Biomarker Solutions for Chronic Disease Tablet Image Biomarker Solutions for Chronic Disease Mobile Image
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Biomarker Solutions for Chronic Disease

Biomarker Solutions for Chronic Disease Tablet Image Biomarker Solutions for Chronic Disease Mobile Image
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Biomarker Solutions for Chronic Disease

 
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Chronic Disease

Chronic diseases, such as heart disease, stroke, cancer and diabetes account for approximately 74% of all deaths globally¹ and this is projected to increase by a further 17% in the next 10 years².

This rise in Chronic Disease poses major challenges for healthcare and healthcare systems in the future.

To date, the delivery of precision medicines and their associated companion and complementary diagnostics has been largely in the treatment of cancer. However, many Global Pharma and Biotech companies now recognise the need for earlier identification and treatment for a range of chronic diseases and are developing drugs and diagnostic tests, alongside partners like Almac, to treat these conditions and improve patient outcomes.

Precision Medicine & Chronic Disease

Chronic diseases, such as asthma, chronic obstructive pulmonary disease (COPD), heart failure, chronic kidney disease (CKD), metabolic dysfunction-associated steatohepatitis (MASH), inflammatory bowel disease (IBD) and brain diseases like Alzheimer’s and Parkinson’s affect billions of people worldwide.

These conditions are complex and heterogeneous, often manifesting in diverse ways, which can make accurate diagnosis & appropriate treatment challenging.

Working in tandem with Biopharma clients, Almac are trying to unravel the complex biology underlying various chronic diseases, by applying advanced technologies and robust science to help lead the way in precision medicine. Our aim is to be a key player in revolutionising the diagnosis and treatment of chronic diseases, empowering patients and healthcare providers with effective solutions.

Almac Biomarker Solutions for Chronic Disease

Almac Diagnostic Services has experience supporting biomarker strategies across multiple chronic disease indications. We help Biopharma Partners to develop precision medicine diagnostic solutions for their Biomarker programmes to help identify the right patient populations within clinical trials who should receive novel therapeutics in a targeted way. We aim to bring both drug and diagnostic test towards commercialisation and available in the market for routine clinical practice. Helping patients access new and novel treatments and helping clinicians in the identification and treatment of patients earlier in the chronic disease progression journey and there by reducing the potential future burden on healthcare budgets and systems as a result.

Almac Clinical Trial Assays – MASH / MAFLD

Almac Diagnostic Services has developed and analytically validated qPCR genotyping CTAs from blood and buccal specimen types for both PNPLA3 and HSD17B13 genes to determine molecular eligibility for MASH /MAFLD Trials.

Delivered from Almac global accredited labs (CLIA / CAP / ISO15189), they have high accuracy, sensitivity and reproducibility (100%) & are EU and US Regulation compliant for clinical trial use.

View Full MASH / MAFLD Clinical Trial Assay Specification Sheets to find out more

Find out more
Almac Clinical Trial Assays – MASH / MAFLD

We Offer

Case Studies

Download some of our current Almac Chronic Disease Case Studies.

These case studies are largely anonymised but provide a summary of some of the programmes and experience that Almac Diagnostic Services has been involved in.

Case Studies include:

* Renal
* Liver
* Respiratory
* Autoimmune
* Allergy
* IBD
* Brain
Almac Chronic Disease Case Studies

Almac Chronic Disease Case Studies

Download

Chronic Disease resources

Including press release and two panel sessions from Professor Richard Kennedy, Global VP of Biomarker Development and Medical Director at Almac Diagnostic Services.

Why Almac?

Almac offers a unique business model to biotech clients, providing complete flexibility to support the biomarker strategies required to deliver precision medicine, so that you are not tied to one solution and will always have the freedom to change.

 
A flexible business model

A flexible business model

Fee for service

Range of platform & chemistry options

Range of platform & chemistry options

qPCR, NGS, nanoString and others

Multiple disease indications

Multiple disease indications

Oncology and Chronic Diseases

Multiple sample types

Multiple sample types

Tissue, blood, saliva and a range of others

Global labs

Global labs

UK, Europe, USA and APAC

Advancing Diagnostics, No Matter The Disease

At Almac we offer a range of biomarker solutions to clients. Our precision medicine approach extends across our portfolio of services and equally applies to oncology, chronic diseases, and rare conditions.

Our commitment to chronic diseases drives us forward. Through precision medicine approaches with multiple partners, we’re helping redefine how we diagnose and treat certain chronic disease conditions. Early detection, personalised therapies, and better outcome are the goals.

NGS solutions

To see our full range of NGS solutions for DNA, RNA and Liquid Biopsy visit our platforms and technologies web section.

Almac also offer Whole Genome Sequencing, Whole Exome Sequencing and Whole Genome Methylation Sequencing for Chronic Disease programmes. Follow the links below.

qPCR and other solutions

As well as NGS solutions Almac also offer a range of qPCR and ddPCR solutions for single gene or multiple gene SNP programmes for Chronic Disease.

To future proof our approach, Almac is constantly reviewing & investing in new technology and chemistry solutions in our labs to offer not only a range of genomic solutions but also move towards epigenetics, cell & gene therapy, single cell sequencing & proteomic offerings. View a list of our current platforms and technologies

 

 


References:
  1. WHO: Non Communicable / Chronic Diseases Key Facts. Sept 2023. Available from: https://www.who.int/news-room/fact-sheets/detail/noncommunicable-diseases
  2. World Health Organization. Preventing chronic diseases: a vital investment. WHO global report. Geneva: 2005. Available from: https://www.who.int/chp/chronic_disease_report/

Partner with Almac

Learn more about Almac Diagnostic Services. Partner with us and together, we can redefine what’s possible for chronic disease management.

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