Ubiquitin Specific Protease Platform

Target Class

Deubiquitinase (DUB) / Ubiquitin Specific Protease (USP)

Modality

Small molecule

Descriptor

Innovative USP/DUBs drug discovery platform

Status

The platform is now being exploited for a number of DUBs.  Small molecule inhibitors and fragments have been identified and subsequently validated.  These provide new exciting opportunities for Medicinal Chemistry.  De novo target identification and validation efforts are also an integral part of this discovery platform to ensure sustainability and the development of truly innovative therapeutics.

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