Continuous Flow Chemistry

Continuous flow manufacture is a technology platform which is gaining momentum within the pharmaceutical industry with reported FDA support for adoption into the manufacture of API’s.

Continuous Flow Chemistry opens up the possibility to access new synthetic routes to a given intermediate or API which are not achievable in conventional batch mode due to issues around safety, impurity formation and the instability of reactive intermediates.

For Almac’s partners, our continuous flow technology platform enables access to better synthetic strategies which are shorter, offer assured safety, reduce environmental impact and control of by-products. In addition, improved yields and improved reaction selectivity is achievable. With the reaction under tight control, the isolation of the product can be easier due to lowering of downstream process purification as a result of the higher quality product output. Almac aims to provide a union between batch and flow manufacture to overcome traditional batch limitations.

Flow technology is regarded as the most exciting and innovative growth technology for the preparation of API’s and we are delighted to now offer this within our portfolio as we continue to strive to provide world-class solutions to advance human health.

Continuous flow offers are a variety of advantages over traditional batch processing. There are five strategic drivers towards choosing Flow Chemistry over traditional batch as outlined below. Please click on the coloured boxes below to find out more.

Faster Reactions Safer Reactions Challenging Reactions Product Quality Smaller Footprints

Almac’s integrated flow technology platform can be applied throughout your product lifecycle to guide your synthesis project from conception to manufacture.


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