API, Chemical Development & Analytical Services Resources

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API, Chemical Development & Analytical Services

Technical Publication
FAST Hydrogenations as a Continuous Platform for Green Aromatic Nitroreductions
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Almac Voice
Conducting Nitrosamine impurity testing and analysis on drug substance and drug product
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Almac Voice
Bioanalytical Method Validation – FDA & EMA perspectives
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Technical Publication
A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry
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Technical Publication
Sequential Palladium-Catalyzed Allylic Alkylation/retro-Dieckmann Fragmentation Strategy for the Synthesis of α‑Substituted Acrylonitriles
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Technical Publication
Metagenomic ene-reductases for the bioreduction of sterically challenging enones
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Technical Publication
Combining luminescence, coordination and electron transfer for signalling purposes
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Technical Publication
Structural effects on the pH-dependent fluorescence of naphthalenic derivatives and consequences for sensing/switching
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Technical Publication
Preparative access to medicinal chemistry related chiral alcohols using carbonyl reductase technology
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Technical Publication
Building pH Sensors into Paper-Based Small-Molecular Logic Systems for Very Simple Detection of Edges of Objects
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Technical Publication
Biocatalysis in seawater: Investigating a halotolerant 𝝎-transaminase capable of converting furfural in a seawater reaction medium
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Technical Publication
Synthesis of carbon‐14–labelled peptides
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Technical Publication
An Industrial Perspective of Ene Reductase (ERED) Biocatalysis
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Article
Changing the shape of GMP peptide manufacture
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Article
Managing and redesigning chemical processes with enzymes
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Technical Publication
Reaction Mechanism of Histone Demethylation in αKG-dependent Non-Heme Iron Enzymes
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Technical Publication
Mechanism of Phosphatidylglycerol Activation Catalyzed by Prolipoprotein Diacylglyceryl Transferase
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Technical Publication
Molecular memory with downstream logic processing exemplified by switchable and self-indicating guest capture and release
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Technical Publication
Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution
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Article
Ticking a new box in enzyme chemistry
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Almac Voice
Melamine Contamination Testing
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Almac Voice
Disinfectant Efficacy Testing (DET)
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Article
Spatial requirement for PAMO for transformation of non-native linear substrate
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Almac Voice
EBF-European Bioanalysis Forum
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Technical Publication
The identification and use of robust transaminases from a domestic drain metagenome
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Poster
Identification and Structural Elucidation by Amino Acid Sequencing of Peptide Impurities by 2D-LC MS/MS
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Webinar
Identification and Structural Elucidation by Amino Acid Sequencing of Peptide Impurities by 2DlC-MS/MS
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Brochure
Analytical Services Brochure
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Brochure
NeoPeptides
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Brochure
Superior Peptide and Protein Solutions
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Brochure
cGMP Peptide Manufacture
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Brochure
Almac Sciences Brochure
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Brochure
Solid State Services Brochure
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Brochure
Comprehensive Chemokine Services Brochure
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Brochure
Integrated Enzyme Technologies Brochure
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Brochure
selectAZyme™ Brochure
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Technical Publication
Radionuclide Antibody-Conjugates, a Targeted Therapy Towards Cancer
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Technical Publication
Synthesis of isotopically labelled [14C]ZT-1, [d3]ZT-1 & (-)-[d3]huperzine A, a new generation of acetylcholinesterase inhibitors
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Technical Publication
Application of Radionuclides and Antibody-Drug Conjugates to Target Cancer
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Article
Biocatalysis: Genes to GMP
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Article
Modern Developments in Isotopic Labelling
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Technical Publication
Application of ω‑Transaminases in the Pharmaceutical Industry
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Article
Luminescent sensors and photonic switches
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Technical Publication
Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form
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Article
Catalytic mechanism of phenylacetone monooxygenases for non-native linear substrates
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Technical Publication
Practical Methods for Biocatalysis and Biotransformations 2
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Article
Biocatalysis is a Key Technology for Successful Chiral Synthesis at Almac
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Article
Biotransformations in chemical synthesis
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Technical Publication
Simple one-pot process for the bioresolution of tertiary amino ester protic ionic liquids using subtilisin
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Technical Publication
Highly stereoselective biocatalytic reduction of alpha-halo ketones
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Technical Publication
Efficient kinetic bioresolution of 2-nitrocyclohexanol
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Technical Publication
A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates
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Technical Publication
Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids
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Technical Publication
A novel lipase enzyme panel exhibiting superior activity and selectivity over lipase B from Candida antarctica for the kinetic resolution of secondary alcohols
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Technical Publication
Influence of the position of the substituent on the efficiency of lipase-mediated resolutions of 3-aryl alkanoic acids
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Technical Publication
Hydrolase-mediated resolution of the hemiacetal in 2-chromanols The impact of remote substitution
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Technical Publication
Benzoate dioxygenase from Ralstonia eutropha B9 – unusual regiochemistry of dihydroxylation permits rapid access to novel chirons
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Technical Publication
A Facile Stereoselective Biocatalytic Route to the Precursor of Woody Acetate
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Technical Publication
Development of an Acid-Washable Tag for the Separation of Enantiomers from Bioresolutions
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Article
Natural enzymes – key to 21st century process design
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Technical Publication
19th International Isotope Society (UK Group) Symposium: Synthesis & Applications of Labelled Compounds 2010
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Technical Publication
A metagenomics approach for new biocatalyst discovery: application to transaminases and the synthesis of allylic amines
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Technical Publication
Biocatalytic Approaches to the Henry (Nitroaldol) Reaction
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Technical Publication
Engineering and application of P450 monooxygenases in pharmaceutical and metabolite synthesis
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Technical Publication
Isolation and Characterisation of a Halotolerant w-Transaminase from a Triassic Period Salt Mine and Its Application to Biocatalysis
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Technical Publication
Biocatalytic dearomatisation of para-fluorobenzoic acid
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Technical Publication
A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase
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Technical Publication
Efficient Magnetic Recycling of Covalently Attached Enzymes on Carbon-Coated Metallic Nanomagnets
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Technical Publication
Fluorescent PET (Photoinduced Electron Transfer) sensors as potent analytical tools
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Technical Publication
Ene Reductase Enzymes for the Aromatisation of Tetralones and Cyclohexenones to Naphthols and Phenols
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Article
Making Hot ADCs
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Technical Publication
Rational Design of a (S)-Selective-Transaminase for Asymmetric Synthesis of (1S)-1-(1,1′-biphenyl-2-yl)ethanamine
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Article
Development and Scale-Up of an Antibody Drug Conjugate Tubulysin Payload
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Article
Radiolabeling is Still Hot
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Article
Enzymes from the salt of the Earth
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Article
Outsourcing peptide production for first in human studies
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White paper
Crystallisation of Pharmaceutical Compounds – the chemist’s role in protecting intellectual property
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Presentation
Carbon-14 Labelled Peptide APIs
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Presentation
Synthetic Strategies for 14C Labelling of Drug Molecules
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Presentation
Development of an Efficient and Practical Route for the Multi-kilogram Manufacture of Cyanopyridone AZ10527409 and Chloropyridine AZ10146848
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Presentation
Challenges in the Synthesis of Modified Histones
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Presentation
HPLC method development for analysis of a multi component drug product
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Presentation
Synthetic applications using selectAZyme technology
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Presentation
Development and Scale-up of a Photochemical Route to a Steroidal API
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Presentation
Carbon -14 Labelled Antibody Drug Conjugates & Peptides
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Presentation
Biocatalysis Development: Ered Assay Development and Naphthol Synthesis
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Presentation
Biocatalysis Development: From P450 to Scale-Up for Delivery of Chiral Intermediates
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Presentation
Biocatalysis Development: In Silico-Assisted Evolution of Transaminases and Chiral Amine Scale-Up
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Presentation
Mass Spectrometry: 5 Dimensional Structural Characterisation of Synthetic Peptides
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Presentation
Mass Spectrometry: An HPLC-MS/MS Assay Method for the Determination of Digoxin in Human Plasma and Urine
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Presentation
Peptide Manufacture: Unique Challenges in Process Development
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Presentation
Rational Design of Enzymes to fit the Process Chemist Timelines
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Presentation
Biocatalysis Development: Shortening the Path – Pharmaceutical Materials from Enzymatic Reactions
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Case study
Smarter, Faster Cheaper: How API Manufacturers Stay Ahead of The Game
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Case study
Key Strategies Central to Overcoming Poor API Solubility
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Case study
Mass Spectrometry: Trace Impurity Identification using Q-TOF Mass Spectroscopy
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Case study
Mass Spectrometry: Determination of Isotopic Purity by Accurate Mass LC/MS
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Case study
Mass Spectrometry: An HPLC-MS/MS Method for the Determination of Oxycodone, Noroxycodone & Oxymorphone in Human Plasma
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Case study
Biocatalysis and Quality in Drug Substance Manufacture
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Case study
Radiolabelling: Requirement for Synthesis of Non-GMP 14C API
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Case study
Mass Spectrometry: The Effect of Crystal Orientation on Raman Spectra
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Case study
Radiolabelling: Manufacture of 14C-Labelled Antibody Drug Conjugate
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Case study
Radiolabelling: Manufacture of 14C-Labelled Drug Product
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Case study
Radiolabelling: Synthesis of 14C-Labelled Peptide
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Article
Radiolabelling: Clinical Applications of Positron Emission Tomography (PET) Imaging in Medicine: Oncology, Brain Diseases and Cardiology
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Article
Biocatalysis: Greener, sustainable processes using efficient biocatalyst purification tools at Almac Sciences
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Article
Solid State Services: Why are Solid Forms Still Causing Headaches?
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Article
Biocatalysis: Accelerating Chemical Development and Minimising Cost for Fine Chemical / API Manufacture and Metabolite Synthesis
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Technical Publication
Biocatalysis: Overcoming Equilibrium Issues with Carbonyl Reductase Enzymes
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Article
Radiolabelling: Keeping tags on biomolecules
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Technical Publication
Biocatalysis: A Three-Enzyme System Involving an Ene-Reductase for Generating Valuable Chiral Building Blocks
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Article
Radiolabelling: Seeing Through The Mist
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Article
Antibody-Drug Conjugates (ADCs) – Biotherapeutic bullets
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Article
Analytical Services: Overcoming challenges in particle size measurement by laser diffraction technique
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Article
Carbon-14 Bioconjugation: Peptides and Antibody Drug Conjugates
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Article
Technology-driven isotopic labelling in API development
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Article
Who needs “normal”peptides?
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Technical Publication
Characterisation of a novel w-transaminase from a Triassic salt mine metagenome
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Publication
Carbon-14 labelled API manufacturing
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Publication
Development of an Efficient and Practical Route for the Multikilogram Manufacture of Ethyl 5-Cyano-2-methyl-6-oxo-1,6- dihydropyridine-3-carboxylate and Ethyl 6-Chloro-5-cyano-2- methylnicotinate.
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Publication
Positron Emission Tomography Neuro-Imaging
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Technical Publication
Dynamic kinetic resolution of 2-methyl-2-nitrocyclohexanol: Combining the intramolecular nitroaldol (Henry) reaction & lipasecatalysed resolution
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White paper
Early phase drug development: Assessing, predicting and formulating with delivery in mind
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Publication
Enzyme Processes, Past Present and Future
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Poster
Limit tests by XRPD
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Webinar
Limit Test: Ensuring Consistency in Polymorphic Drug Substances & Products
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Publication
Antibody-Drug Conjugates: Carbon-14 Labeling Requirements
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Technical Publication
Streamlined Preparation of Immobilized Candida antarctica Lipase B
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White paper
Modern Perspectives on Peptide Synthesis
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White paper
Ensuring Consistency in Polymorphic Drug Substances and Products
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Technical Publication
Characterisation of a solvent-tolerant haloarchaeal (R)-selective transaminase isolated from a Triassic period salt mine
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