Precision in Biologic Development: Leveraging Orthogonal Techniques for Superior Insights
Precise analytical methods are essential for maintaining product quality and supporting the development of increasingly complex biologics. This case study explores how Almac Sciences developed an orthogonal chromatographic approach to quantify maleimide reactivity in peptide conjugation after identifying limitations with a commercial assay. Using cysteine and mercaptoethylamine, the method demonstrated high reactivity, specificity and reproducibility, enabling more reliable monitoring of conjugation efficiency and highlighting the value of tailored analytical approaches in biologic development.
Read the case study to discover how orthogonal analytical techniques can provide greater precision and confidence in biologic development.