Metabolite synthesis is another tool within selectAZyme’sTM service offering that provides access to both oxidative and glycosylated products. Almac has implemented state-of-the-art biocatalytic technology for rapid metabolite synthesis, isolation and structural identification.

We have developed both recombinant and microbial P450 technology to access metabolites from mg to 100s grams scale.  These enzymes, which mimic human P450 systems, are a powerful tool for accessing difficult to synthesise metabolites rapidly.

Metabolite Synthesis

  • Cloned Human P450
  • Cloned Microbial P450
  • Extensive microbial collection

Metabolite Isolation/Structure ID

  • Analytical and prep LC
  • LC/MS
  • High-field NMR

Almac’s scale-up ability allows us to rapidly take ‘hits’ from conception to gram delivery as and when our customers require the products.

In addition, Almac can also supply radiolabelled metabolites utilising our in-house isotope chemistry group.

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