{"id":11,"date":"2020-01-23T10:53:48","date_gmt":"2020-01-23T10:53:48","guid":{"rendered":"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/?page_id=11"},"modified":"2026-02-24T12:25:08","modified_gmt":"2026-02-24T12:25:08","slug":"early-phase-pharmaceutical-drug-product-development","status":"publish","type":"page","link":"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/","title":{"rendered":"Early Phase Pharmaceutical Drug Product Development"},"content":{"rendered":"\n<h4 class=\"wp-block-heading\" id=\"h-almac-s-experienced-formulation-development-scientists-can-develop-a-range-of-oral-dose-formulations-to-support-your-early-phase-clinical-trials\">Almac\u2019s experienced formulation development scientists can develop a range of oral dose formulations to support your early phase clinical trials.<\/h4>\n\n\n\n<p>With both <a href=\"\/pharmaceutical-development\/non-gmp-development\/\">non-GMP<\/a> and GMP facilities, we offer flexible and efficient solutions to help you develop a fit-for-purpose formulation and manufacture early phase clinical materials.<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-preclinical-or-phase-1-first-in-human-solutions\">Preclinical or Phase 1 First-in-Human solutions<\/h5>\n\n\n\n<p>With a proven capability of handling potent APIs and peptide pharmaceutical drug programmes, our full suite of Xcelodose, All-Fill and specialised technologies help accelerate timelines whilst maintaining high quality.<\/p>\n\n\n\n<figure class=\"wp-block-table\">\n  <table class=\"has-fixed-layout\">\n    <style>\n      table td {\n        vertical-align: top;\n      }\n    <\/style>\n    <tbody>\n      <tr>\n        <td><strong>Direct API in capsule<\/strong><\/td>\n        <td><strong>API \/ Powder in bottle<\/strong><\/td>\n        <td><strong>Conventional oral dose presentations<\/strong><\/td>\n      <\/tr>\n      <tr>\n        <td>\u2022 Xcelodose 600S precision powder micro-dosing<\/td>\n        <td>\u2022 All-Fill for ultra-low doses<br>\u2022 Co-solvent screening, instruction for reconstitution and in-use stability<\/td>\n        <td>\u2022 Manufacturing of prototype tablets, capsules &#038; powders<\/td>\n      <\/tr>\n    <\/tbody>\n  <\/table><\/figure>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Our range of technology is available to work with APIs and highly potent APIs in high containment processing environments. This includes:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dry blending<\/li>\n\n\n\n<li>Dry granulation \/ Roller compaction<\/li>\n\n\n\n<li>Wet granulation (aqueous and solvent capabilities)<\/li>\n\n\n\n<li>Encapsulation (Xcelodose)<\/li>\n\n\n\n<li>Compression<\/li>\n\n\n\n<li>Coating (aqueous and solvent capabilities)<\/li>\n\n\n\n<li>Potent processing<\/li>\n<\/ul>\n\n\n\n<p>If you\u2019re planning early PK, IND-enabling or Phase I-ready activities, our expert technical team can guide you to the fastest and most reliable path based on your molecule and timeline.<\/p>\n\n\n\n<p>With comprehensive chemical and microbiological laboratories, our <a href=\"https:\/\/www.almacgroup.com\/analytical-solid-state\/\">expert analytical solutions<\/a> fully support all phases of clinical trials.<\/p>\n\n\n\n<p>When understanding API properties is critical to developing a suitable formulation for early phase First in Human trials, our&nbsp;<a href=\"https:\/\/www.almacgroup.com\/analytical-solid-state\/solid-state-services\/\">physical sciences<\/a>&nbsp;group, who work closely with our formulators, can gain full insight into the unique physiochemical properties of your API.&nbsp;<\/p>\n\n\n\n<div style=\"height:20px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"h-ready-to-scale-up\">Ready to scale up?<\/h5>\n\n\n\n<p>When we develop manufacturing processes, our scientists look to the future to ensure your formulation can be scaled up for&nbsp;<a href=\"https:\/\/www.almacgroup.com\/pharmaceutical-development\/late-phase-pharmaceutical-development\/\">later stage clinical supply<\/a>.&nbsp; Working with the same dedicated project manager and multi-disciplinary team, guarantees scientific continuity as your product progresses through its clinical trials.&nbsp; &nbsp;<\/p>\n\n\n\n\n    <div class=\"  u-m-t-auto \">\n                            <a class=\"c-btn c-btn-primary c-btn--red\" href=\"\/pharmaceutical-development\/contact-us\/\">Contact Us<\/a>\n                    <\/div>\n\n\n\n<div style=\"height:32px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t<article class=\"o-grid o-grid--full\">\n\n\t\t<div class=\"o-grid__item u-width-full u-m-t6 u-m-t4@m u-m-b4\">\n\t\t\t<h2 class=\"u-normal u-a-center\">Related Resources<\/h2>\n\t\t<\/div>\n\n\t\t<div class=\"u-flex u-flex-justify-center u-flex-wrap u-width-full c-news-panels__slider js-news-panels\">\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/pharmaceutical-development-brochure\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/wp-content\/uploads\/sites\/5\/2022\/09\/PS_Pills_KC_Tile.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Pharmaceutical Development Brochure<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t\t\t<article class=\"u-width-1\/4 u-width-half@l u-width-full@m\">\n\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/achieving-faster-formulation-of-solid-oral-dosage-forms-for-first-in-human-supplies-using-drug-in-capsule-approach-2\/\">\n\t\t\t\t\t\n\t\t\t\t\t\t<div class=\"c-news-panels u-a-center\">\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__img lazyload\" 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class=\"c-news-panels__img lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/wp-content\/uploads\/sites\/5\/2024\/02\/Potent-Processing-and-Manufacture-Mobile-768.jpg&#039;)\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-meta\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"c-news-panels__content u-width-full u-p-x2 u-p-y2 u-bg-white\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<p class=\"u-text-18 u-normal\">Potent Processing and Manufacture Brochure<\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t<\/div>\n\t<\/article>\n\n\n<!-- <article id=\"related\">\n\t<div class=\"o-grid\">\n\t\t\t\t<div class=\"o-grid__item u-width-full u-a-center\">\n\t\t\t\t\t\t\t<h3 class=\"u-normal u-m-b4\">Related Resources<\/h3>\n\t\t\t\t\t<\/div>\n\t\n\t\t<div class=\"u-flex u-flex-justify-center u-flex-wrap u-width-full c-resources__slider js-resources-panels\">\n\t\t\t\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-4\/12 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/pharmaceutical-development-brochure\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/wp-content\/uploads\/sites\/5\/2022\/09\/PS_Pills_KC_Tile.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Pharmaceutical Development Brochure<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-4\/12 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/achieving-faster-formulation-of-solid-oral-dosage-forms-for-first-in-human-supplies-using-drug-in-capsule-approach-2\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/wp-content\/uploads\/sites\/5\/2020\/03\/Clinical_Services_21.png&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">White Paper<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Achieving faster formulation of solid oral dosage forms for First-In-Human supplies using drug in capsule approach<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\n\t\t\t\t\t\t\t\t\t<article class=\"c-resources__grid u-width-4\/12 u-width-half@l u-width-full@m\">\n\t\t\t\t\n\t\t\t\t\t<a href=\"https:\/\/www.almacgroup.com\/knowledge\/library\/potent-processing-and-manufacture-brochure\/\" target=\"\">\n\t\t\t\t\t\t<div class=\"c-resources c-overlay__ u-a-center lazyload\" style=\"background-image:inherit;\" data-bg-image=\"url(&#039;https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/wp-content\/uploads\/sites\/5\/2024\/02\/Potent-Processing-and-Manufacture-Mobile-768.jpg&#039;)\">\n\t\t\t\t\t\t\t<div class=\"c-resources__gradient-inner\">\n\t\t\t\t\t\t\t\t<p class=\"c-resources__type u-text-small u-bold u-m-b1\">Brochure<\/p>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<h3 class=\"u-normal\">Potent Processing and Manufacture Brochure<\/h3>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/article>\n\t\t\t\t\t<\/div>\n\t<\/div>\n<\/article> -->\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Almac\u2019s experienced formulation development scientists can develop a range of oral dose formulations to support your early phase clinical trials. With both non-GMP and GMP facilities, we offer flexible and efficient solutions to help you develop a fit-for-purpose formulation and manufacture early phase clinical materials. Preclinical or Phase 1 First-in-Human solutions With a proven capability [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-11","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v25.3.1 (Yoast SEO v26.3) - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Early Phase Pharmaceutical Drug Product Development - Pharmaceutical Development<\/title>\n<meta name=\"description\" content=\"Our experienced formulation development scientists can develop a range of oral dose formulations to support your early phase clinical trials.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Early Phase Pharmaceutical Drug Product Development\" \/>\n<meta property=\"og:description\" content=\"Our experienced formulation development scientists can develop a range of oral dose formulations to support your early phase clinical trials.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/\" \/>\n<meta property=\"og:site_name\" content=\"Pharmaceutical Development\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T12:25:08+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/wp-content\/uploads\/sites\/5\/2020\/11\/Almac_Logo.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"640\" \/>\n\t<meta property=\"og:image:height\" content=\"334\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/\",\"url\":\"https:\/\/www.almacgroup.com\/pharmaceutical-drug-product-development\/early-phase-pharmaceutical-drug-product-development\/\",\"name\":\"Early Phase Pharmaceutical Drug Product Development - 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