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Diagnostic Services
Your Clinical Trial Diagnostic Partner
API Services & Chemical Development
Providing services for all stages of drug development for small (including highly potent) molecules and peptides.
Pharmaceutical Development
Expert development & manufacturing solutions for all phases of clinical trials
Analytical & Solid State Services
Delivering comprehensive solutions to support drug substance (API) and drug product development programs.
Clinical Services
The most comprehensive Global Clinical Supply Chain Solution in the marketplace
Clinical Technologies
Unlock new efficiencies through industry-leading technology
Commercial Services
Providing flexible, quality led Commercial Solutions from EU & US facilities.

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Almac Discovery is a research driven company dedicated to the discovery and development of novel and innovative approaches to the treatment of cancer.

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Advancing human health requires exceptional people. Your talent, experience and passion will be the perfect match…

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Commercial Services

Customisable commercial solutions from product launch support through to drug product manufacturing and packaging.

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Clinical Technologies

Almac Clinical Technologies is here to help the biopharmaceutical industry bring new therapies to those in need by empowering trial sponsors.

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Clinical Services

Almac Clinical Services provides the most comprehensive Global Clinical Supply Chain Solution in the marketplace with over 30 years’ experience.

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Analytical & Solid State Services

Our highly skilled analysts deliver comprehensive solutions to support drug substance (API) and drug product development programs.

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Pharmaceutical Development

Specialising in solid, oral dosage forms; Almac provide expert Pharmaceutical Drug Product Development Solutions supporting early & late phase clinical trials.

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API Services & Chemical Development

Saving time and cost through the integration of our services and application of innovative Biocatalysis and Technology Solutions.

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Diagnostic Services

Almac Diagnostic Services is a stratified medicine company specialising in biomarker driven clinical trials. Our diagnostic experience spans oncology, immunology, CNS and infective diseases.

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Services

General

General

Diagnostic Services
Your Clinical Trial Diagnostic Partner
API Services & Chemical Development
Providing services for all stages of drug development for small (including highly potent) molecules and peptides.
Pharmaceutical Development
Expert development & manufacturing solutions for all phases of clinical trials
Analytical & Solid State Services
Delivering comprehensive solutions to support drug substance (API) and drug product development programs.
Clinical Services
The most comprehensive Global Clinical Supply Chain Solution in the marketplace
Clinical Technologies
Unlock new efficiencies through industry-leading technology
Commercial Services
Providing flexible, quality led Commercial Solutions from EU & US facilities.

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API, Chemical Development & Analytical Services Resources

Resources by service

Diagnostic Services API, Chemical Development & Analytical Services Pharmaceutical Development Clinical Services Clinical Technologies

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API, Chemical Development & Analytical Services

Article
Ticking a new box in enzyme chemistry
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Almac Voice
Melamine Contamination Testing
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Almac Voice
Disinfectant Efficacy Testing (DET)
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Article
Spatial requirement for PAMO for transformation of non-native linear substrate
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Almac Voice
EBF-European Bioanalysis Forum
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Article
The identification and use of robust transaminases from a domestic drain metagenome
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Poster
Identification and Structural Elucidation by Amino Acid Sequencing of Peptide Impurities by 2D-LC MS/MS
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Webinar
Identification and Structural Elucidation by Amino Acid Sequencing of Peptide Impurities by 2DlC-MS/MS
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Brochure
Analytical Services Brochure
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Brochure
NeoPeptides
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Brochure
Superior Peptide and Protein Solutions
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Brochure
cGMP Peptide Manufacture
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Brochure
Almac Sciences Brochure
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Brochure
Solid State Services Brochure
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Brochure
Comprehensive Chemokine Services Brochure
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Brochure
Integrated Enzyme Technologies Brochure
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Brochure
selectAZyme™ Brochure
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Technical Publication
Radionuclide Antibody-Conjugates, a Targeted Therapy Towards Cancer
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Technical Publication
Synthesis of isotopically labelled [14C]ZT-1, [d3]ZT-1 & (-)-[d3]huperzine A, a new generation of acetylcholinesterase inhibitors
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Technical Publication
Application of Radionuclides and Antibody-Drug Conjugates to Target Cancer
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Article
Biocatalysis: Genes to GMP
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Article
Modern Developments in Isotopic Labelling
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Article
Application of ω‑Transaminases in the Pharmaceutical Industry
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Article
Luminescent sensors and photonic switches
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Article
Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form
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Article
Catalytic mechanism of phenylacetone monooxygenases for non-native linear substrates
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Article
Practical Methods for Biocatalysis and Biotransformations 2
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Article
Biocatalysis is a Key Technology for Successful Chiral Synthesis at Almac
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Article
Biotransformations in chemical synthesis
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Article
Simple one-pot process for the bioresolution of tertiary amino ester protic ionic liquids using subtilisin
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Article
Highly stereoselective biocatalytic reduction of alpha-halo ketones
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Article
Efficient kinetic bioresolution of 2-nitrocyclohexanol
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Article
A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates
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Article
Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids
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Article
A novel lipase enzyme panel exhibiting superior activity and selectivity over lipase B from Candida antarctica for the kinetic resolution of secondary alcohols
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Article
Influence of the position of the substituent on the efficiency of lipase-mediated resolutions of 3-aryl alkanoic acids
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Article
Hydrolase-mediated resolution of the hemiacetal in 2-chromanols The impact of remote substitution
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Article
Benzoate dioxygenase from Ralstonia eutropha B9 – unusual regiochemistry of dihydroxylation permits rapid access to novel chirons
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Article
A Facile Stereoselective Biocatalytic Route to the Precursor of Woody Acetate
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Article
Development of an Acid-Washable Tag for the Separation of Enantiomers from Bioresolutions
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Article
Natural enzymes – key to 21st century process design
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Article
19th International Isotope Society (UK Group) Symposium: Synthesis & Applications of Labelled Compounds 2010
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Article
A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines
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Article
Biocatalytic Approaches to the Henry (Nitroaldol) Reaction
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Article
Engineering and application of P450 monooxygenases in pharmaceutical and metabolite synthesis
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Technical Publication
Isolation and Characterisation of a Halotolerant w-Transaminase from a Triassic Period Salt Mine and Its Application to Biocatalysis
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Article
Biocatalytic dearomatisation of para-fluorobenzoic acid
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Article
A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase
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Article
Efficient Magnetic Recycling of Covalently Attached Enzymes on Carbon-Coated Metallic Nanomagnets
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Article
Fluorescent PET (Photoinduced Electron Transfer) sensors as potent analytical tools
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Article
Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols
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Article
Making Hot ADCs
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Article
Rational Design of a (S)-Selective-Transaminase for Asymmetric Synthesis of (1S)-1-(1,1′-biphenyl-2-yl)ethanamine
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Article
Development and Scale-Up of an Antibody Drug Conjugate Tubulysin Payload
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Article
Radiolabeling is Still Hot
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Article
Enzymes from the salt of the Earth
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Article
Outsourcing peptide production for first in human studies
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White paper
Crystallisation of Pharmaceutical Compounds – the chemist’s role in protecting intellectual property
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Presentation
Carbon-14 Labelled Peptide APIs
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Presentation
Synthetic Strategies for 14C Labelling of Drug Molecules
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Presentation
Development of an Efficient and Practical Route for the Multi-kilogram Manufacture of Cyanopyridone AZ10527409 and Chloropyridine AZ10146848
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Presentation
Challenges in the Synthesis of Modified Histones
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Presentation
HPLC method development for analysis of a multi component drug product
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Presentation
Synthetic applications using selectAZyme technology
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Presentation
Development and Scale-up of a Photochemical Route to a Steroidal API
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Presentation
Carbon -14 Labelled Antibody Drug Conjugates & Peptides
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Presentation
Biocatalysis Development: Ered Assay Development and Naphthol Synthesis
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Presentation
Biocatalysis Development: From P450 to Scale-Up for Delivery of Chiral Intermediates
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Presentation
Biocatalysis Development: In Silico-Assisted Evolution of Transaminases and Chiral Amine Scale-Up
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Presentation
Mass Spectrometry: 5 Dimensional Structural Characterisation of Synthetic Peptides
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Presentation
Mass Spectrometry: An HPLC-MS/MS Assay Method for the Determination of Digoxin in Human Plasma and Urine
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Presentation
Peptide Manufacture: Unique Challenges in Process Development
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Presentation
Rational Design of Enzymes to fit the Process Chemist Timelines
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Presentation
Biocatalysis Development: Shortening the Path – Pharmaceutical Materials from Enzymatic Reactions
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Case study
Smarter, Faster Cheaper: How API Manufacturers Stay Ahead of The Game
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Case study
Key Strategies Central to Overcoming Poor API Solubility
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Case study
Mass Spectrometry: Trace Impurity Identification using Q-TOF Mass Spectroscopy
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Case study
Mass Spectrometry: Determination of Isotopic Purity by Accurate Mass LC/MS
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Case study
Mass Spectrometry: An HPLC-MS/MS Method for the Determination of Oxycodone, Noroxycodone & Oxymorphone in Human Plasma
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Case study
Biocatalysis and Quality in Drug Substance Manufacture
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Case study
Radiolabelling: Requirement for Synthesis of Non-GMP 14C API
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Case study
Mass Spectrometry: The Effect of Crystal Orientation on Raman Spectra
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Case study
Radiolabelling: Manufacture of 14C-Labelled Antibody Drug Conjugate
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Case study
Radiolabelling: Manufacture of 14C-Labelled Drug Product
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Case study
Radiolabelling: Synthesis of 14C-Labelled Peptide
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Article
Radiolabelling: Clinical Applications of Positron Emission Tomography (PET) Imaging in Medicine: Oncology, Brain Diseases and Cardiology
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Article
Biocatalysis: Greener, sustainable processes using efficient biocatalyst purification tools at Almac Sciences
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Article
Solid State Services: Why are Solid Forms Still Causing Headaches?
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Article
Biocatalysis: Accelerating Chemical Development and Minimising Cost for Fine Chemical / API Manufacture and Metabolite Synthesis
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Article
Biocatalysis: Overcoming Equilibrium Issues with Carbonyl Reductase Enzymes
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Article
Radiolabelling: Keeping tags on biomolecules
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Article
Biocatalysis: A Three-Enzyme System Involving an Ene-Reductase for Generating Valuable Chiral Building Blocks
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Article
Radiolabelling: Seeing Through The Mist
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Article
Antibody-Drug Conjugates (ADCs) – Biotherapeutic bullets
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Article
Analytical Services: Overcoming challenges in particle size measurement by laser diffraction technique
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Article
Carbon-14 Bioconjugation: Peptides and Antibody Drug Conjugates
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Article
Technology-driven isotopic labelling in API development
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Article
Who needs “normal”peptides?
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Article
Characterisation of a novel w-transaminase from a Triassic salt mine metagenome
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Publication
Carbon-14 labelled API manufacturing
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Publication
Development of an Efficient and Practical Route for the Multikilogram Manufacture of Ethyl 5-Cyano-2-methyl-6-oxo-1,6- dihydropyridine-3-carboxylate and Ethyl 6-Chloro-5-cyano-2- methylnicotinate.
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Publication
Positron Emission Tomography Neuro-Imaging
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Publication
Dynamic kinetic resolution of 2-methyl-2-nitrocyclohexanol: Combining the intramolecular nitroaldol (Henry) reaction & lipasecatalysed resolution
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White paper
Early phase drug development: Assessing, predicting and formulating with delivery in mind
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Publication
Enzyme Processes, Past Present and Future
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Poster
Limit tests by XRPD
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Webinar
Limit Test: Ensuring Consistency in Polymorphic Drug Substances & Products
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Publication
Antibody-Drug Conjugates: Carbon-14 Labeling Requirements
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White paper
Streamlined Preparation of Immobilized Candida antarctica Lipase B
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White paper
Modern Perspectives on Peptide Synthesis
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White paper
Ensuring Consistency in Polymorphic Drug Substances and Products
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Article
Characterisation of a solvent-tolerant haloarchaeal (R)-selective transaminase isolated from a Triassic period salt mine
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