Wee-1

Target

Wee1-like protein kinase

Modality

Small molecule

Descriptor

Oral, selective Wee1 inhibitor

Context

Many cancer treatments such as radiation, antimetabolites, alkylating agents, DNA topoisomerase inhibitors and platinum compounds damage DNA in cells. The cellular response is to arrest the cell cycle temporarily to allow for DNA repair hence reducing the effects of chemotherapy. The WEE1 kinase is a key regulator of the G2 checkpoint and there is emerging evidence demonstrating that it also has critical functions as a regulator of the S phase and as an epigenetic modifier. These findings in conjunction with the frequently found functional inactivation of p53, which controls the G1 cell cycle arrest, means that Wee1 inhibitors may have great value across a multitude of cancer types in both combination and monotherapy modalities.

Status

Novel Wee1 inhibitors have been designed and optimised which exhibit high potency (IC50 < 5 nM) and excellent selectivity profile over a panel of more than 50 kinases.  These inhibitors demonstrate potent anti-proliferative activity in a variety of cell lines from different tissues of origin both in combination with genotoxics and as a single agent.

Partnering

Wee1 inhibitors have the potential to have clinical utility across a broad range of cancer indications.

Worldwide rights available please contact martin.wiles@almacgroup.com