Immobilised CalB for Pharmaceutical Manufacturing
A proven biocatalyst for scalable, cost‑efficient and sustainable API & intermediate synthesis – enabling cleaner chemistry at commercial scale.
Immobilised CalB (Candida antarctica Lipase B) is a proven, industrial biocatalyst used at multi‑kilogram to tonne scale in pharmaceutical and intermediate manufacturing. Delivered in a stable, immobilised format, immobilised CalB enables high‑selectivity esterification and transesterification reactions under mild conditions; supporting reliable scale‑up, lower cost in use, and more sustainable processes.
In partnership with enginzyme, we support pharmaceutical manufacturers and CDMOs in evaluating, implementing, and scaling immobilised CalB‑based processes as a robust alternative to traditional chemical routes.
Why Immobilised CalB for Pharma?
Designed for real manufacturing environments, immobilised CalB is already embedded in commercial API and pharmaceutical intermediate supply chains, valued for its reliability, reusability, and supply security.
Key advantages include:
- High selectivity and consistent performance for esterification and transesterification reactions.
- Immobilised, mechanically robust format suitable for repeated batch operation.
- Reusability across multiple reaction cycles, reducing cost in use.
- Stable performance in organic solvents and mixed hydrophobic/hydrophilic systems.
- Lower operating temperatures, improving safety and energy efficiency.
- Reduced reliance on harsh reagents, supporting greener chemistry.
Proven Performance with Immobilised CalB Technology
High activity. High productivity. High confidence.
Immobilised CalB formulations have demonstrated:
These attributes make immobilised CalB particularly well‑suited to API intermediates, chiral building blocks, and functional esters used in pharmaceutical manufacturing.
Simplifying Processes, Reducing Waste
From complex chemical routes to streamlined biocatalysis
Compared to conventional chemical esterification, immobilised CalB‑enabled enzymatic processes:
This translates directly into clear ROI, reduced environmental footprint, and simpler, more robust manufacturing processes.
Built for Scale and Supply Security
Immobilised CalB solutions are suitable from laboratory evaluation through to industrial manufacture, supporting:
Multi‑kg to tonne scale supply ensures immobilised CalB can be confidently integrated into commercial manufacturing strategies.
Sustainability That Delivers Real Value
Sustainability is not an add‑on—it is embedded in immobilised CalB‑enabled processes:
How We Support You
At Almac Sciences, we go beyond enzyme supply. We support:
- Feasibility and route evaluation using immobilised CalB
- Process development and optimisation
- Scale‑up and technology transfer
- Secure, long‑term supply strategies
Our team works with process chemists, procurement, and manufacturing leaders to ensure immobilised CalB delivers measurable technical and commercial value.
