{"id":1056,"date":"2023-03-24T15:49:30","date_gmt":"2023-03-24T15:49:30","guid":{"rendered":"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/?page_id=1056"},"modified":"2025-07-16T11:29:43","modified_gmt":"2025-07-16T10:29:43","slug":"solubility-enhancement","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/solubility-enhancement\/","title":{"rendered":"Solubility Enhancement"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\" id=\"h-improving-the-bioavailability-of-your-compound\">Improving the Bioavailability of your Compound<\/h4>\n\n\n\n<p>Many APIs have poor physicochemical properties that may struggle to get sufficient exposure when dosed to patients. We can develop a variety of formulations that potentially offer improvements in the bioavailability of your compound.<\/p>\n\n\n\n<p>Through our advanced techniques, we can offer:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Micronisation of API<\/li>\n\n\n\n<li>Spray dried amorphous material (aqueous &amp; solvent capabilities)<\/li>\n\n\n\n<li>Solubilised \/ lipid-based systems<\/li>\n<\/ul>\n\n\n\n<p>Never limiting ourselves to the technologies we have available in-house, we are happy to accommodate your particular approach or platform technology and will work with external parties.<\/p>\n\n\n\n<p>To tackle the bioavailability challenges of your compound, our knowledgeable scientists will assess different formulations by developing discriminatory dissolution methods and by arranging comparative bioavailability studies. With their expertise, they can also devise a practical way to take one of these approaches forward to GMP manufacture.<\/p>\n\n\n\n\n    <div class=\"u-flex u-flex-justify-start   u-m-t-auto \">\n                            <a class=\"c-btn c-btn-primary c-btn--red\" href=\"\/pharmaceutical-development\/contact-us\/\">Contact Us<\/a>\n                    <\/div>\n","protected":false},"excerpt":{"rendered":"<p>Improving the Bioavailability of your Compound Many APIs have poor physicochemical properties that may struggle to get sufficient exposure when dosed to patients. We can develop a variety of formulations that potentially offer improvements in the bioavailability of your compound. Through our advanced techniques, we can offer: Never limiting ourselves to the technologies we have [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":11,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1056","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Solubility Enhancement - Pharmaceutical Development<\/title>\n<meta name=\"description\" content=\"Almac can develop a variety of formulations that potentially offer improvements in the bioavailability of your compound.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/solubility-enhancement\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Solubility Enhancement\" \/>\n<meta property=\"og:description\" content=\"Almac can develop a variety of formulations that potentially offer improvements in the bioavailability of your compound.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/solubility-enhancement\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmaceutical Development\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-16T10:29:43+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/wp-content\/uploads\/sites\/5\/2020\/11\/Almac_Logo.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"334\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/solubility-enhancement\/\",\"url\":\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/solubility-enhancement\/\",\"name\":\"Solubility Enhancement - 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