{"id":80,"date":"2020-01-22T10:30:37","date_gmt":"2020-01-22T10:30:37","guid":{"rendered":"https:\/\/www.almacgroup.com\/diagnostics\/?page_id=80"},"modified":"2025-02-25T15:47:51","modified_gmt":"2025-02-25T15:47:51","slug":"rna-blog","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/diagnostics\/claratreport\/rna-blog\/","title":{"rendered":"RNA Blog"},"content":{"rendered":"\n<h1 class=\"wp-block-heading\">The increasing uptake of RNA-Seq as the technology of choice in biomarker discovery<\/h1>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignleft size-large is-resized\"><a href=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2019\/01\/Nuala.png\"><img decoding=\"async\" data-src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Nuala-300x300-1.png\" alt=\"\" class=\"wp-image-1061 lazyload\" width=\"100\" height=\"100\" data-srcset=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Nuala-300x300-1.png 300w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Nuala-300x300-1-150x150.png 150w\" data-sizes=\"(max-width: 100px) 100vw, 100px\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 100px; --smush-placeholder-aspect-ratio: 100\/100;\" \/><noscript><img decoding=\"async\" src=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Nuala-300x300-1.png\" alt=\"\" class=\"wp-image-1061\" width=\"100\" height=\"100\" srcset=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Nuala-300x300-1.png 300w, https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Nuala-300x300-1-150x150.png 150w\" sizes=\"(max-width: 100px) 100vw, 100px\" \/><\/noscript><\/a><\/figure><\/div>\n\n\n\n<h4 class=\"wp-block-heading\">Dr Nuala McCabe<\/h4>\n\n\n\n<p><strong>Biomarker Research Manager, Almac Diagnostic Services<\/strong><\/p>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<article class=\"u-flex u-flex-align-flex-start u-flex-direction-column@m\">\n<div class=\"u-align-center u-p-a2 u-bg-light-grey u-m-r2 u-m-b1 u-m-t2 u-order-2@m u-width-full@m\">\n<p><a href=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2019\/02\/Almac-DX-Blog-Post-Rise-in-RNA-Biomarkers-Dr-Nuala-McCabe-FINAL-February-2019.pdf\"><img decoding=\"async\" class=\"aligncenter size-full lazyload\" data-src=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2019\/01\/Nuala.png\" alt=\"TP53 Clinical Trial Assay\" width=\"200\" height=\"273\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" style=\"--smush-placeholder-width: 200px; --smush-placeholder-aspect-ratio: 200\/273;\"><noscript><img decoding=\"async\" class=\"aligncenter size-full\" src=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2019\/01\/Nuala.png\" alt=\"TP53 Clinical Trial Assay\" width=\"200\" height=\"273\"><\/noscript><\/a><\/p>\n<p class=\"u-m-t2\"><a class=\"c-btn c-btn--clarat-purple\" title=\"Contact Us\" href=\"https:\/\/www.almacgroup.com\/wp-content\/uploads\/2019\/02\/Almac-DX-Blog-Post-Rise-in-RNA-Biomarkers-Dr-Nuala-McCabe-FINAL-February-2019.pdf\">Download the article<\/a><\/p>\n<\/div>\n<div class=\"u-order-1@m\" style=\"width: 100%; position: relative;\">\n<div class=\"c-video\"><iframe style=\"position: absolute; left: 0; top: 0; width: 100%; height: 100%;\" data-src=\"https:\/\/player.vimeo.com\/video\/329776484?autoplay=1;title=0&amp;byline=0&amp;portrait=0\" allowfullscreen=\"allowfullscreen\" frameborder=\"0\" align=\"right\" src=\"data:image\/gif;base64,R0lGODlhAQABAAAAACH5BAEKAAEALAAAAAABAAEAAAICTAEAOw==\" class=\"lazyload\" data-load-mode=\"1\"><span class=\"mce_SELRES_start\" data-mce-type=\"bookmark\" style=\"display: inline-block; width: 0px; overflow: hidden; line-height: 0;\">\ufeff<\/span><\/iframe><\/div>\n<\/div>\n<\/article>\n\n\n\n<h4 class=\"wp-block-heading\">Blog Excerpt<\/h4>\n\n\n\n<p><strong>RNA biomarkers \u2013 a largely untapped, but beneficial resource<\/strong><\/p>\n\n\n\n<p>Next generation sequencing (NGS) has evolved as a valuable tool for biomarker discovery and development. This new era of research into biomarker discovery has largely focused on DNA based biomarkers rather than RNA based biomarkers and is exemplified by the number of publications in the NGS field, mostly DNA related (Figure 1A). To date, RNA has been a relatively untapped resource for biomarker discovery. However, within the past 8-10 years, there has been a significant rise in the number of NGS publications featuring RNA-Sequencing (RNASeq) (Figure 1B). This change has been driven by the realisation that researchers cannot solely rely on DNA aberrations to understand tumour biology but also need other omics data such as RNA profiling to capture a more comprehensive view.<\/p>\n\n\n\n<p><strong>The evolution of RNA-Seq<\/strong><\/p>\n\n\n\n<p>Traditionally cDNA microarray technology has been the primary method of choice for gene expression profiling. However, with the continued advancement of NGS technology, RNA-Seq is rapidly emerging as the principal discovery tool. Unlike microarrays which are limited in their design to the detection of known transcripts, RNA-Seq has the potential to detect novel transcripts and structural variants such as alternative splicing events and gene fusions and can also identify allele-specific expression and disease-associated single nucleotide polymorphisms (SNP). Furthermore, RNA-Seq technology also avoids the hybridization&nbsp;based issues associated with microarrays and demonstrates a broader dynamic range (&gt;8,000 fold), with low background signals. For differential gene expression analysis, RNA-Seq demonstrates superior levels of accuracy in the quantification of highly expressed genes and sensitivity in lowly expressed genes when compared to microarrays.<\/p>\n\n\n\n<h6 class=\"wp-block-heading\">The information contained in this article is accurate, to the best of the author\u2019s knowledge, as of 1 February 2019.<\/h6>\n\n\n\n<h6 class=\"wp-block-heading\"><strong>clara<sup>T<\/sup><\/strong> TM is a trade mark of Almac. Other trade marks referenced are those of third parties. &nbsp;<\/h6>\n\n\n\n<div style=\"height:24px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\"><strong>To read the full blog either download the PDF above, or to read the entire Almac Voice Article Online <a href=\"https:\/\/www.almacgroup.com\/diagnostic-resource\/the-increasing-uptake-of-rna-seq-as-the-technology-of-choice-in-biomarker-discovery\/\">click here<\/a>.<\/strong><\/h5>\n","protected":false},"excerpt":{"rendered":"<p>The increasing uptake of RNA-Seq as the technology of choice in biomarker discovery Dr Nuala McCabe Biomarker Research Manager, Almac Diagnostic Services Download the article \ufeff Blog Excerpt RNA biomarkers \u2013 a largely untapped, but beneficial resource Next generation sequencing (NGS) has evolved as a valuable tool for biomarker discovery and development. This new era [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":72,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-80","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>RNA Blog - Diagnostic Services<\/title>\n<meta name=\"description\" content=\"Access an Almac blog discussing &#039;The increasing uptake of RNA-Seq as the technology of choice in biomarker discovery&#039;\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/diagnostics\/claratreport\/rna-blog\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RNA Blog\" \/>\n<meta property=\"og:description\" content=\"Access an Almac blog discussing &#039;The increasing uptake of RNA-Seq as the technology of choice in biomarker discovery&#039;\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/claratreport\/rna-blog\/\" \/>\n<meta property=\"og:site_name\" content=\"Diagnostic Services\" \/>\n<meta property=\"article:modified_time\" content=\"2025-02-25T15:47:51+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.almacgroup.com\/diagnostics\/wp-content\/uploads\/sites\/3\/2020\/03\/Nuala-300x300-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"300\" \/>\n\t<meta property=\"og:image:height\" content=\"300\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.almacgroup.com\/diagnostics\/claratreport\/rna-blog\/\",\"url\":\"https:\/\/www.almacgroup.com\/diagnostics\/claratreport\/rna-blog\/\",\"name\":\"RNA Blog - 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