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Mass Spectrometry: Determination of Isotopic Purity by Accurate Mass LC/MS
Following the synthesis of isotopic labelled APIs at Almac, or stability testing, it is often necessary to accurately determine the isotopic enrichment of the compounds by mass spectrometry. This process is often complicated if the compound in question contains a variety of labelled atoms, including C, N and H, or where the isotopes resolution between the isotopes of labelled compounds and this has allowed more accurate extraction of these isotopes than ever before. With this high degree of mass accuracy, it is possible to accurately quantify the labelled composition of the compounds in question.
A case study for the determination of isotopic purity of a compound manufactured at Almac which contained two C atoms and two N atoms is presented.
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