Metabolite synthesis is another tool within selectAZyme’s^TM service offering that provides access to both oxidative and glycosylated products. Almac has implemented state-of-the-art biocatalytic technology for rapid metabolite synthesis, isolation and structural identification.

We have developed both recombinant and microbial P₄₅₀ technology to access metabolites from mg to 100s grams scale.  These enzymes, which mimic human P₄₅₀ systems, are a powerful tool for accessing difficult to synthesise metabolites rapidly.

Metabolite Synthesis

• Cloned Human P₄₅₀
• Cloned Microbial P₄₅₀
• Extensive microbial collection

Metabolite Isolation/Structure ID

• Analytical and prep LC
• LC/MS
• High-field NMR

Almac’s scale-up ability allows us to rapidly take ‘hits’ from conception to gram delivery as and when our customers require the products.

In addition, Almac can also supply radiolabelled metabolites utilising our in-house isotope chemistry group.

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