{"id":3271,"date":"2021-12-06T12:29:55","date_gmt":"2021-12-06T12:29:55","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?page_id=3271"},"modified":"2025-02-25T15:57:45","modified_gmt":"2025-02-25T15:57:45","slug":"publications","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/diagnostics\/claratreport\/publications\/","title":{"rendered":"Publications, Posters &#038; Presentations"},"content":{"rendered":"<div class=\"wp-block-image\">\n<figure class=\"alignright size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"752\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-1024x752.jpg\" alt=\"\" class=\"wp-image-3423 lazyload\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/752;width:193px;height:141px\" data-srcset=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-1024x752.jpg 1024w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-300x220.jpg 300w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-768x564.jpg 768w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-1536x1128.jpg 1536w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-2048x1504.jpg 2048w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" \/><noscript><img decoding=\"async\" width=\"1024\" height=\"752\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-1024x752.jpg\" alt=\"\" class=\"wp-image-3423\" style=\"width:193px;height:141px\" srcset=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-1024x752.jpg 1024w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-300x220.jpg 300w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-768x564.jpg 768w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-1536x1128.jpg 1536w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/claraT-Strapline-TM-Logo-2048x1504.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><\/figure><\/div>\n\n\n<p>The Almac clara<sup>T <\/sup>Total mRNA report has been utilised by multiple cancer researchers to enable their gene expression biomarker analysis. The following are some of the Publications, Posters and Presentations in which the researchers used clara<sup>T <\/sup>across various cancer indications.<\/p>\n\n\n\n<p>Almac is delighted to collaborate with and support these research institutions and global biopharma companies to advance human health.<\/p>\n\n\n\n<p>We thank them for their kind permission to include their work here.<\/p>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr>\n\n\n\n<div style=\"height:27px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-color\" id=\"h-publications\" style=\"color:#68006f\">Publications<\/h2>\n\n\n\n<!-- Half image, half text -->\n<section class=\"u-bg-white t-theme-component-overwrite\" id=\"halfMediaTextBlock\">\n    <div class=\"c-half-media-text \">\n        <div class=\"o-wrapper\">\n                                                        <article class=\"o-grid u-bg-white\">\n                            <div class=\"u-width-half u-width-7\/12@l u-width-full@m c-half-media__repeat-text none u-bg-white\">\n                                                                    <h2 class=\"u-m-b3\">University of Kansas Medical Center, USA<\/h2>\n                                                                <p><strong>ASCO JCO Precision Oncology<\/strong><\/p>\n<p><b><i>\u201cDual Prognostic Classi<\/i><\/b><b><i>fi<\/i><\/b><b><i>cation of Triple-Negative Breast <\/i><\/b><b><i>Cancer by DNA Damage Immune Response and Homologous <\/i><\/b><b><i>Recombination De<\/i><\/b><b><i>fi<\/i><\/b><b><i>ciency.\u201d <\/i><\/b><\/p>\n<p>Dr Shane R. Stecklein<\/p>\n<p>The Study, led by Dr Stecklein and colleagues demonstrated that the classification of DDIR assay and HRD could be used as a dual prognostic classifier in triple negative breast cancer (TNBC) patients.\u00a0 In summary, immune active (DDIR+\/HRD+) TNBCs exhibit the most favourable prognosis whereas immune depleted (DDIR-\/HRD-) show the worst prognosis. There is also an intermediate prognosis sub-group whereby being positive for only one biomer (i.e. either DDIR or HRD) showed inferior prognosis to immune active TNBCs but superior prognosis to immune depleted TMBCs. Taken together these results could help refine the categorisation of TNBC patients of breast cancer patients.<\/p>\n                                                                    <a class=\"c-btn c-btn-primary c-btn--diagnostics-blue u-m-t2 u-m-t0@m\" href=\"https:\/\/ascopubs.org\/doi\/10.1200\/PO.23.00197? \">View publication<\/a>\n                                                            <\/div>\n                            <div class=\"u-width-half u-width-5\/12@l u-width-full@m u-flex c-half-media__repeat-image\">\n                                                                    <img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2024\/02\/dx-university-of-kansas-publication.png\" alt=\"University of Kansas Medical Center, USA\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\"><noscript><img decoding=\"async\" class=\"\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2024\/02\/dx-university-of-kansas-publication.png\" alt=\"University of Kansas Medical Center, USA\"><\/noscript>\n                                                            <\/div>\n                        <\/article>\n                                                                            <article class=\"o-grid u-bg-white\">\n                            <div class=\"u-width-half u-width-7\/12@l u-width-full@m c-half-media__repeat-text none u-bg-white\">\n                                                                    <h2 class=\"u-m-b3\">Queens University Belfast<\/h2>\n                                                                <h4>British Journal of Cancer<\/h4>\n<p><strong><em>\u201cActivation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early.\u201d Dr. Stuart A. McIntosh<\/em><\/strong><\/p>\n<p>The Study led by Dr McIntosh and colleagues demonstrated that the DDIR assay could be used to identify a group of breast cancer patients which are more likely to benefit from a DNA damaging chemotherapy prior to surgery and have baseline activation of immune signalling.\u00a0 Furthermore, the team used a combination of transcriptome profiling, <em>de novo<\/em> discovery and the clara<sup>T<\/sup> report to demonstrate that patients with low baseline immune signalling or \u201ccold\u201d tumours are immune primed the through the use of this chemotherapy. Taken together these results could help refine the treatment of breast cancer patients and lead to better therapeutic outcomes.<\/p>\n                                                                    <a class=\"c-btn c-btn-primary c-btn--diagnostics-blue u-m-t2 u-m-t0@m\" href=\"https:\/\/www.nature.com\/articles\/s41416-021-01599-0\">View publication<\/a>\n                                                            <\/div>\n                            <div class=\"u-width-half u-width-5\/12@l u-width-full@m u-flex c-half-media__repeat-image\">\n                                                                    <img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/QUB-image.jpg\" alt=\"Queens University Belfast\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\"><noscript><img decoding=\"async\" class=\"\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/QUB-image.jpg\" alt=\"Queens University Belfast\"><\/noscript>\n                                                            <\/div>\n                        <\/article>\n                                                                            <article class=\"o-grid u-bg-white\">\n                            <div class=\"u-width-half u-width-7\/12@l u-width-full@m c-half-media__repeat-text none u-bg-white\">\n                                                                    <h2 class=\"u-m-b3\">University of Arkansas for Medical Sciences<\/h2>\n                                                                <h4>MDPI Cancers<\/h4>\n<p><strong><em>\u201cGenomic and Transcriptomic Profiling of Brain Metastases.\u201d Dr. Analiz Rodriguez<\/em><\/strong><\/p>\n<p>The Study led by Dr Rodriguez and colleagues utilised\u00a0 \u00a0clara<sup>T<\/sup> as a method to facilitate the molecular profiling of brain metastases. Together with other genomic and transcriptomic tools, clara<sup>T<\/sup> helped identify novel molecular subtypes and identified potential new drivers of brain cancer progression in parallel to novel drug candidates that may promote improved responses in these patients.<\/p>\n                                                                    <a class=\"c-btn c-btn-primary c-btn--diagnostics-blue u-m-t2 u-m-t0@m\" href=\"https:\/\/www.mdpi.com\/2072-6694\/13\/22\/5598\">View publication<\/a>\n                                                            <\/div>\n                            <div class=\"u-width-half u-width-5\/12@l u-width-full@m u-flex c-half-media__repeat-image\">\n                                                                    <img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/UA-image.jpg\" alt=\"University of Arkansas for Medical Sciences\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/600;\"><noscript><img decoding=\"async\" class=\"\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/UA-image.jpg\" alt=\"University of Arkansas for Medical Sciences\"><\/noscript>\n                                                            <\/div>\n                        <\/article>\n                                        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"solid\">\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-color\" id=\"h-posters\" style=\"color:#68006f\">Posters<\/h2>\n\n\n\n<!-- Half image, half text -->\n<section class=\"u-bg-white t-theme-component-overwrite\" id=\"halfMediaTextBlock\">\n    <div class=\"c-half-media-text \">\n        <div class=\"o-wrapper\">\n                                                        <article class=\"o-grid u-bg-white\">\n                            <div class=\"u-width-half u-width-7\/12@l u-width-full@m c-half-media__repeat-text none u-bg-white\">\n                                                                <h3>Queens University Belfast- ASCO Symposium 2020<\/h3>\n<p><em><strong>\u201cTranslational analysis of Esophageal Adenocarcinoma (EAC) patients treated with oxaliplatin\u00a0<\/strong><strong>and capecitabine (Xelox) +\/-the dual Erb B inhibitor AZD8931 in the DEBIOC study.\u201d<\/strong><\/em><\/p>\n<p><em>Dr Anita Lavery &amp; Dr Richard Turkington<\/em><\/p>\n                                                                    <a class=\"c-btn c-btn-primary c-btn--diagnostics-blue u-m-t2 u-m-t0@m\" href=\"https:\/\/almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/ASCO-poster-12.5.2020-Anita-Lavery-and-Richard-Turkington-QUB.pdf\">Download poster<\/a>\n                                                            <\/div>\n                            <div class=\"u-width-half u-width-5\/12@l u-width-full@m u-flex c-half-media__repeat-image\">\n                                                                    <img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/QUB-poster-cover-small.jpg\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/404;\"><noscript><img decoding=\"async\" class=\"\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/QUB-poster-cover-small.jpg\" alt=\"\"><\/noscript>\n                                                            <\/div>\n                        <\/article>\n                                                                            <article class=\"o-grid u-bg-white\">\n                            <div class=\"u-width-half u-width-7\/12@l u-width-full@m c-half-media__repeat-text none u-bg-white\">\n                                                                <h3>Almac Diagnostic Services<\/h3>\n<p><em><strong>\u00a0\u201cConsensus Gene Expression Analysis to Identify Key Hallmarks of Cancer in Malignant Melanoma.\u201d<\/strong><\/em><\/p>\n<p><em>Dr Jonathan Young<\/em><\/p>\n                                                                    <a class=\"c-btn c-btn-primary c-btn--diagnostics-blue u-m-t2 u-m-t0@m\" href=\"https:\/\/almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/Almac-Dx-Sanofi-Symposium-Poster-ClaraT-June-2021-FINAL.pdf\">Download poster<\/a>\n                                                            <\/div>\n                            <div class=\"u-width-half u-width-5\/12@l u-width-full@m u-flex c-half-media__repeat-image\">\n                                                                    <img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/Almac-dx-front-cover.jpg\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/404;\"><noscript><img decoding=\"async\" class=\"\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/Almac-dx-front-cover.jpg\" alt=\"\"><\/noscript>\n                                                            <\/div>\n                        <\/article>\n                                                                            <article class=\"o-grid u-bg-white\">\n                            <div class=\"u-width-half u-width-7\/12@l u-width-full@m c-half-media__repeat-text none u-bg-white\">\n                                                                <h3>Gilead \u2013 ASCO Gastrointestinal Cancers Symposium 2020<\/h3>\n<p><em>\u201c<strong>Identification of Cancer Hallmarks Associated with Benefit in Advanced Gastroesophageal Adenocarcinoma Patients Treated with Checkpoint Blockade.\u201d<\/strong><\/em><\/p>\n<p><em>Emon Elboudwarej<\/em><\/p>\n                                                                    <a class=\"c-btn c-btn-primary c-btn--diagnostics-blue u-m-t2 u-m-t0@m\" href=\"https:\/\/almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/Emon-CheckpointBlockade_ASCOGI-2020-FINAL.pdf\">Download poster<\/a>\n                                                            <\/div>\n                            <div class=\"u-width-half u-width-5\/12@l u-width-full@m u-flex c-half-media__repeat-image\">\n                                                                    <img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/gilead-cover.jpg\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/404;\"><noscript><img decoding=\"async\" class=\"\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/gilead-cover.jpg\" alt=\"\"><\/noscript>\n                                                            <\/div>\n                        <\/article>\n                                        <\/div>\n    <\/div>\n<\/section>\n\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<hr class=\"solid\">\n\n\n\n<div style=\"height:47px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading has-text-color\" id=\"h-presentations\" style=\"color:#68006f\">Presentations<\/h2>\n\n\n\n<!-- Half image, half text -->\n<section class=\"u-bg-white t-theme-component-overwrite\" id=\"halfMediaTextBlock\">\n    <div class=\"c-half-media-text \">\n        <div class=\"o-wrapper\">\n                                                        <article class=\"o-grid u-bg-white\">\n                            <div class=\"u-width-half u-width-7\/12@l u-width-full@m c-half-media__repeat-text none u-bg-white\">\n                                                                <h3>SWOG \u2013 San Antonio Breast Cancer Symposium (SABCS) 2020<\/h3>\n<p><strong>\u201cClassification of triple negative breast cancer (TBNC) by DNA damage immune response (DDIR) signature and homologous recombination deficiency (HRD) status: Analysis of SWOG S9313 adjuvant trial.\u201d<\/strong><\/p>\n<p>Shane Stecklein, University of Kansas<\/p>\n                                                                    <a class=\"c-btn c-btn-primary c-btn--diagnostics-blue u-m-t2 u-m-t0@m\" href=\"https:\/\/almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/SWOG-SABCS-2020_Final-Slides.pdf\">Download presentation<\/a>\n                                                            <\/div>\n                            <div class=\"u-width-half u-width-5\/12@l u-width-full@m u-flex c-half-media__repeat-image\">\n                                                                    <img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/SABCS-front-cover.jpg\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" style=\"--smush-placeholder-width: 600px; --smush-placeholder-aspect-ratio: 600\/404;\"><noscript><img decoding=\"async\" class=\"\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/12\/SABCS-front-cover.jpg\" alt=\"\"><\/noscript>\n                                                            <\/div>\n                        <\/article>\n                                        <\/div>\n    <\/div>\n<\/section>\n\n","protected":false},"excerpt":{"rendered":"<p>The Almac claraT Total mRNA report has been utilised by multiple cancer researchers to enable their gene expression biomarker analysis. The following are some of the Publications, Posters and Presentations in which the researchers used claraT across various cancer indications. Almac is delighted to collaborate with and support these research institutions and global biopharma companies [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":72,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-3271","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Publications, Posters &amp; Presentations - Diagnostic Services<\/title>\n<meta name=\"description\" content=\"Access publications, Posters and Presentations in which cancer researchers used claraT across various cancer indications\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/claratreport\/publications\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publications, Posters &amp; 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