Deubiquitinase (DUB) / Ubiquitin Specific Protease (USP)
Innovative USP/DUBs drug discovery platform
The platform is now being exploited for a number of DUBs. Small molecule inhibitors and fragments have been identified and subsequently validated. These provide new exciting opportunities for Medicinal Chemistry. De novo target identification and validation efforts are also an integral part of this discovery platform to ensure sustainability and the development of truly innovative therapeutics.