{"id":511,"date":"2020-02-28T16:41:00","date_gmt":"2020-02-28T16:41:00","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?page_id=511"},"modified":"2023-12-06T16:34:47","modified_gmt":"2023-12-06T16:34:47","slug":"pharmacodynamic-biomarker-testing","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/diagnostics\/clinical-trial-solutions\/pharmacodynamic-biomarker-testing\/","title":{"rendered":"Pharmacodynamic Biomarker Testing"},"content":{"rendered":"\n<h4 class=\"wp-block-heading has-large-font-size\">Almac PD Biomarker Testing Service<\/h4>\n\n\n\n<p>Almac Diagnostic Services can help Biopharma clients<strong> validate reliable PD assays<\/strong> that can help provide invaluable guidance within their drug development programmes.<\/p>\n\n\n\n<p>Almac can develop and perform PD testing on <strong><a href=\"\/diagnostics\/supporting-services\/platforms-technologies\/\">multiple technology platforms<\/a><\/strong> across <strong>multiple sample types<\/strong> for <strong>qPCR<\/strong> and Next Generation Sequencing <strong>(NGS)<\/strong> from our global CLIA and CAP-accredited<strong> <a href=\"\/diagnostics\/supporting-services\/global-laboratories\/\">labs<\/a><\/strong>.<\/p>\n\n\n\n<p>Clients may wish to provide previous existing data from matched pre- and post-treatment samples and our <a href=\"\/diagnostics\/supporting-services\/data-sciences\/\"><strong>Data Sciences<\/strong><\/a> team can provide <strong>solutions for selection of an appropriate PD biomarker<\/strong>, alternatively, clients may already have a <strong>pre-defined PD biomarker<\/strong> they would like Almac to test for them.<\/p>\n\n\n\n<p>Almac Diagnostic Services has <strong>extensive experience in PD Biomarker Testing<\/strong>. As part of our overall <strong><a href=\"\/diagnostics\/clinical-trial-solutions\/sample-management\/\">Clinical Trial Solutions<\/a><\/strong> we can deliver for clients either:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>An independent PD Biomarker measurement<\/strong><\/li>\n\n\n\n<li><strong>A PD Biomarker measurement integrated with a predictive clinical trial assay (CTA)<\/strong><\/li>\n<\/ul>\n\n\n\n<p>If a client chooses Almac for combined delivery of both the predictive and PD biomarker within their clinical trial programme Almac can deliver <strong>significant efficiencies<\/strong> in terms of time and cost savings.<\/p>\n\n\n\n<p>Specific efficiencies can be gained through centralised <strong><a href=\"\/diagnostics\/clinical-trial-solutions\/sample-management\/\">sample management<\/a>,<\/strong> <strong><a href=\"\/diagnostics\/supporting-services\/pathology\/\">pathology review<\/a> &amp; <a href=\"\/diagnostics\/supporting-services\/global-laboratories\/\">nucleic acid extraction<\/a><\/strong>.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-medium-font-size\"><strong>Benefits<\/strong><\/h4>\n\n\n\n<p><strong>Streamlined Process &amp; Combined Efficiencies<\/strong><\/p>\n\n\n\n<p>Utilising Almac as a centralised provider, rather than outsourcing PD biomarker work and CTA development work to multiple CRO vendors, creates a much more streamlined process. This also results in logistics efficiencies and reduced risk for client\u2019s drug development programmes.<\/p>\n\n\n\n<p><strong>Cost &amp; Time Savings<\/strong><\/p>\n\n\n\n<p>This can directly translate into savings for clients with a \u2018same sample, same lab\u2019 approach of combined PD biomarker and CTA testing saving time and reducing cost with one provider.<\/p>\n\n\n\n<p><strong>Better Informed Decision Making<\/strong><\/p>\n\n\n\n<p>Combining drug development data with biomarker efficacy data from Almac focused PD biomarker measurements provides critical information to help inform key drug development milestone decisions much earlier on in the process.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"u-bg- t-theme-component-overwrite\" id=\"halfMediaHalfTextNewBlock\">\n    <div class=\"o-wrapper\">\n        <div class=\"o-grid\">\n            <div class=\"o-grid__item u-width-full\">\n                \n\n                    <!--If media is image, show it left, content right -->\n                    \n                        <div class=\"u-flex u-width-full u-m-y6 u-flex-direction-column@m\">\n                            <div class=\"u-width-half u-width-full@m\">\n                                <img decoding=\"async\" class=\"u-width-full u-height-100pc lazyload\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/11\/claraT-thumb-e1635253806396.png\" alt=\"\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 489px; --smush-placeholder-aspect-ratio: 489\/349;\" \/><noscript><img decoding=\"async\" class=\"u-width-full u-height-100pc\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2021\/11\/claraT-thumb-e1635253806396.png\" alt=\"\"\/><\/noscript>\n                            <\/div>\n                            <div class=\"u-width-half u-width-full@m u-bg- u-p6 u-p2@l\">\n                                <div class=\"u-middle u-middle-none@m\">\n                                                                        <div class=\"u-c-\"><p><strong>Almac\u2019s unique gene expression report clara<sup>T<\/sup>also allows cancer researchers to discover novel insights within pharmacodynamic (PD) biomarker discovery<\/strong>. By allowing multiple biologies to be evaluated in parallel, the\u00a0<strong><a href=\"\/diagnostics\/claratreport\/\">claraT Total mRNA Report<\/a><\/strong>\u00a0supports the identification of pre and post expression changes within novel pathways and biologies that may play a role in response to therapeutic targets.<\/p>\n<\/div>\n                                                                    <\/div>\n                            <\/div>\n                        <\/div>\n\n\n                     <!--If media is video, show it left, content right -->\n                    \n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-medium-font-size\" id=\"h-example-of-almac-pd-biomarker-process-integrated-with-a-clinical-trial-assay\"><strong>Example of Almac PD Biomarker Process integrated with a Clinical Trial Assay<\/strong><\/h4>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><img decoding=\"async\" width=\"1024\" height=\"809\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1.png\" alt=\"\" class=\"wp-image-2091 lazyload\" data-srcset=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1.png 1024w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1-300x237.png 300w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1-768x607.png 768w\" data-sizes=\"(max-width: 1024px) 100vw, 1024px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 1024px; --smush-placeholder-aspect-ratio: 1024\/809;\" \/><noscript><img decoding=\"async\" width=\"1024\" height=\"809\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1.png\" alt=\"\" class=\"wp-image-2091\" srcset=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1.png 1024w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1-300x237.png 300w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1-768x607.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/noscript><\/figure><\/div>\n\n\n<p>PD Biomarker and predictive CTA combined activity in the same Almac laboratory providing streamlined efficiencies for clients.<\/p>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h4 class=\"wp-block-heading has-medium-font-size\" id=\"h-contact-us\"><strong>Contact Us<\/strong><\/h4>\n\n\n\n<p>Interested in PD Biomarker testing in conjunction with predictive biomarker testing as part of your Clinical Trial? Get in touch with Almac Diagnostic Services for a quote.<\/p>\n\n\n\n\n\n\n\n<style>\n.c-accordion__item .c-accordion__content { max-height:1000px; }\n.c-careers__accordions .c-accordion__item .c-accordion__content { opacity:1; }\n.c-accordion__title { cursor: auto !important; }\n.c-accordion__title:after { display: none !important; }\n<\/style>\n","protected":false},"excerpt":{"rendered":"<p>Almac PD Biomarker Testing Service Almac Diagnostic Services can help Biopharma clients validate reliable PD assays that can help provide invaluable guidance within their drug development programmes. Almac can develop and perform PD testing on multiple technology platforms across multiple sample types for qPCR and Next Generation Sequencing (NGS) from our global CLIA and CAP-accredited [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":8,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-511","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Pharmacodynamic Biomarker Testing - Diagnostic Services<\/title>\n<meta name=\"description\" content=\"Almac can help Biopharma clients validate reliable Pharmacodynamic (PD) assays that can help provide invaluable guidance within their drug development programmes.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/clinical-trial-solutions\/pharmacodynamic-biomarker-testing\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Pharmacodynamic Biomarker Testing\" \/>\n<meta property=\"og:description\" content=\"Almac can help Biopharma clients validate reliable Pharmacodynamic (PD) assays that can help provide invaluable guidance within their drug development programmes.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/clinical-trial-solutions\/pharmacodynamic-biomarker-testing\/\" \/>\n<meta property=\"og:site_name\" content=\"Diagnostic Services\" \/>\n<meta property=\"article:modified_time\" content=\"2023-12-06T16:34:47+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/06\/PD-Biomarkers-Flow-Diagram-002-ed-1024x809-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/clinical-trial-solutions\/pharmacodynamic-biomarker-testing\/\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/clinical-trial-solutions\/pharmacodynamic-biomarker-testing\/\",\"name\":\"Pharmacodynamic Biomarker Testing - 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