{"id":66,"date":"2020-01-22T10:25:15","date_gmt":"2020-01-22T10:25:15","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?page_id=66"},"modified":"2023-05-18T12:19:16","modified_gmt":"2023-05-18T11:19:16","slug":"emt","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/diagnostics\/portfolio-overview\/emt\/","title":{"rendered":"EMT"},"content":{"rendered":"\n<p>A molecular subgroup has been identified which is characterised by upregulation of Receptor Tyrosine Kinases (RTKs) and the MAPK pathway, leading to increased Epithelial to Mesenchymal Transition (EMT) and angiogenesis. The subgroup exists across multiple diseases and patients within it demonstrate poor prognosis across multiple cancers, including breast, lung, colon, renal, pancreatic, stomach, bladder, ovarian, melanoma and glioblastoma.<\/p>\n\n\n\n<p>A 15 gene signature has been developed to prospectively identify patients which fall into the EMT molecular subgroup from formalin-fixed paraffin-embedded (FFPE) tissue and can be used to select patients for:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>MAPK targeted therapies (for example: MEK, p38 inhibitors)<\/li>\n\n\n\n<li>EMT targeted therapies (for example: AXL inhibitors)<\/li>\n\n\n\n<li>RTK targeted therapies (for example: Tyrosine kinase inhibitors)<\/li>\n<\/ol>\n\n\n\n\n    <div class=\"u-flex u-flex-justify-start   u-m-t-auto \">\n                            <a class=\"c-btn c-btn-secondary c-btn--red\" href=\"\/diagnostics\/contact-us\/\">Contact Us<\/a>\n                    <\/div>\n\n\n\n<div class=\"u-flex u-block@m\">&nbsp;<\/div>\n<p>&nbsp;<\/p>\n<div class=\"u-flex u-block@m\">\n<div class=\"u-align-center u-p-a2 u-bg-light-grey u-m-r1 u-m-b1\" style=\"max-width: 400px;\">\n<p><a href=\"\/diagnostics\/claratreport\/\"><img decoding=\"async\" class=\"aligncenter wp-image-51373 lazyload\" data-src=\"\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/claraT-logo-1-1.png\" alt=\"\" width=\"154\" height=\"108\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 154px; --smush-placeholder-aspect-ratio: 154\/108;\"><noscript><img decoding=\"async\" class=\"aligncenter wp-image-51373 \" src=\"\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/claraT-logo-1-1.png\" alt=\"\" width=\"154\" height=\"108\"><\/noscript><\/a><\/p>\n<h4><a href=\"\/diagnostics\/claratreport\/\">Almac EMT Assay<\/a><\/h4>\n<\/div>\n<div class=\"u-align-center u-p-a2 u-bg-light-grey u-m-r1 u-m-b1\" style=\"max-width: 400px;\">\n<p><br>\n<img decoding=\"async\" class=\"aligncenter wp-image-51374 lazyload\" data-src=\"\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Untitled-2-1.png\" alt=\"\" width=\"394\" height=\"166\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 394px; --smush-placeholder-aspect-ratio: 394\/166;\"><noscript><img decoding=\"async\" class=\"aligncenter wp-image-51374 \" src=\"\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Untitled-2-1.png\" alt=\"\" width=\"394\" height=\"166\"><\/noscript><\/p>\n<\/div>\n<\/div>\n<div class=\"u-align-center u-p-a2 u-bg-light-grey u-m-r1 u-m-b1\" style=\"max-width: 625px;\">\n<p>Assessment of the Almac EMT Assay can be made through use of Almac Diagnostic Services unique gene expression report, <a href=\"\/diagnostics\/claratreport\/\">clara<sup>T<\/sup><\/a>.This provides visualisation of the EMT Assay scores as an easy-to-interpret graduated bar.<\/p>\n<\/div>\n\n\n\n<div style=\"height:56px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"o-wrapper\">\n\t<div class=\"o-grid\">\n\n\t\t<div class=\"o-grid__item u-width-full \">\n\t\t\t\t\t\t\t<h2 class=\"u-m-b4\">Related Resources<\/h2>\n\t\t\t\t\t<\/div>\n\n\t<\/div>\n            <div class=\"o-grid u-flex-align-stretch u-m-b3\">\n\n            \n                                            <article class=\"o-grid__item u-width-4\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x4 u-p-y3 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Poster<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">Development of a Pan-Cancer 15 Gene Expression Signature to Detect a Subgroup Driven by MAPK Signalling<\/h4>\n                        \n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/The-Almac-Diagnostics-Lung-Cancer-DSA\u2122-research-tool-offers-the-most-comprehensive-platform-available-for-the-study-of-Lung-Cancer..ppt\" target=\"\">Learn more<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                    <\/div>\n    <\/div>\n","protected":false},"excerpt":{"rendered":"<p>A molecular subgroup has been identified which is characterised by upregulation of Receptor Tyrosine Kinases (RTKs) and the MAPK pathway, leading to increased Epithelial to Mesenchymal Transition (EMT) and angiogenesis. The subgroup exists across multiple diseases and patients within it demonstrate poor prognosis across multiple cancers, including breast, lung, colon, renal, pancreatic, stomach, bladder, ovarian, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":51,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-66","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>EMT - Diagnostic Services<\/title>\n<meta name=\"description\" content=\"A molecular subgroup has been identified which is characterised by upregulation of Receptor Tyrosine Kinases (RTKs) and the MAPK pathway, leading to increased Epithelial to Mesenchymal Transition (EMT) and angiogenesis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/portfolio-overview\/emt\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"EMT\" \/>\n<meta property=\"og:description\" content=\"A molecular subgroup has been identified which is characterised by upregulation of Receptor Tyrosine Kinases (RTKs) and the MAPK pathway, leading to increased Epithelial to Mesenchymal Transition (EMT) and angiogenesis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/portfolio-overview\/emt\/\" \/>\n<meta property=\"og:site_name\" content=\"Diagnostic Services\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-18T11:19:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/11\/Almac_Logo-e1698941154737.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"100\" \/>\n\t<meta property=\"og:image:height\" content=\"52\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/portfolio-overview\/emt\/\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/portfolio-overview\/emt\/\",\"name\":\"EMT - 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