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A Solution To Overcome The Solution Stability Challenges Associated With Determination Of Residual Phosphine Ligands In Active Pharmaceutical Ingredients (API) And Their Intermediates
A Solution To Overcome The Solution Stability Challenges Associated With Determination Of Residual Phosphine Ligands In Active Pharmaceutical Ingredients (API) And Their Intermediates
In Suzuki–Miyaura coupling processes, monitoring residual phosphine ligands is essential, yet challenging due to their presence in both oxidised and non‑oxidised forms—each with different UV responses and solubility profiles. These differences often lead to poor accuracy and precision, especially as controlling oxidation in standards and samples is difficult.
In this paper, James Sweatman, Analytical Investigator at Almac Sciences, presents a derivatisation approach that converts all phosphines to a stable oxidised form, enabling reliable and consistent quantification across materials.
