n\n\n    <div class=\"  u-m-t-auto \">\n                            <a class=\"c-btn c-btn-primary c-btn--diagnostics-blue\" href=\"\/diagnostics\/contact-us\/\">Contact Us<\/a>\n                    <\/div>\n\n\n\n<div style=\"height:48px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"o-wrapper\">\n\t<div class=\"o-grid\">\n\n\t\t<div class=\"o-grid__item u-width-full \">\n\t\t\t\t\t\t\t<h2 class=\"u-m-b4\">Related resources<\/h2>\n\t\t\t\t\t<\/div>\n\n\t<\/div>\n            <div class=\"o-grid u-flex-align-stretch u-m-b3\">\n\n            \n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                                                <img decoding=\"async\" class=\"u-m-b2 lazyload\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/An-introductory-guide-to-biomarkers-precision-personalised-and-stratified-medicine-350x140-1.jpg\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 350px; --smush-placeholder-aspect-ratio: 350\/140;\"><noscript><img decoding=\"async\" class=\"u-m-b2\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/An-introductory-guide-to-biomarkers-precision-personalised-and-stratified-medicine-350x140-1.jpg\" alt=\"\"><\/noscript>\n                        \n                                                    <p class=\"c-resource__category\">Thought Leadership<\/p>\n                        \n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\">An introductory guide to biomarkers, precision, personalised and stratified medicine\r\n\r\n<\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--diag-blue\" href=\"\/diagnostic-resource\/an-introductory-guide-to-biomarkers-precision-personalised-and-stratified-medicine\/\" target=\"\">Learn more<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                                                <img decoding=\"async\" class=\"u-m-b2 lazyload\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Developing-and-Applying-Biomarkers-in-Early-Phase-Clinical-Trials-PNG-350x197-1.png\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 350px; --smush-placeholder-aspect-ratio: 350\/197;\"><noscript><img decoding=\"async\" class=\"u-m-b2\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Developing-and-Applying-Biomarkers-in-Early-Phase-Clinical-Trials-PNG-350x197-1.png\" alt=\"\"><\/noscript>\n                        \n                                                    <p class=\"c-resource__category\">Webinar<\/p>\n                        \n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\">Developing and Applying Biomarkers in Early Phase Clinical Trials<\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--diag-blue\" href=\"\/diagnostic-resource\/developing-applying-biomarkers-early-phase-clinical-trials\/\" target=\"\">Learn more<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                                                <img decoding=\"async\" class=\"u-m-b2 lazyload\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Retrospective-Sample-Collection-\u2013-Biomarker-Discovery-to-Help-Rescue-your-Drug-350x197-1.png\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 350px; --smush-placeholder-aspect-ratio: 350\/197;\"><noscript><img decoding=\"async\" class=\"u-m-b2\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Retrospective-Sample-Collection-\u2013-Biomarker-Discovery-to-Help-Rescue-your-Drug-350x197-1.png\" alt=\"\"><\/noscript>\n                        \n                                                    <p class=\"c-resource__category\">Webinar<\/p>\n                        \n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\">Retrospective Sample Collection \u2013 Biomarker Discovery to Help Rescue your Drug\r\n\r\n<\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--diag-blue\" href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/retrospective-sample-collection-biomarker-discovery-to-help-rescue-your-drug\/\" target=\"\">Learn more<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                                                <img decoding=\"async\" class=\"u-m-b2 lazyload\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Group-Announces-Publication-of-Prostate-Cancer-Metastatic-Assay-Validation-350x197-1.png\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 350px; --smush-placeholder-aspect-ratio: 350\/197;\"><noscript><img decoding=\"async\" class=\"u-m-b2\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Group-Announces-Publication-of-Prostate-Cancer-Metastatic-Assay-Validation-350x197-1.png\" alt=\"\"><\/noscript>\n                        \n                                                    <p class=\"c-resource__category\">News<\/p>\n                        \n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\">Almac Group Announces Publication of Prostate Cancer Metastatic Assay Validation<\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--diag-blue\" href=\"\/news\/almac-group-announces-publication-prostate-cancer-metastatic-assay-validation\/\" target=\"\">Learn more<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                    <\/div>\n    <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Almac Diagnostic Services can also help Biopharma clients validate reliable&nbsp;Pharmacodynamic (PD) Biomarker assays&nbsp;that can help provide invaluable guidance within their drug development programmes. Almac also has extensive experience in the discovery of clinically applicable biomarkers, through our own range of Almac proprietary assays (DDIR, Prostate Dx, ColDx, Angio,&nbsp;and&nbsp;EMT) and through developing biomarkers for our partners. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-10","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Biomarker Discovery - Diagnostic Services | validation and discovery<\/title>\n<meta name=\"description\" content=\"Biomarker Discovery - We help Biopharma clients validate reliable Pharmacodynamic (PD) Biomarker assays and have extensive experience in the discovery of clinically relevant and clinically applicable biomarkers.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/clinical-trial-solutions\/biomarker-discovery\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biomarker Discovery\" \/>\n<meta property=\"og:description\" content=\"Biomarker Discovery - 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