Validation of a GC-FID headspace method for quantitative detection of silicone oils (siloxane polymers) within the lyophilisation life cycle
Silicone oils play an important role in heat transfer during lyophilisation, but potential leaks can introduce siloxane polymers into the product chamber and create contamination risks. In this case study, Damien Higgins, Analytical Team Leader, explores the development and validation of a GC-FID headspace method for the quantitative detection of eight siloxane polymers. The study demonstrates how the method can support equipment cleaning assessments, contamination control and testing throughout the lyophilisation process lifecycle.
Read the case study to discover how GC-FID headspace analysis can support effective siloxane detection and contamination control throughout the lyophilisation lifecycle.