{"id":111,"date":"2020-01-22T11:20:14","date_gmt":"2020-01-22T11:20:14","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?page_id=111"},"modified":"2023-01-23T13:04:52","modified_gmt":"2023-01-23T13:04:52","slug":"government-support-for-research-development-programmes","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/diagnostics\/almac-diagnostic-services-overview\/government-support-for-research-development-programmes\/","title":{"rendered":"Government Support for Research &#038; Development Programmes"},"content":{"rendered":"\n<h3 class=\"wp-block-heading\">The evolution of multi-omic technologies has rapidly increased the understanding of molecular complexities of disease, driving the current trend towards the simultaneous investigation of multiple biomarkers from one panel. As a result, smarter biomarker solutions are required to meet the growing needs of our Biopharma and Academic clients.<\/h3>\n\n\n\n<p>Almac Diagnostic Service\u2019s current Research and Development (R&amp;D) Programmes are focused on DNA &amp; RNA Next Generation Sequencing (NGS) platforms to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Optimise biomarker discovery &amp; translational research.<\/li>\n\n\n\n<li>Develop robust NGS solutions for the development &amp; validation of Clinical Trial Assays.<\/li>\n\n\n\n<li>Provide multiple readouts from a single solid tumour or liquid biopsy sample.<\/li>\n<\/ul>\n\n\n\n<p>Almac Diagnostic Services has been awarded Government funding to support two R&amp;D programs designed to enhance our service offering to support our clients\u2019 drug development pipelines.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Programme One:<\/h3>\n\n\n\n<p><strong>&#8220;Development of a next generation genomics biomarker platform for immune oncology (IO) therapies&#8221;<\/strong><\/p>\n\n\n\n<p>For more information visit <strong><a href=\"\/diagnostics\/portfolio-overview\/whole-exome-sequencing\/\">Whole Exome Sequencing<\/a>.<\/strong><\/p>\n\n\n\n<p><strong>Overview:<\/strong><\/p>\n\n\n\n<p>This program consists of the establishment of a Next Generation Sequencing (NGS) and Artificial Intelligence (AI) powered biomarker platform for identification and interpretation of DNA based aberrations.<\/p>\n\n\n\n<p><strong>Deliverables:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Established robust wet and dry lab protocols for cost effective and comprehensive Whole Exome Sequencing (WES) data generation and QC, from challenging material such as Formalin Fixed Paraffin Embedded (FFPE) tissue, for biomarker discovery purposes.<\/li>\n\n\n\n<li>Proprietary Oncology and IO relevant biomarker assay pipelines, including specific variant calling, Tumour Mutation Burden (TMB) and Microsatellite Instability (MSI) biomarkers as well as Hallmarks of Cancer and resistance mechanisms, that are reported in a clear and interactive format.<\/li>\n\n\n\n<li>Validated Investigational Use Only (IUO) biomarker solution to identify multiple variants &amp; assays from FFPE material for use in prospective clinical trials.<\/li>\n<\/ol>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large\"><a href=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2019\/05\/EU-Logo.jpg\"><img decoding=\"async\" width=\"300\" height=\"128\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/EU-Logo-300x128-1.jpg\" alt=\"\" class=\"wp-image-1178 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/128;\" \/><noscript><img decoding=\"async\" width=\"300\" height=\"128\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/EU-Logo-300x128-1.jpg\" alt=\"\" class=\"wp-image-1178\"\/><\/noscript><\/a><\/figure><\/div>\n\n\n<p>This R&amp;D program is supported by an investment of \u00a3885k from Invest Northern Ireland via the Grant for R&amp;D Programme, over 3 years, from 2018 \u2013 2021. This project is part-financed by the European Regional Development Fund under the Investment for Growth and Jobs Programme 2014-2020.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\">Programme Two:<\/h3>\n\n\n\n<p><strong>&#8220;Almac&#8217;s novel biomarer platform for patient stratification within immune oncology clinical trials.&#8221;<\/strong><\/p>\n\n\n\n<p>For more information visit <strong><a href=\"\/diagnostics\/claratreport\/\">clara<sup>T<\/sup><\/a>.<\/strong><\/p>\n\n\n\n<p><strong>Overview:<\/strong><\/p>\n\n\n\n<p>This program harnesses our 15 years\u2019 experience in the discovery, development and commercialisation of gene expression (GE) based diagnostic tests. The goal is to develop and validate a comprehensive NGS platform and proprietary report that classifies gene expression signatures according to the Hallmarks of Cancer.<\/p>\n\n\n\n<p>Almac\u2019s proprietary <strong>clara<sup>T<\/sup> Total mRNA Report<\/strong> is a unique software-driven solution, classifying biologically relevant gene expression signatures into a comprehensive, easy-to-interpret report. A pan-cancer solution, based on a powerful bioinformatics pipeline, automatically generating the clara<sup>T <\/sup>report from raw gene expression data utilising the <a href=\"\/diagnostics\/rna-panel-solution\/\"><strong>Almac optimised RNA Exome Panel.<\/strong><\/a><\/p>\n\n\n\n<p><strong>Deliverables:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Established wet and dry lab protocols for cost effective and comprehensive RNA Exome Sequencing, from challenging material such as FFPE tissue, for biomarker discovery purposes.<\/li>\n\n\n\n<li>Bioinformatics pipelines to classify gene expression signatures representative of the 10 Hallmarks of Cancer (including Almac\u2019s proprietary DDIR, EMT and Angiogenesis signatures alongside publically available validated signatures).<\/li>\n\n\n\n<li>Software pipelines to report the signature outputs and single gene targets classified by the Hallmarks of Cancer in an interactive, visual manner (clara<sup>T<\/sup>).<\/li>\n\n\n\n<li>A robust platform analytically validated to IUO standard for selected key clinically actionable gene expression signatures in the Immuno-Oncology treatment setting.<\/li>\n<\/ol>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large\"><a href=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2019\/05\/Innovate-UK-Logo-copy.png\"><img decoding=\"async\" width=\"300\" height=\"133\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Innovate-UK-Logo-copy-300x133-1.png\" alt=\"\" class=\"wp-image-1179 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 300px; --smush-placeholder-aspect-ratio: 300\/133;\" \/><noscript><img decoding=\"async\" width=\"300\" height=\"133\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Innovate-UK-Logo-copy-300x133-1.png\" alt=\"\" class=\"wp-image-1179\"\/><\/noscript><\/a><\/figure><\/div>\n\n\n<p>This R&amp;D program is supported by an investment of \u00a3500K from Innovate UK, via the December 2017 Sector Competition, over three years, from 2018 &#8211; 2021.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The evolution of multi-omic technologies has rapidly increased the understanding of molecular complexities of disease, driving the current trend towards the simultaneous investigation of multiple biomarkers from one panel. As a result, smarter biomarker solutions are required to meet the growing needs of our Biopharma and Academic clients. Almac Diagnostic Service\u2019s current Research and Development [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":101,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-page-wrapper.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-111","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Government Support for Research &amp; Development Programmes - Diagnostic Services<\/title>\n<meta name=\"description\" content=\"Almac Diagnostic Services has been awarded Government funding to support two R&amp;D programs designed to enhance our service offering to support our clients\u2019 drug development pipelines.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/almac-diagnostic-services-overview\/government-support-for-research-development-programmes\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Government Support for Research &amp; Development Programmes\" \/>\n<meta property=\"og:description\" content=\"Almac Diagnostic Services has been awarded Government funding to support two R&amp;D programs designed to enhance our service offering to support our clients\u2019 drug development pipelines.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/almac-diagnostic-services-overview\/government-support-for-research-development-programmes\/\" \/>\n<meta property=\"og:site_name\" content=\"Diagnostic Services\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-23T13:04:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/EU-Logo-300x128-1.jpg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/almac-diagnostic-services-overview\/government-support-for-research-development-programmes\/\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/almac-diagnostic-services-overview\/government-support-for-research-development-programmes\/\",\"name\":\"Government Support for Research & Development Programmes - 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