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Site-specific AF647® Labelled Chemokines

Our premium products are the AF647®[1] labelled chemokines, which are unique to Almac.

The chemokines are labelled selectively at or near the C-terminus of the protein in a selective manner which ensures that only a single dye molecule is incorporated. The bright AF647® dye enables straightforward use in applications such as flow cytometry[2], and receptor recognition[3] studies.

 Chemokine LigandChemokine NameReceptorsCatalogue code
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CCL1I-309CCR8CAF-7
CCL2MCP-1CCR2CAF-2
CCL3MIP-1αCCR1/CCR5CAF-1
CCL4h-MIP-1-betaCCR5CAF-23
CCL5RANTESCCR1/CCR3/CCR4/CCR5CAF-8
CCL8h-MCP-2CCR1/CCR2/CCR3/CCR5CAF-18
CCL11EotaxinCCR3CAF-3
CCL15MIP-5CCR1/CCR3CAF-19
CCL17h-TARCCCR4CAF-16
CCL18PARCUnknownCAF-21
CCL19MIP-3βCCR7CAF-6
CCL20MIP-3αCCR6CAF-5
CCL22MDCCCR4CAF-4
CCL25TECKCCR9CAF-15
CCL28h-MECCCR10CAF-20
CXCL8IL-8CXCR1/CXCR2CAF-9
CXCL10IP-10CXCR3CAF-10
CXCL11ITACCXCR3CAF-13
CXCL12SDF-1αCXCR4CAF-11
CXCL12SDF-1βCXCR4CAF-22
CXCL13MLCCXCR5CAF-12
CXCL14BRAKUnknownCAF-17
CX3CL1FractalktineCX3CR1CAF-14

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[1] AF647®-labelled chemokines are licensed for research use under patents or patent applications owned by Molecular Probes. [2] Hatse et al (2006). “Stromal cell-derived factor 1 (CXCL12) binds to endothelial cells and signals through a receptor different from CXCR”. Biochemical and Biophysical Research Communications 348, 192-199. [3] Strong et al (2006). “Synthetic chemokines directly labeled with a fluorescent dye as tools for studying chemokine and chemokine receptor interactions”. Eur.Cytokine Netw., 17 (1), 49-59.

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