Articles & Publications
Publication
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Nature Chemical Biology volume 14, pages 118–125(2018)
Gerald Gavory, Colin R O’Dowd, Matthew D Helm, Jakub Flasz, Elias Arkoudis, Anthony Dossang, Caroline Hughes, Eamon Cassidy, Keeva McClelland, Ewa Odrzywol, Natalie Page, Oliver Barker, Hugues Miel & Timothy Harrison
Publication
Identification and characterisation of dual inhibitors of the USP25/28 deubiquitinating enzyme subfamily
ACS Chem Biol, 2017, 12, 3113-3125
Jonathan D Wrigley, Gerald Gavory, Iain Simpso, Marian Preston 1 , Helen Plant, Jenna Bradle , Anne U Goeppert, Ewelina Rozycka, Gareth Davies, Jarrod Walsh, Andrea Valentine, Keeva McClelland, Krzysztofa Ewa Odrzywol , Jonathan Renshaw, Joanna Boros, Jonathan Tart, Lindsey Leach, Thorsten Nowak, Richard A Ward, Timothy Harrison, David M Andrews
Publication
Identification and Structure-Guided Development of Pyrimidinone Based USP7 Inhibitors
ACS Med. Chem. Lett. 2018, 9, 3, 238–243
Colin R. O’Dowd, Matthew D. Helm, J. S. Shane Rountree, Jakub T. Flasz, Elias Arkoudis, Hugues Miel, Peter R. Hewitt, Linda Jordan, Oliver Barker, Caroline Hughes, Ewelina Rozycka, Eamon Cassidy, Keeva McClelland, Ewa Odrzywol, Natalie Page, Stephanie Feutren-Burton, Scarlett Dvorkin, Gerald Gavory, Timothy Harrison
Article
Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma
Sci Rep 14, 32121 (2024)
Leanne Stevenson, Lauren Cairns, Xiaodun Li, Sriganesh Jammula, Harriet Taylor, Rosalie Douglas, Niamh McCabe, Gerald Gavory, Xavier Jacq, Rebecca C. Fitzgerald, Richard D. Kennedy, Timothy Harrison & Richard C. Turkington
Article
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
Clin Transl Med. 2024; 14:e1648.
Anamarija Jurisic, Pei-Ju Sung, Mark Wappett, Julien Daubriac, Ian T. Lobb, Wei-Wei Kung, Nyree Crawford, Natalie Page, Eamon Cassidy, Stephanie Feutren-Burton, J. S. Shane Rountree, Matthew D. Helm, Colin R. O’Dowd, Richard D. Kennedy, Gerald Gavory, Aaron N. Cranston, Daniel B. Longley, Xavier Jacq, Timothy Harrison
Article
Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development
Sci Rep 12, 15715 (2022).
Natalie Page, Mark Wappett, Colin R. O’Dowd, Martin O’Rourke, Gerald Gavory, Lixin Zhang, J. S. Shane Rountree, Linda Jordan, Oliver Barker, Hayley Gibson, Caroline Boyd, Stephanie Feutren-Burton, Estelle McLean, Graham Trevitt & Timothy Harrison
Article
A first-in-human Phase I dose-escalation trial of the novel therapeutic peptide, ALM201, demonstrates a favourable safety profile in unselected patients with ovarian cancer and other advanced solid tumours
Br J Cancer 127, 92–101 (2022)
Aya El Helali, Ruth Plummer, Gordon C. Jayson, Vicky M. Coyle, Yvette Drew, Nerissa Mescallado, Noor Harris, Andrew R. Clamp, Janine McCann, Helen Swaisland, Richard D. Kennedy, Aaron N. Cranston & Richard H. Wilson
Article
SynLeGG: analysis and visualization of multiomics data for discovery of cancer ‘Achilles Heels’ and gene function relationships
Nucleic Acids Research, Volume 49, Issue W1, 2 July 2021, Pages W613–W618
Mark Wappett , Adam Harris , Alexander L R Lubbock , Ian Lobb , Simon McDade , Ian M Overton