Advancing Counterion Analysis: A Practical HILIC–ELSD Approach for Modern Pharmaceutical Laboratories
Accurate counterion analysis is an important consideration in pharmaceutical development and quality control. This case study explores a practical HILIC-ELSD approach that enables the separation and quantification of both anionic and cationic counterions while also resolving the API from its associated salt. Focusing on chloride and sodium, the study demonstrates how the methodology can provide accurate, reproducible results and offer a robust, flexible alternative to traditional counterion analysis techniques for routine pharmaceutical workflows.
Read the case study to explore how HILIC-ELSD can provide a practical and reliable approach to pharmaceutical counterion analysis.