Home / Knowledge Center /
Technical Publication

Development of an Acid-Washable Tag for the Separation of Enantiomers from Bioresolutions

A separation tool involving the use of a vinyl ester amino acid as acyl donor in a bioresolution has been developed. The acid-washable acyl group acts as a removable tag, facilitating separation of the secondary alcohol from the bioresolution product mixture.
The use of these acyl donors from cheap, commercially available amino acids has been demonstrated in conjunction with the hydrolase enzyme Candida antarctica lipase B in the selective acylation of a variety of secondary alcohols.

View Resource
Almac Logo

Almac API, Chemical Development, Analytical & Solid State Services

Almac Sciences provides integrated services from development to commercial scale of advanced intermediates and Active Pharmaceutical Ingredients (API).

We provide a range of services for small molecules (including highly potent) and peptides. We have a proven track record of saving time and cost through the integration of our services and application of innovative biocatalysis and technology solutions.

Learn More

We offer a full suite of analytical testing for a range of different product types including small molecules, peptides, biologics, conjugates, potent and controlled substances.

Our vast pool of scientific knowledge can help to overcome the analytical challenges that typically arise during drug development.

Learn More

Download here instantly

This website uses cookies. By continuing to browse the site, you are agreeing to our use of cookies