{"id":1255,"date":"2020-03-20T17:20:51","date_gmt":"2020-03-20T17:20:51","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?page_id=1255"},"modified":"2025-06-11T10:34:15","modified_gmt":"2025-06-11T09:34:15","slug":"rna-sequencing-solutions","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/diagnostics\/rna-sequencing-solutions\/","title":{"rendered":"RNA-Sequencing Solutions"},"content":{"rendered":"\n<h2 class=\"wp-block-heading has-medium-font-size\">Background Information<\/h2>\n\n\n\n<p>Almac Diagnostic Services has a proven ability to discover, develop and validate high quality, innovative RNA-based biomarkers with an extensive track record in establishing assays across key regulatory standards. We currently offer multiple Research Use Only (RUO) RNA-Sequencing solutions analysed using the Illumina NextSeq500, NextSeq550, NovaSeq6000 and NovaSeq X Plus <strong><a href=\"\/diagnostics\/supporting-services\/platforms-technologies\/\">sequencing platforms<\/a><\/strong>.&nbsp; All our RNA-Sequencing solutions support novel <strong><a href=\"https:\/\/www.almacgroup.com\/diagnostics\/genomic-services\">biomarker discovery<\/a><\/strong> and translational research, supported by Almac innovative proprietary <a href=\"\/diagnostics\/supporting-services\/bioinformatics-biostatistics-software-development\/\"><strong>bioinformatics<\/strong><\/a> solutions. These include:<\/p>\n\n\n\n<div style=\"height:35px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"overflow: auto;\">\n<div class=\"u-hidden@s\" style=\"width: 690px;\"><img decoding=\"async\" class=\"aligncenter lazyload\" data-src=\"\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/rna-chart-hotspot.svg\" usemap=\"#image-map-desktop\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\"><noscript><img decoding=\"async\" class=\"aligncenter\" src=\"\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/rna-chart-hotspot.svg\" usemap=\"#image-map-desktop\"><\/noscript> \n<map name=\"image-map-desktop\"> \n\n<area title=\"RNA-Sequencing Solutions\" alt=\"RNA-Sequencing Solutions\" coords=\"169,130,-1,73\" shape=\"rect\" href=\"#rna-sequencing\" target=\"\">\n\n<area title=\"Illumina RNA Exome\" alt=\"Illumina RNA Exome\" coords=\"205,-1,367,55\" shape=\"rect\" href=\"\/diagnostics\/rna-panel-solution\/\" target=\"\">\n \n\n<area title=\"Roche Total RNASeq\" alt=\"Roche Total RNASeq\" coords=\"205,73,366,130\" shape=\"rect\" href=\"#roche\" target=\"\">\n \n\n<area title=\"Illumina mRNA Stranded\" alt=\"Illumina mRNA Stranded\" coords=\"205,147,368,202\" shape=\"rect\" href=\"#illumina-mrna\" target=\"\">\n \n\n<area title=\"ClaraT Total mRNA Report\" alt=\"ClaraT Total mRNA Report\" coords=\"411,36,593,167\" shape=\"rect\" href=\"\/diagnostics\/claratreport\/\" target=\"\">\n <\/map>\n<\/div>\n<\/div>\n<div class=\"u-hidden u-block@s\"><img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/rna-chart-hotspot-mobile.svg\" usemap=\"#image-map-mobile\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\"><noscript><img decoding=\"async\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/rna-chart-hotspot-mobile.svg\" usemap=\"#image-map-mobile\"><\/noscript> \n<map name=\"image-map-mobile\"> \n\n<area title=\"RNA-Sequencing Solutions\" alt=\"RNA-Sequencing Solutions\" coords=\"61,0,235,56\" shape=\"rect\" href=\"#rna-sequencing\" target=\"\">\n \n\n<area title=\"Illumina RNA Exome\" alt=\"Illumina RNA Exome\" coords=\"-1,91,94,177\" shape=\"rect\" href=\"#illumina\" target=\"\">\n \n\n<area title=\"Roche Total RNASeq\" alt=\"Roche Total RNASeq\" coords=\"101,93,195,177\" shape=\"rect\" href=\"#roche\" target=\"\">\n \n\n<area title=\"Illumina mRNA Stranded\" alt=\"Illumina mRNA Stranded\" coords=\"203,93,295,175\" shape=\"rect\" href=\"#illumina-mrna\" target=\"\">\n \n\n<area title=\"ClaraT Total mRNA Report\" alt=\"ClaraT Total mRNA Report\" coords=\"70,194,222,296\" shape=\"rect\" href=\"\/diagnostics\/claratreport\/\" target=\"\">\n <\/map>\n<\/div>\n\n\n\n<div style=\"height:47px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading\" id=\"h-to-find-out-more-information-on-each-almac-solution-click-the-appropriate-drop-down-below\">To find out more information on each Almac solution, click the appropriate drop-down below:<\/h4>\n\n\n<!-- Accordions -->\n<section class=\"u-bg-white u-p-y4 t-theme-component-overwrite\" id=\"accordionBlock\">\n\t<div class=\"o-wrapper\">\n\t\t<div class=\"o-grid o-grid--center\">\n\t\t\t<div class=\"o-grid__item u-width-full u-align-center u-align-left@m\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t<div class=\"u-m-t2\">\n\t\t\t\t\t<div class=\"c-accordion js-accordion\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article id=\"item1\" class=\"c-accordion__item u-c-mid-grey accordion-1\">\n\t\t\t\t\t\t        <h4 class=\"c-accordion__title u-bg-white u-c-mid-grey js-accordionTarget-one\">RNA Exome Sequencing<\/h4>\n\t\t\t\t\t\t        <div class=\"c-accordion__content u-bg-white\">\n\t\t\t\t\t\t\t\t\t<div class=\"o-grid\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if image is there then allow content to sit with it -->\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if not then content goes full width -->\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"s-cms\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p><strong><span style=\"color: #7030a0;\">RNA Exome Sequencing<\/span><\/strong><\/p>\n<p><strong>The Platform<\/strong>: RNA Exome is a probe-based target capture approach for sequencing of coding regions.\u00a0 An <strong>Almac optimised solution<\/strong> recommended for <strong>gene expression<\/strong> from poor quality and formalin-fixed paraffin embedded <strong>(FFPE) samples<\/strong>.<\/p>\n<p><strong><span style=\"color: #7030a0;\">Features &amp; Benefits:<\/span><\/strong><\/p>\n<ul>\n<li><strong>Comprehensive panel<\/strong> covering &gt;21,000 genes from the RefSeq Exome (99%)<\/li>\n<li>Almac optimised process and workflow <strong>maximising on pass rates and sequencing data quality<\/strong> from challenging sample types<\/li>\n<li>Produces <strong>highly repeatable and reproducible <\/strong>gene expression data in comparison to other RNA expression platforms<\/li>\n<li>Almac have <strong>analytically validated<\/strong> a selection of gene expression signatures demonstrating RNA Exome as a <strong>potential platform suitable for CTA delivery<\/strong><\/li>\n<\/ul>\n<div class=\"c-diag-table-wrap\">\n<table>\n<tbody>\n<tr>\n<th style=\"background-color: #7030a0;\">Metric<\/th>\n<th style=\"background-color: #7030a0;\">RNA Exome Solution<\/th>\n<\/tr>\n<tr>\n<td>Chemistry<\/td>\n<td>Illumina TruSeq\u2122 RNA Exome<\/td>\n<\/tr>\n<tr>\n<td>Tissue Type<\/td>\n<td>Optimised for FFPE<\/td>\n<\/tr>\n<tr>\n<td>Recommended Tissue Requirements<\/td>\n<td>For FFPE, tissue should be macrodissected<br \/>\n10 x 5 \u00b5m FFPE sections with a tissue area &gt;1cm<sup>2<\/sup> and high tumour content &gt;10% viable cells<br \/>\nSpecific guidelines will be provided on a per-project basis<\/td>\n<\/tr>\n<tr>\n<td>Recommended RNA Input<\/td>\n<td>Recommended Minimum 100 ng<br \/>\n(100-500 ng dependent on quality based on DV<sub>200<\/sub>)<\/td>\n<\/tr>\n<tr>\n<td>Standard Sequencing Specification<\/td>\n<td>25M PE reads (50M Total Reads)<br \/>\n<span style=\"font-family: inherit; font-size: inherit;\">Other Sequencing specifications available on request<\/span><\/td>\n<\/tr>\n<tr>\n<td>Deliverables<\/td>\n<td>FASTQ, FPKM Expression Matrix, Count Matrix and QC Report as standard.\u00a0 BAM files on request<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h6><strong>NOTE:<\/strong> Optimal sample number \u226524 samples<\/h6>\n<\/div>\n<p style=\"text-align: center;\"><span style=\"font-family: 'trebuchet ms', geneva; font-weight: bold;\"><a style=\"color: #ffffff; background: #7030a0; text-decoration: none; border: 2px solid #7030a0; border-radius: 4px; padding: 8px 14px; font-size: 18px;\" href=\"\/diagnostics\/rna-panel-solution\/\" rel=\" noopener\">Find out more<\/a><\/span><\/p>\n<p>&nbsp;<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article id=\"item2\" class=\"c-accordion__item u-c-mid-grey accordion-2\">\n\t\t\t\t\t\t        <h4 class=\"c-accordion__title u-bg-white u-c-mid-grey js-accordionTarget-one\">Total RNA-Sequencing<\/h4>\n\t\t\t\t\t\t        <div class=\"c-accordion__content u-bg-white\">\n\t\t\t\t\t\t\t\t\t<div class=\"o-grid\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if image is there then allow content to sit with it -->\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if not then content goes full width -->\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"s-cms\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p><strong><span style=\"color: #7030a0;\">Total RNA-Sequencing<\/span><\/strong><\/p>\n<p><strong>The Platform<\/strong>: Total RNA-Seq is a ribosomal depletion approach for <strong>sequencing of both coding and non-coding regions<\/strong>.\u00a0 A total assessment specifically suitable for including an evaluation of non-coding regions in either <strong>fresh frozen (FF) or FFPE samples<\/strong>. Also includes in-built globin depletion for analysis of whole blood samples.<\/p>\n<p><strong><span style=\"color: #7030a0;\">Features &amp; Benefits:<\/span><\/strong><\/p>\n<ul>\n<li>Complete workflow with <strong>efficient ribosomal RNA (rRNA) depletion<\/strong> steps in-built<\/li>\n<li><strong>Lower duplication rates<\/strong> observed in samples resulting in increased sequencing success<\/li>\n<li>Additional downstream applications by targeting non-coding RNA<\/li>\n<\/ul>\n<div class=\"c-diag-table-wrap\">\n<table>\n<tbody>\n<tr>\n<th style=\"background-color: #7030a0;\">Metric<\/th>\n<th style=\"background-color: #7030a0;\">Total RNA-Seq Solution<\/th>\n<\/tr>\n<tr>\n<td>Chemistry<\/td>\n<td>Roche KAPA HyperPrep Kit with RiboErase (HMR)<\/td>\n<\/tr>\n<tr>\n<td>Tissue Type<\/td>\n<td>FF or FFPE (compatible with other sample types on request)<\/td>\n<\/tr>\n<tr>\n<td>Recommended Tissue Requirements<\/td>\n<td>\n<p>For FFPE, tissue should be macrodissected<br \/>\n10 x 5 \u00b5m FFPE sections with a tissue area &gt;1cm<sup>2<\/sup> and high tumour content &gt;10% viable cells<br \/>\nSpecific guidelines will be provided on a per-project basis<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>Recommended RNA Input<\/td>\n<td>Recommended Minimum 100 ng<\/td>\n<\/tr>\n<tr>\n<td>Standard Sequencing Specification<\/td>\n<td>\n<p>50M PE reads (100M Total Reads) for all applications<br \/>\nOther Sequencing specifications available on request<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>Deliverables<\/td>\n<td>FASTQ, FPKM Expression Matrix, Count Matrix and QC Report as standard.\u00a0 BAM files on request<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h6><strong>NOTE:<\/strong> Optimal sample number \u226524 samples<\/h6>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article id=\"item3\" class=\"c-accordion__item u-c-mid-grey accordion-3\">\n\t\t\t\t\t\t        <h4 class=\"c-accordion__title u-bg-white u-c-mid-grey js-accordionTarget-one\">mRNA Stranded Sequencing<\/h4>\n\t\t\t\t\t\t        <div class=\"c-accordion__content u-bg-white\">\n\t\t\t\t\t\t\t\t\t<div class=\"o-grid\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if image is there then allow content to sit with it -->\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if not then content goes full width -->\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"s-cms\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p><strong><span style=\"color: #7030a0;\">mRNA Stranded Sequencing<\/span><\/strong><\/p>\n<p><strong>The Platform<\/strong>: mRNA Stranded Sequencing is a polyA stranded capture approach for <strong>transcriptome sequencing including antisense analysis<\/strong> of good quality <strong>FF samples only<\/strong>.<\/p>\n<p><strong><span style=\"color: #7030a0;\">Features &amp; Benefits:<\/span><\/strong><\/p>\n<ul>\n<li>Captures a <strong>complete overview of the coding transcriptome with strand information<\/strong><\/li>\n<li>A <strong>broad dynamic range<\/strong> to enable accurate gene expression changes in good quality samples<\/li>\n<li>Provides an understanding of both <strong>known and novel RNA fusions<\/strong> in FF samples<\/li>\n<\/ul>\n<div class=\"c-diag-table-wrap\">\n<table>\n<tbody>\n<tr>\n<th style=\"background-color: #7030a0;\">Metric<\/th>\n<th style=\"background-color: #7030a0;\">mRNA Stranded Solution<\/th>\n<\/tr>\n<tr>\n<td>Chemistry<\/td>\n<td>Illumina TruSeq\u2122 Stranded mRNA<\/td>\n<\/tr>\n<tr>\n<td>Tissue Type<\/td>\n<td>FF only<\/td>\n<\/tr>\n<tr>\n<td>Recommended Tissue Requirements<\/td>\n<td>\n<p>Specific tissue guidelines will be provided on a per-project basis<\/p>\n<\/td>\n<\/tr>\n<tr>\n<td>Recommended RNA Input<\/td>\n<td>Recommended Minimum 100 ng<\/td>\n<\/tr>\n<tr>\n<td>Standard Sequencing Specification<\/td>\n<td>30M SE reads (30M Total Reads)<\/td>\n<\/tr>\n<tr>\n<td>Deliverables<\/td>\n<td>FASTQ, FPKM Expression Matrix, Count Matrix and QC Report as standard.\u00a0 BAM files on request.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h6><strong>NOTE:<\/strong> Optimal sample number \u226524 samples<\/h6>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<\/div> <!-- \/c-tabs -->\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div> <!-- \/o-grid -->\n\t<\/div> <!-- \/o-wrapper -->\n<\/section>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-size:26px\">Almac Additional Benefits for RNA Sequencing Solutions<\/h2>\n\n\n\n<p>Flexible Extraction Protocols: Almac offer both high quality <strong>single RNA extractions and a dual RNA\/DNA extraction protocol<\/strong> for our RNA-Sequencing solutions. Dual extraction facilitates simultaneous generation of RNA-Seq data and <a href=\"\/diagnostics\/dna-sequencing-solutions\/\"><strong style=\"color:#7030a0;\">DNA-Seq<\/strong><\/a> data from a single sample, <strong>conserving valuable sample material<\/strong>.<\/p>\n\n\n\n<p><strong>Customisable Analysis &amp; Reporting:<\/strong> Data analysis and reporting is performed using the latest DRAGEN suite of secondary analysis tools and\/or <strong>Almac customised<\/strong>&nbsp;<strong><a href=\"\/diagnostics\/supporting-services\/bioinformatics-biostatistics-excellence\/\"> bioinformatics<\/a>&nbsp;<\/strong><strong>pipelines<\/strong> hosted on the Illumina Connected Analytics (ICA) platform. ICA is a <strong>cloud-based NGS solution<\/strong> which enables full integration with Illumina sequencing instruments, whilst ensuring scalability and security of project data. A significant benefit of utilising ICA within this offering is the <strong>flexibility of workflow optimisation<\/strong> and the <strong>ability to customise bespoke pipelines<\/strong>.\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignright size-large\"><a href=\"https:\/\/www.almacgroup.com\/diagnostics\/claratreport\/\"><img decoding=\"async\" width=\"192\" height=\"135\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/claraT-logo-1.png\" alt=\"\" class=\"wp-image-1262 lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 192px; --smush-placeholder-aspect-ratio: 192\/135;\" \/><noscript><img decoding=\"async\" width=\"192\" height=\"135\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/claraT-logo-1.png\" alt=\"\" class=\"wp-image-1262\"\/><\/noscript><\/a><\/figure><\/div>\n\n\n<p>clara<sup>T<\/sup> \u2013 Unique gene expression report: <a href=\"\/diagnostics\/claratreport\/\">clara<sup>T<\/sup><\/a> classifies <strong>multiple publicly available gene expression signatures<\/strong> and <strong>single gene targets<\/strong> linked to <strong>multiple key biologies<\/strong>, alongside Almac\u2019s own proprietary assays, according to the well-established 10 <strong>Hallmarks of Cancer<\/strong>. The clara<sup>T<\/sup> report is a pan-cancer solution generated from raw gene expression data, utilising Almac\u2019s RNA-Sequencing Services.&nbsp;<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"single-cell\">Single Cell RNA-Sequencing Solutions<\/h2>\n\n\n\n<p>Almac offer Single Cell Next Generation Sequencing (NGS) solutions for biomarker discovery. Our Service uses the 10x Genomics Chromium X platform and 10x Genomics chemistries to generate RNA-seq data at the cellular level from cell suspension stored in either Cryo-preservative or cell suspension treated with Formaldehyde.<\/p>\n\n\n\n<p>The service includes a scalable bioinformatic pipeline underpinned by 10x Genomics Cell Ranger software, enabling comprehensive QC and single cell gene expression estimation.&nbsp;<\/p>\n\n\n\n<p>Optional custom bioinformatics solutions are also offered such as cell type identification, differential expression analysis between cell types and pathway analysis.<\/p>\n\n\n\t<div class=\"\">\n\t\t<div class=\"o-wrapper\">\n\t\t\t<div class=\"o-grid\">\n\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t\t<div class=\"s-cms\">\n\t\t\t\t\t\t<p><svg style=\"max-width: 690px;\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" viewBox=\"0 0 650 368\">\n  <image width=\"650\" height=\"368\" xlink:href=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2024\/12\/80269-ALMAC-DS-Single-Cell-RNA-Seq-Image-DESKTOP-620x380-FINAL-10x-Genomics-_Updated.jpg\"><\/image> <a xlink:href=\"https:\/\/www.almacgroup.com\/diagnostics\/single-cell-3-rna-sequencing-service\/\">\n    <rect x=\"238\" y=\"64\" fill=\"#fff\" opacity=\"0\" width=\"193\" height=\"100\"><\/rect>\n  <\/a><a xlink:href=\"https:\/\/www.almacgroup.com\/diagnostics\/fixed-single-cell-rna-sequencing-service\/\">\n    <rect x=\"241\" y=\"205\" fill=\"#fff\" opacity=\"0\" width=\"194\" height=\"100\"><\/rect>\n  <\/a>\n<\/svg><\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\n\t\n\n\n\n<p><strong>To find out more information on each Almac solution, click the appropriate drop-down below:<\/strong><\/p>\n\n\n<!-- Accordions -->\n<section class=\"u-bg-white u-p-y4 t-theme-component-overwrite\" id=\"accordionBlock\">\n\t<div class=\"o-wrapper\">\n\t\t<div class=\"o-grid o-grid--center\">\n\t\t\t<div class=\"o-grid__item u-width-full u-align-center u-align-left@m\">\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t<div class=\"u-m-t2\">\n\t\t\t\t\t<div class=\"c-accordion js-accordion\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article id=\"item1\" class=\"c-accordion__item u-c-mid-grey accordion-1\">\n\t\t\t\t\t\t        <h4 class=\"c-accordion__title u-bg-white u-c-mid-grey js-accordionTarget-one\">Almac Single cell 3\u2019 RNA Sequencing Service<\/h4>\n\t\t\t\t\t\t        <div class=\"c-accordion__content u-bg-white\">\n\t\t\t\t\t\t\t\t\t<div class=\"o-grid\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if image is there then allow content to sit with it -->\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if not then content goes full width -->\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"s-cms\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p><span style=\"color: #7030a0;\"><strong>Almac <\/strong><strong>Single cell 3\u2019 RNA Sequencing Service<\/strong><\/span><\/p>\n<p>A Next Generation Sequencing (NGS) solution which uses the 10x Genomics Chromium X platform and Next GEM Single Cell 3\u2019 workflow to generate RNA-seq data at the cellular level from cell suspension stored in Cryo-preservative. The service includes a scalable bioinformatic pipeline underpinned by 10x Genomics Cell Ranger software enabling comprehensive QC and single cell gene expression estimation.\u00a0 Optional custom bioinformatics solutions are also offered such as cell type identification, differential expression analysis between cell types and pathway analysis.<\/p>\n<p><strong><span style=\"color: #7030a0;\">Features &amp; Benefits:<\/span> <\/strong><\/p>\n<ul>\n<li><strong>Raw Sequence data <\/strong>delivered in FASTQ format, compatible with most bioinformatics pipelines for processing and interpreting single cell RNA Seq data.<\/li>\n<li><strong>Interactive QC report<\/strong> enables rapid and comprehensive assessment of sequencing, mapping, and cell metrics.<\/li>\n<li><strong>Optional bioinformatics services <\/strong>including fully customised downstream analysis and reporting.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<table style=\"height: 627px;\" width=\"703\">\n<tbody>\n<tr>\n<th style=\"background-color: #7030a0;\"><span style=\"color: #ffffff;\">Metric<\/span><\/th>\n<th style=\"background-color: #7030a0;\"><span style=\"color: #ffffff;\">Single cell 3\u2019 RNA Sequencing Service<\/span><\/th>\n<\/tr>\n<tr>\n<td>Chemistry<\/td>\n<td>10x Genomics Chromium Next GEM Single Cell 3\u2019 v3.1 Dual index<\/td>\n<\/tr>\n<tr>\n<td>Specimen Type<\/td>\n<td>Cell suspended in cryopreservative<\/td>\n<\/tr>\n<tr>\n<td>Input Material Requirements<\/td>\n<td>500 to 10,000 cells*<\/p>\n<p>*Depending on cell type and analysis required<\/td>\n<\/tr>\n<tr>\n<td>Coverage<\/td>\n<td>\u2265 20,000 reads per cell*<\/p>\n<p>*Tailored depending on analysis requirement<\/td>\n<\/tr>\n<tr>\n<td>Read Length<\/td>\n<td>90bp<\/td>\n<\/tr>\n<tr>\n<td>Deliverables<\/td>\n<td>FASTQ files (BAM files also available on request)<\/p>\n<p>Excel compatible QC report and interactive QC web summary report.<\/p>\n<p>Secondary analysis on 10x Genomics Cell Ranger Software<\/p>\n<p>Optional custom downstream bioinformatics analysis available at additional cost depending on requirements.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: 'trebuchet ms', geneva; font-weight: bold; color: #ffffff !important;\"><a style=\"color: #ffffff !important; background: #7030a0; text-decoration: none; border: 2px solid #7030a0; border-radius: 4px; padding: 8px 14px; font-size: 18px;\" href=\"\/diagnostics\/single-cell-3-rna-sequencing-service\/\" rel=\" noopener\">Find out more<\/a><\/span><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<article id=\"item2\" class=\"c-accordion__item u-c-mid-grey accordion-2\">\n\t\t\t\t\t\t        <h4 class=\"c-accordion__title u-bg-white u-c-mid-grey js-accordionTarget-one\">Almac Fixed Single Cell RNA Sequencing Service<\/h4>\n\t\t\t\t\t\t        <div class=\"c-accordion__content u-bg-white\">\n\t\t\t\t\t\t\t\t\t<div class=\"o-grid\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if image is there then allow content to sit with it -->\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- if not then content goes full width -->\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"o-grid__item u-width-full\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"s-cms\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t<p><span style=\"color: #7030a0;\"><strong>Almac Fixed Single Cell RNA Sequencing Service<\/strong><\/span><\/p>\n<p>A Next Generation Sequencing (NGS) solution which uses the 10x Genomics Chromium X platform and fixed single cell RNA-Seq workflow to generate RNA-seq data at the cellular level from cell suspension treated with Formaldehyde. The service includes a scalable bioinformatic pipeline underpinned by 10x Genomics Cell Ranger software enabling comprehensive QC and single cell gene expression estimation.\u00a0 Optional custom bioinformatics solutions are also offered such as cell type identification, differential expression analysis between cell types and pathway analysis.<\/p>\n<p><strong><span style=\"color: #7030a0;\">Features &amp; Benefits:<\/span> <\/strong><\/p>\n<ul>\n<li><strong>Raw Sequence data<\/strong> delivered in FASTQ format, compatible with most bioinformatics pipelines for processing and interpreting single cell RNA Seq data.<\/li>\n<li><strong>Interactive QC report<\/strong> enables rapid and comprehensive assessment of sequencing, mapping, and cell metrics.<\/li>\n<li><strong>Optional bioinformatics services<\/strong> including fully customised downstream analysis and reporting.<\/li>\n<\/ul>\n<table width=\"740\">\n<tbody>\n<tr>\n<th style=\"background-color: #7030a0;\"><span style=\"color: #ffffff;\">Metric<\/span><\/th>\n<th style=\"background-color: #7030a0;\"><span style=\"color: #ffffff;\">Single Cell RNA Seq Solution<\/span><\/th>\n<\/tr>\n<tr>\n<td width=\"226\">Chemistry<\/td>\n<td width=\"514\">Chromium Fixed RNA Profiling Reagents Kit with Dual index<\/td>\n<\/tr>\n<tr>\n<td width=\"226\">Specimen Type<\/td>\n<td width=\"514\">Cell suspended in cryopreservative<\/p>\n<p>Or cell fixed with Formaldehyde (10x Genomics protocol \u2013 CG000478)<\/td>\n<\/tr>\n<tr>\n<td width=\"226\">Input Material<\/p>\n<p>Requirements<\/td>\n<td width=\"514\">500 to 10,000 cells*<\/p>\n<p>*Depending on cell type and analysis required<\/td>\n<\/tr>\n<tr>\n<td width=\"226\">Coverage<\/td>\n<td width=\"514\">\u2265 20,000 reads per cell*<\/p>\n<p>*Tailored depending on analysis requirement<\/td>\n<\/tr>\n<tr>\n<td width=\"226\">Read Length<\/td>\n<td width=\"514\">90bp<\/td>\n<\/tr>\n<tr>\n<td width=\"226\">Deliverables<\/td>\n<td width=\"514\">FASTQ files (BAM files also available on request)<\/p>\n<p>Excel compatible QC report and interactive QC web summary report.<\/p>\n<p>Secondary analysis on 10x Genomics Cell Ranger Software<\/p>\n<p>Optional custom downstream bioinformatics analysis available at additional cost depending on requirements.<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p style=\"text-align: center;\"><span style=\"font-family: 'trebuchet ms', geneva; font-weight: bold;\"><a style=\"color: #ffffff !important; background: #7030a0; text-decoration: none; border: 2px solid #7030a0; border-radius: 4px; padding: 8px 14px; font-size: 18px;\" href=\"\/diagnostics\/fixed-single-cell-rna-sequencing-service\/\" rel=\" noopener\">Find out more<\/a><\/span><\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/article>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<\/div> <!-- \/c-tabs -->\n\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t<\/div> <!-- \/o-grid -->\n\t<\/div> <!-- \/o-wrapper -->\n<\/section>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-size:26px\">RNA-Sequencing Resources<\/h2>\n\n\n\n<p>To view additional resources such as whitepapers, technical factsheets, webinars and other information, <strong><a href=\"#relatedResourcesScroll\" style=\"color:#7030a0;\">click here<\/a><\/strong>.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" style=\"font-size:25px\">Contact Us<\/h2>\n\n\n\n<p>Interested in partnering with Almac on your biomarker project using our RNA Sequencing Solutions?&nbsp;Get in touch below:<\/p>\n\n\n\n\n\n\n\n<div id=\"relatedResourcesScroll\"><\/div>\n\n\n\t<article class=\"o-grid o-grid--full\">\n\n\t\t<div class=\"o-grid__item u-width-full u-m-t6 u-m-t4@m u-m-b4\">\n\t\t\t<h2 class=\"u-normal u-a-center\">Related Resources<\/h2>\n\t\t<\/div>\n\n\t\t<div class=\"u-flex u-flex-justify-center u-flex-wrap u-width-full c-news-panels__slider js-news-panels\">\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/overcoming-the-challenges-of-taking-rna-biomarkers-into-clinical-trials\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/04\/clarat-exome-bg.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Webinar<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Overcoming the Challenges of Taking RNA Biomarkers into Clinical Trials<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2025\/06\/Almac-Dx-RNA-Exome-Factsheet-Updated-June-2025.pdf\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Technical Sheet<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">RNA Exome Technical Specification<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2025\/06\/Almac-Dx-RNA-Exome-Whitepaper-Updated-June-2025.pdf\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">White paper<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">RNA Exome Whitepaper<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/diagnostics\/claratreport\/rna-blog\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Almac Voice<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">RNA-Seq Blog<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/rochesequencingstore.com\/catalog\/kapa-rna-hyperprep-kit-with-riboerase-hmr\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Technical Sheet<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Total RNA-Seq Technical Specification<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.illumina.com\/products\/by-type\/sequencing-kits\/library-prep-kits\/truseq-stranded-mrna.html?langsel=\/us\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Technical Sheet<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">mRNA Stranded Technical Specification<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/diagnostics\/claratreport\/press-release\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Article<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">claraT Press Release<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\n\n<!-- <article id=\"related\">\n\t<div class=\"o-grid\">\n\t\t\t\t<div class=\"o-grid__item u-width-full u-a-center\">\n\t\t\t\t\t\t\t<h3 class=\"u-normal u-m-b4\">Related Resources<\/h3>\n\t\t\t\t\t<\/div>\n\t\n\t\t<div class=\"u-flex u-flex-justify-center u-flex-wrap u-width-full c-resources__slider js-resources-panels\">\n\t\t\t\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/diagnostics\/diagnostic-resource\/overcoming-the-challenges-of-taking-rna-biomarkers-into-clinical-trials\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/04\/clarat-exome-bg.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Webinar<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Overcoming the Challenges of Taking RNA Biomarkers into Clinical Trials<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2025\/06\/Almac-Dx-RNA-Exome-Factsheet-Updated-June-2025.pdf\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Technical Sheet<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">RNA Exome Technical Specification<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2025\/06\/Almac-Dx-RNA-Exome-Whitepaper-Updated-June-2025.pdf\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">White paper<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">RNA Exome Whitepaper<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"\/diagnostics\/claratreport\/rna-blog\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Almac Voice<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">RNA-Seq Blog<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/rochesequencingstore.com\/catalog\/kapa-rna-hyperprep-kit-with-riboerase-hmr\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Technical Sheet<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Total RNA-Seq Technical Specification<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.illumina.com\/products\/by-type\/sequencing-kits\/library-prep-kits\/truseq-stranded-mrna.html?langsel=\/us\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Technical Sheet<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">mRNA Stranded Technical Specification<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-1\/3 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"\/diagnostics\/claratreport\/press-release\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Almac-Diagnostics-RNA-panel-solution-1.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Article<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">claraT Press Release<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/article> -->\n\n\n\n<style>\n.s-cms.s-cms--diagnostics p a {\n  color: #7030a0;\n}\n.dx-bio .c-careers__accordions .c-accordion__item:after {\n  content: '';\n}\n.c-table__bg table td {\n  background-color: white;\n  color: #798085;\n  border: 2px solid #798085;\n}\n.c-diag-table-wrap th {\n  border: 2px solid #798085;\n}\n<\/style>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Background Information Almac Diagnostic Services has a proven ability to discover, develop and validate high quality, innovative RNA-based biomarkers with an extensive track record in establishing assays across key regulatory standards. We currently offer multiple Research Use Only (RUO) RNA-Sequencing solutions analysed using the Illumina NextSeq500, NextSeq550, NovaSeq6000 and NovaSeq X Plus sequencing platforms.&nbsp; All [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"template-page-wrapper.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1255","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>RNA-Sequencing Solutions - Diagnostic Services<\/title>\n<meta name=\"description\" content=\"Proven ability to discover, develop and validate high quality, innovative RNA-based biomarkers with an extensive track record in establishing assays across key regulatory standards.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/rna-sequencing-solutions\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RNA-Sequencing Solutions\" \/>\n<meta property=\"og:description\" content=\"Proven ability to discover, develop and validate high quality, innovative RNA-based biomarkers with an extensive track record in establishing assays across key regulatory standards.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/rna-sequencing-solutions\/\" \/>\n<meta property=\"og:site_name\" content=\"Diagnostic Services\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-11T09:34:15+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/rna-chart-hotspot-mobile.svg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/rna-sequencing-solutions\/\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/rna-sequencing-solutions\/\",\"name\":\"RNA-Sequencing Solutions - 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