{"id":1134,"date":"2020-10-14T16:45:47","date_gmt":"2020-10-14T15:45:47","guid":{"rendered":"https:\/\/www.almacgroup.com\/discovery\/?page_id=1134"},"modified":"2026-02-24T10:49:38","modified_gmt":"2026-02-24T10:49:38","slug":"articles-publications","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/discovery\/articles-publications\/","title":{"rendered":"Articles &#038; Publications"},"content":{"rendered":"<div class=\"o-wrapper\">\n\t<div class=\"o-grid\">\n\n\t\t<div class=\"o-grid__item u-width-full \">\n\t\t\t\t\t<\/div>\n\n\t<\/div>\n            <div class=\"o-grid u-flex-align-stretch u-m-b3\">\n\n            \n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Publication<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">Discovery and characterization of highly potent and selective allosteric USP7 inhibitors<br><br><\/h4>\n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\"><strong>Nature Chemical Biology volume 14, pages 118\u2013125(2018)<\/strong><br>\r\n\r\nGerald Gavory, Colin R O&#8217;Dowd, Matthew D Helm, Jakub Flasz, Elias Arkoudis, Anthony Dossang, Caroline Hughes, Eamon Cassidy, Keeva McClelland, Ewa Odrzywol, Natalie Page, Oliver Barker, Hugues Miel &#038; Timothy Harrison<\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"https:\/\/www.nature.com\/articles\/nchembio.2528\" target=\"_blank\">Read the article here<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Publication<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">Identification and characterisation of dual inhibitors of the USP25\/28 deubiquitinating enzyme subfamily<\/h4>\n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\"><strong>ACS Chem Biol, 2017, 12, 3113-3125<\/strong><br>\r\nJonathan D Wrigley, Gerald Gavory, Iain Simpso, Marian Preston 1 , Helen Plant, Jenna Bradle , Anne U Goeppert, Ewelina Rozycka, Gareth Davies, Jarrod Walsh, Andrea Valentine, Keeva McClelland, Krzysztofa Ewa Odrzywol , Jonathan Renshaw, Joanna Boros, Jonathan Tart, Lindsey Leach, Thorsten Nowak, Richard A Ward, Timothy Harrison, David M Andrews<\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acschembio.7b00334\" target=\"_blank\">Read the article here<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Publication<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors<br><br><\/h4>\n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\"><strong>ACS Med. Chem. Lett. 2018, 9, 3, 238\u2013243<\/strong><br>Colin R. O\u2019Dowd, Matthew D. Helm, J. S. Shane Rountree, Jakub T. Flasz, Elias Arkoudis, Hugues Miel, Peter R. Hewitt, Linda Jordan, Oliver Barker, Caroline Hughes, Ewelina Rozycka, Eamon Cassidy, Keeva McClelland, Ewa Odrzywol, Natalie Page, Stephanie Feutren-Burton, Scarlett Dvorkin, Gerald Gavory, Timothy Harrison <\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"https:\/\/pubs.acs.org\/doi\/abs\/10.1021\/acsmedchemlett.7b00512\" target=\"_blank\">Read the article here<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Article<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma<\/h4>\n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\"><strong>Sci Rep 14, 32121 (2024)<\/strong><br>Leanne Stevenson, Lauren Cairns, Xiaodun Li, Sriganesh Jammula, Harriet Taylor, Rosalie Douglas, Niamh McCabe, Gerald Gavory, Xavier Jacq, Rebecca C. Fitzgerald, Richard D. Kennedy, Timothy Harrison &#038; Richard C. Turkington <\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"https:\/\/www.nature.com\/articles\/s41598-024-83912-4\" target=\"_blank\">Read the article here<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Article<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF<\/h4>\n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\"><strong>Clin Transl Med. 2024; 14:e1648. <\/strong><br>Anamarija Jurisic, Pei-Ju Sung, Mark Wappett, Julien Daubriac, Ian T. Lobb, Wei-Wei Kung, Nyree Crawford, Natalie Page, Eamon Cassidy, Stephanie Feutren-Burton, J. S. Shane Rountree, Matthew D. Helm, Colin R. O&#8217;Dowd, Richard D. Kennedy, Gerald Gavory, Aaron N. Cranston, Daniel B. Longley, Xavier Jacq, Timothy Harrison<\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/ctm2.1648\" target=\"_blank\">Read the article here<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Article<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development<\/h4>\n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\"><strong>Sci Rep 12, 15715 (2022).<\/strong><br>Natalie Page, Mark Wappett, Colin R. O\u2019Dowd, Martin O\u2019Rourke, Gerald Gavory, Lixin Zhang, J. S. Shane Rountree, Linda Jordan, Oliver Barker, Hayley Gibson, Caroline Boyd, Stephanie Feutren-Burton, Estelle McLean, Graham Trevitt &#038; Timothy Harrison <\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"\" target=\"\">Read the article here<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Article<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours<\/h4>\n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\"><strong>Br J Cancer 127, 92\u2013101 (2022)<\/strong><br>Aya El Helali, Ruth Plummer, Gordon C. Jayson, Vicky M. Coyle, Yvette Drew, Nerissa Mescallado, Noor Harris, Andrew R. Clamp, Janine McCann, Helen Swaisland, Richard D. Kennedy, Aaron N. Cranston &#038; Richard H. Wilson <\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"https:\/\/www.nature.com\/articles\/s41416-022-01780-z\" target=\"\">Read the article here<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                                            <article class=\"o-grid__item u-width-3\/12 u-width-4\/12@l u-width-6\/12@m u-width-full@s u-flex u-m-b3 u-a-full\">\n                    <div class=\"c-related-resources__panel u-flex u-flex-direction-column u-flex-align-flex-start u-p-x2 u-p-y2 u-m-b2\">\n                \n                        \n                                                    <p class=\"c-resource__category\">Article<\/p>\n                        \n                                                    <h4 class=\"u-m-t2\">SynLeGG: analysis and visualization of multiomics data for discovery of cancer \u2018Achilles Heels\u2019 and gene function relationships<\/h4>\n                        \n                                                    <p class=\"u-m-y2 u-text-small ie-block-height\"><strong>Nucleic Acids Research, Volume 49, Issue W1, 2 July 2021, Pages W613\u2013W618<\/strong><br>Mark Wappett , Adam Harris , Alexander L R Lubbock , Ian Lobb , Simon McDade , Ian M Overton<\/p>\n                        \n                                                                                                                        <a class=\"u-m-t-auto c-btn c-btn-secondary c-btn--red\" href=\"https:\/\/academic.oup.com\/nar\/article\/49\/W1\/W613\/6275664\" target=\"\">Read the article here<\/a>\n                                                                                                        <\/div> <!-- \/c-related-resoucres__panel -->\n                    <\/article>\n                    <\/div>\n    <\/div>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1134","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Articles &amp; 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