Site-specific AF647® Labelled Chemokines

Our premium products are the AF647®[1] labelled chemokines, which are unique to Almac. The chemokines are labelled selectively at or near the C-terminus of the protein in a selective manner which ensures that only a single dye molecule is incorporated. The bright AF647® dye enables straightforward use in applications such as flow cytometry[2], and receptor recognition[3] studies.

Click on the catalogue code column of each product, to find out more, or click here to enquire.

 Chemokine Ligand Chemokine Name Receptors Catalogue code
CCL1 I-309 CCR8 CAF-7
CCL2 MCP-1 CCR2 CAF-2
CCL3 MIP-1α CCR1/CCR5 CAF-1
CCL4 h-MIP-1-beta CCR5 CAF-23
CCL5 RANTES CCR1/CCR3/CCR4/CCR5 CAF-8
CCL8 h-MCP-2 CCR1/CCR2/CCR3/CCR5 CAF-18
CCL11 Eotaxin CCR3 CAF-3
CCL15 MIP-5 CCR1/CCR3 CAF-19
CCL17 h-TARC CCR4 CAF-16
CCL18 PARC Unknown CAF-21
CCL19 MIP-3β CCR7 CAF-6
CCL20 MIP-3α CCR6 CAF-5
CCL22 MDC CCR4 CAF-4
CCL25 TECK CCR9 CAF-15
CCL28 h-MEC CCR10 CAF-20
CXCL8 IL-8 CXCR1/CXCR2 CAF-9
CXCL10 IP-10 CXCR3 CAF-10
CXCL11 ITAC CXCR3 CAF-13
CXCL12 SDF-1α CXCR4 CAF-11
CXCL12 SDF-1β CXCR4 CAF-22
CXCL13 MLC CXCR5 CAF-12
CXCL14 BRAK Unknown CAF-17
CX3CL1 Fractalktine CX3CR1 CAF-14

 

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[1] AF647®-labelled chemokines are licensed for research use under patents or patent applications owned by Molecular Probes. [2] Hatse et al (2006). “Stromal cell-derived factor 1 (CXCL12) binds to endothelial cells and signals through a receptor different from CXCR”. Biochemical and Biophysical Research Communications 348, 192-199. [3] Strong et al (2006). “Synthetic chemokines directly labeled with a fluorescent dye as tools for studying chemokine and chemokine receptor interactions”. Eur.Cytokine Netw., 17 (1), 49-59.